Inhibitory effects of class I and IV antiarrhythmic drugs on the Na+-activated K+ channel current in guinea pig ventricular cells

1998 ◽  
Vol 358 (6) ◽  
pp. 641-648 ◽  
Author(s):  
Katsumi Mori ◽  
Satoru Kobayashi ◽  
Toshihiro Saito ◽  
Yoshiaki Masuda ◽  
H. Nakaya
Keyword(s):  
Guinea Pig ◽  
Antiarrhythmic Drugs ◽  
Class I ◽  
K Channel ◽  
Inhibitory Effects ◽  
Channel Current ◽  
Ventricular Cells

Inhibitory effects of large Ca2+-activated K+-channel blockers on β-adrenergic- and NO-donor-mediated relaxations of human and guinea-pig airway smooth muscles

1997 ◽  
Vol 357 (1) ◽  
pp. 77-86 ◽  
Author(s):  
E. Corompt ◽  
G. Bessard ◽  
S. Lantuejoul ◽  
E. Naline ◽  
C. Advenier ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Smooth Muscles ◽  
K Channel ◽  
Channel Blockers ◽  
Inhibitory Effects ◽  
No Donor

scholarly journals Distribution of the Muscarinic K+ Channel Proteins Kir3.1 and Kir3.4 in the Ventricle, Atrium, and Sinoatrial Node of Heart

2001 ◽  
Vol 49 (10) ◽  
pp. 1221-1234 ◽  
Author(s):  
Halina Dobrzynski ◽  
David D.R. Marples ◽  
Hanny Musa ◽  
Tomoko T. Yamanushi ◽  
Zaineb Hendersonxyl ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Muscarinic Receptor ◽  
Western Blotting ◽  
K Channel ◽  
Outer Cell ◽  
Sa Node ◽  
Ventricular Cells ◽  
M2 Muscarinic Receptor ◽  
Vagal Nerves ◽  
Rat Ventricle

The functionally important effects on the heart of ACh released from vagal nerves are principally mediated by the muscarinic K+ channel. The aim of this study was to determine the abundance and cellular location of the muscarinic K+ channel subunits Kir3.1 and Kir3.4 in different regions of heart. Western blotting showed a very low abundance of Kir3.1 in rat ventricle, although Kir3.1 was undetectable in guinea pig and ferret ventricle. Although immunofluorescence on tissue sections showed no labeling of Kir3.1 in rat, guinea pig, and ferret ventricle and Kir3.4 in rat ventricle, immunofluorescence on single ventricular cells from rat showed labeling in t-tubules of both Kir3.1 and Kir3.4. Kir3.1 was abundant in the atrium of the three species, as shown by Western blotting and immunofluorescence, and Kir3.4 was abundant in the atrium of rat, as shown by immunofluorescence. Immunofluorescence showed Kir3.1 expression in SA node from the three species and Kir3.4 expression in the SA node from rat. The muscarinic K+ channel is activated by ACh via the m2 muscarinic receptor and, in atrium and SA node from ferret, Kir3.1 labeling was co-localized with m2 muscarinic receptor labeling throughout the outer cell membrane.

scholarly journals Conductance properties of the Na(+)-activated K+ channel in guinea-pig ventricular cells.

1991 ◽  
Vol 433 (1) ◽  
pp. 241-257 ◽  
Author(s):  
Z Wang ◽  
T Kimitsuki ◽  
A Noma
Keyword(s):  
Guinea Pig ◽  
K Channel ◽  
Ventricular Cells

scholarly journals Glibenclamide Specifically Blocks ATP-Sensitive K<+ Channel Current in Atrial Myocytes of Guinea Pig Heart

1990 ◽  
Vol 54 (4) ◽  
pp. 473-477 ◽  
Author(s):  
Eiji HAMADA ◽  
Reiko TAKIKAWA ◽  
Hiroyuki ITO ◽  
Mari IGUCHI ◽  
Akira TERANO ◽  
...  
Keyword(s):  
Guinea Pig ◽  
K Channel ◽  
Atrial Myocytes ◽  
Guinea Pig Heart ◽  
Channel Current
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