SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling

2022 ◽  
Vol 79 (1) ◽  
Author(s):  
Wenwen Zhang ◽  
Shuofei Yang ◽  
Datian Chen ◽  
Daolu Yuwen ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling ◽  
Pai 1

Abstract 2778: Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells

2014 ◽  
Author(s):  
Ling-Min Tseng ◽  
Chun-Yu Liu ◽  
Chia-Jung Hsu ◽  
Duen-Shian Wang ◽  
Jung-Chen Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling

scholarly journals 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3164
Author(s):  
Meran Keshawa Ediriweera ◽  
Jeong Yong Moon ◽  
Yen Thi-Kim Nguyen ◽  
Somi Kim Cho
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lipid Rafts ◽  
Triple Negative Breast Cancer ◽  
Lipid Raft ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling ◽  
Migration And Invasion ◽  
Membrane Raft

10-Gingerol is a major phenolic lipid found in the rhizomes of ginger (Zingiber officinale). Being amphiphilic in nature, phenolic lipids have the ability to incorporate into cell membranes and modulate membrane properties. The purpose of the present study was to evaluate the effects of 10-gingerol on lipid raft/membrane raft modulation in radio-resistant triple negative breast cancer (MDA-MB-231/IR) cells. The effects of 10-gingerol on MDA-MB-231/IR cells’ proliferation, clonogenic growth, migration, and invasion were assayed using MTT, colony formation, cell migration, and invasion assays, respectively. Sucrose density gradient centrifugation was used to extract lipid rafts. Western blotting and immunofluorescence were employed to assess the effects of 10-gingerol on lipid raft/membrane raft modulation and lipid rafts-associated PI3K/Akt signaling. Cholesterol measurements were carried out using a commercially available kit. 10-gingerol suppressed the proliferation, migration, invasion, and induced apoptosis through targeting the PI3K/Akt signaling pathway in MDA-MB-231/IR cells. Moreover, 10-gingerol was found to modulate the lipid rafts of MDA-MB-231/IR cells and attenuate the key PI3K/Akt signaling components in lipid rafts. The cholesterol content of the lipid rafts and rafts-resident Akt signaling were also affected by exposure to 10-gingerol. The results of the present study highlight rafts-associated PI3K/Akt signaling as a new target of 10-gingerol in MDA-MB-231/IR cells, thus rationalizing a new rafts-mediated treatment approach for radio-resistant triple negative breast cancer cells.

scholarly journals Correction: Lapatinib inhibits CIP2A/PP2A/p-Akt signaling and induces apoptosis in triple negative breast cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (6) ◽  
pp. 10760-10760 ◽  
Author(s):  
Chun-Yu Liu ◽  
Ming-Hung Hu ◽  
Chia-Jung Hsu ◽  
Chun-Teng Huang ◽  
Duen-Shian Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling

scholarly journals The TGFα-EGFR-Akt signaling axis plays a role in enhancing proinflammatory chemokines in triple-negative breast cancer cells

Oncotarget ◽  
2018 ◽  
Vol 9 (50) ◽  
pp. 29286-29303 ◽  
Author(s):  
Rosa Mistica C. Ignacio ◽  
Carla R. Gibbs ◽  
Eun-Sook Lee ◽  
Deok-Soo Son
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling ◽  
Signaling Axis

Abstract 1785: Neprilysin: A potential regulator of PI3K/AKT signaling in triple negative breast cancer cells

2019 ◽  
Author(s):  
Rebecca E. Conway ◽  
Katherine Iglesias ◽  
Zuhaila Hired ◽  
Grace Rutledge ◽  
Khadija Kirmani
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Akt Signaling
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