HIV-infection and cocaine use regulate semen extracellular vesicles proteome and miRNAome in a manner that mediates strategic monocyte haptotaxis governed by miR-128 network

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Hussein Kaddour ◽  
Steven Kopcho ◽  
Yuan Lyu ◽  
Nadia Shouman ◽  
Victor Paromov ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Extracellular Vesicles ◽  
Cocaine Use

HIV infection and cocaine use in methadone maintained and untreated intravenous drug users

1994 ◽  
Vol 36 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Borislav Meandzija ◽  
Patrick G. O'Connor ◽  
Brian Fitzgerald ◽  
Bruce J. Rounsaville ◽  
Thomas R. Kosten
Keyword(s):  
Hiv Infection ◽  
Drug Users ◽  
Intravenous Drug ◽  
Intravenous Drug Users ◽  
Cocaine Use

scholarly journals Macrophage‐derived extracellular vesicles mediate smooth muscle hyperplasia: role of altered miRNA cargo in response to HIV infection and substance abuse

2018 ◽  
Vol 32 (9) ◽  
pp. 5174-5185 ◽  
Author(s):  
Himanshu Sharma ◽  
Mahendran Chinnappan ◽  
Stuti Agarwal ◽  
Pranjali Dalvi ◽  
Sumedha Gunewardena ◽  
...  
Keyword(s):  
Substance Abuse ◽  
Smooth Muscle ◽  
Hiv Infection ◽  
Extracellular Vesicles ◽  
Muscle Hyperplasia ◽  
Smooth Muscle Hyperplasia

scholarly journals Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of amyloid precursor protein and Tau, causing neuronal dysfunction

2020 ◽  
Vol 295 (38) ◽  
pp. 13377-13392
Author(s):  
Michael Ditiatkovski ◽  
Nigora Mukhamedova ◽  
Dragana Dragoljevic ◽  
Anh Hoang ◽  
Hann Low ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Amyloid Precursor Protein ◽  
Brain Tissue ◽  
Lipid Rafts ◽  
Extracellular Vesicles ◽  
Plasma Membranes ◽  
Precursor Protein ◽  
Short Term Treatment ◽  
Hiv 1

HIV-associated neurocognitive disorders (HANDs) are a frequent outcome of HIV infection. Effective treatment of HIV infection has reduced the rate of progression and severity but not the overall prevalence of HANDs, suggesting ongoing pathological process even when viral replication is suppressed. In this study, we investigated how HIV-1 protein Nef secreted in extracellular vesicles (exNef) impairs neuronal functionality. ExNef were rapidly taken up by neural cells in vitro, reducing the abundance of ABC transporter A1 (ABCA1) and thus cholesterol efflux and increasing the abundance and modifying lipid rafts in neuronal plasma membranes. ExNef caused a redistribution of amyloid precursor protein (APP) and Tau to lipid rafts and increased the abundance of these proteins, as well as of Aβ42. ExNef further potentiated phosphorylation of Tau and activation of inflammatory pathways. These changes were accompanied by neuronal functional impairment. Disruption of lipid rafts with cyclodextrin reversed the phenotype. Short-term treatment of C57BL/6 mice with either purified recombinant Nef or exNef similarly resulted in reduced abundance of ABCA1 and elevated abundance of APP in brain tissue. The abundance of ABCA1 in brain tissue of HIV-infected human subjects diagnosed with HAND was lower, and the abundance of lipid rafts was higher compared with HIV-negative individuals. Levels of APP and Tau in brain tissue correlated with the abundance of Nef. Thus, modification of neuronal cholesterol trafficking and of lipid rafts by Nef may contribute to early stages of neurodegeneration and pathogenesis in HAND.

scholarly journals Neural sensitivity to risk in adults with co-occurring HIV infection and cocaine use disorder

2020 ◽  
Vol 20 (4) ◽  
pp. 859-872
Author(s):  
Ryan P. Bell ◽  
Sheri L. Towe ◽  
Zahra Lalee ◽  
Scott A. Huettel ◽  
Christina S. Meade
Keyword(s):  
Hiv Infection ◽  
Cocaine Use

scholarly journals HIV infection and cocaine use induce endothelial damage and dysfunction in African Americans

2012 ◽  
Vol 161 (2) ◽  
pp. 83-87 ◽  
Author(s):  
Hong Tai ◽  
Hong Lai ◽  
Jayesh Jani ◽  
Shenghan Lai ◽  
Thomas S. Kickler
Keyword(s):  
African Americans ◽  
Hiv Infection ◽  
Endothelial Damage ◽  
Cocaine Use

scholarly journals Crack cocaine use impairs anterior cingulate and prefrontal cortex function in women with HIV infection

2014 ◽  
Vol 20 (4) ◽  
pp. 352-361 ◽  
Author(s):  
Vanessa J. Meyer ◽  
Deborah M. Little ◽  
Daniel A. Fitzgerald ◽  
Erin E. Sundermann ◽  
Leah H. Rubin ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Hiv Infection ◽  
Crack Cocaine ◽  
Anterior Cingulate ◽  
Cocaine Use ◽  
Women With Hiv

scholarly journals Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Anush Arakelyan ◽  
Wendy Fitzgerald ◽  
Sonia Zicari ◽  
Christophe Vanpouille ◽  
Leonid Margolis
Keyword(s):  
Hiv Infection ◽  
Extracellular Vesicles ◽  
Lymphoid Tissue ◽  
Human Lymphoid Tissue
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