Synthesis, characterization, and evaluation of some novel 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents

2012 ◽  
Vol 22 (1) ◽  
pp. 440-452 ◽  
Author(s):  
Awatef A. Farag ◽  
Ebtsam M. Khalifa ◽  
Naima A. Sadik ◽  
Samir Y. Abbas ◽  
Abdullah G. Al-Sehemi ◽  
...  
Keyword(s):  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Quinazolinone Derivatives

scholarly journals Design and Synthesis of 7-Chloro-3-Substituted Quinazolin-4(3H)-Ones as Potential Anti-inflammatory and Analgesic Agents

2017 ◽  
Vol 9 (05) ◽  
Author(s):  
Arun Mahato ◽  
Birendra Shrivastava ◽  
Nithya Shanthi
Keyword(s):  
Spectroscopic Studies ◽  
Tail Flick ◽  
Preliminary Evaluation ◽  
Significant Activity ◽  
Design And Synthesis ◽  
Paw Oedema ◽  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Quinazolinone Derivatives

In our effort to identify potent anti-inflammatory and analgesic agents a number of 7-chloro-3-substituted-2-phenylquinazolin-4(3H)-ones have been synthesized starting from 4-chloro anthranilic acid. Docking analysis of the quinazolinone derivatives were done with COX-II protein which was carried out by means of the AutoDock program. Their structures have been elucidated on the basis of elemental analyses and spectroscopic studies (IR, 1H-NMR, MS). The synthesized compounds were tested for their analgesic activity by tail-flick method and anti-inflammatory activity by carrageenan induced rat paw oedema method. Preliminary evaluation of the anti-inflammatory and analgesic properties of the prepared compounds has indicated that some of them exhibit moderate to significant activity, compared to diclofenac standard.

Design and Synthesis of Quinazolinone Derivatives as Anti-inflammatory Agents: Pharmacophore Modeling and 3D QSAR Studies

2014 ◽  
Vol 10 (7) ◽  
pp. 711-723 ◽  
Author(s):  
P. Chaitanya ◽  
G. Reddy ◽  
G. Varun ◽  
L.M. Srikanth ◽  
V.V.S.R. Prasad ◽  
...  
Keyword(s):  
3D Qsar ◽  
Pharmacophore Modeling ◽  
Qsar Studies ◽  
Design And Synthesis ◽  
Anti Inflammatory ◽  
Quinazolinone Derivatives

Molecular Modeling, Synthesis and Pharmacological Evaluation of 1,3,4- Thiadiazoles as Anti-inflammatory and Analgesic Agents

2016 ◽  
Vol 12 (1) ◽  
pp. 90-100 ◽  
Author(s):  
Anas M. H. Shkair ◽  
Ashok K. Shakya ◽  
Nulgumnalli M. Raghavendra ◽  
Rajashri R. Naik
Keyword(s):  
Molecular Modeling ◽  
Pharmacological Evaluation ◽  
Analgesic Agents ◽  
Anti Inflammatory

scholarly journals Synthesis and Biological Evaluation of New Heteroaryl Carboxylic Acid Derivatives as Anti-inflammatory-Analgesic Agents

2013 ◽  
Vol 61 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Khaled Abouzid Mohamed Abouzid ◽  
Nadia Abdalla Khalil ◽  
Eman Mohamed Ahmed ◽  
Sawsan Abo-Bakr Zaitone
Keyword(s):  
Carboxylic Acid ◽  
Biological Evaluation ◽  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Synthesis And Biological Evaluation

scholarly journals Novel Ester and Acid Derivatives of the 1,5-Diarylpyrrole Scaffold as Anti-Inflammatory and Analgesic Agents. Synthesis and in Vitro and in Vivo Biological Evaluation

2010 ◽  
Vol 53 (2) ◽  
pp. 723-733 ◽  
Author(s):  
Mariangela Biava ◽  
Giulio C. Porretta ◽  
Giovanna Poce ◽  
Claudio Battilocchio ◽  
Fabrizio Manetti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Analgesic Agents ◽  
Anti Inflammatory ◽  
Derivatives Of
Sign in / Sign up

Export Citation Format

Share Document