Synthesis, biological evaluation, and molecular modeling studies of new 1,3,4-oxadiazole- and 1,3,4-thiadiazole-substituted 4-oxo-4H-pyrido[1,2-a]pyrimidines as anti-HIV-1 agents

Z. Hajimahdi; A. Zarghi; R. Zabihollahi; M. R. Aghasadeghi

doi:10.1007/s00044-012-0241-5

Synthesis, biological evaluation, and molecular modeling studies of new 1,3,4-oxadiazole- and 1,3,4-thiadiazole-substituted 4-oxo-4H-pyrido[1,2-a]pyrimidines as anti-HIV-1 agents

Medicinal Chemistry Research ◽

10.1007/s00044-012-0241-5 ◽

2012 ◽

Vol 22 (5) ◽

pp. 2467-2475 ◽

Cited By ~ 25

Author(s):

Z. Hajimahdi ◽

A. Zarghi ◽

R. Zabihollahi ◽

M. R. Aghasadeghi

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Anti Hiv ◽

Hiv 1

Download Full-text

Research on anti-HIV-1 agents. Part 2: Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase

Tetrahedron ◽

10.1016/s0040-4020(01)00815-8 ◽

2001 ◽

Vol 57 (39) ◽

pp. 8357-8367 ◽

Cited By ~ 26

Author(s):

Maurizio Botta ◽

Federico Corelli ◽

Giovanni Maga ◽

Fabrizio Manetti ◽

Michela Renzulli ◽

...

Keyword(s):

Molecular Modeling ◽

Reverse Transcriptase ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Biological Evaluation ◽

Phase Synthesis ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Anti Hiv ◽

Hiv 1

Download Full-text

Structural findings of quinolone carboxylic acids in cytotoxic, antiviral, and anti-HIV-1 integrase activity through validated comparative molecular modeling studies

Medicinal Chemistry Research ◽

10.1007/s00044-013-0897-5 ◽

2013 ◽

Vol 23 (6) ◽

pp. 3096-3127 ◽

Cited By ~ 14

Author(s):

Nilanjan Adhikari ◽

Amit Kumar Halder ◽

Chanchal Mondal ◽

Tarun Jha

Keyword(s):

Molecular Modeling ◽

Carboxylic Acids ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Anti Hiv ◽

Hiv 1

Download Full-text

Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: New structural insight into the HIV-1 integrase inhibition

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2011.02.028 ◽

2011 ◽

Vol 46 (5) ◽

pp. 1749-1756 ◽

Cited By ~ 17

Author(s):

Pierre Vandurm ◽

Allan Guiguen ◽

Christine Cauvin ◽

Benoît Georges ◽

Kiet Le Van ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Structural Insight ◽

Insight Into ◽

Hiv 1

Download Full-text

Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO-Like Cyclic Sulfones as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

ChemMedChem ◽

10.1002/cmdc.200500020 ◽

2006 ◽

Vol 1 (1) ◽

pp. 82-95 ◽

Cited By ~ 14

Author(s):

Roberto Di Santo ◽

Roberta Costi ◽

Marino Artico ◽

Rino Ragno ◽

Antonio Lavecchia ◽

...

Keyword(s):

Molecular Modeling ◽

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Hiv 1

Download Full-text

Research Article: Synthesis, Biological Evaluation and Molecular Modeling Studies of N-aryl-2-arylthioacetamides as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2010.01017.x ◽

2010 ◽

Vol 76 (4) ◽

pp. 330-339 ◽

Cited By ~ 7

Author(s):

Zhu Xiaohe ◽

Qin Yu ◽

Yan Hong ◽

Song Xiuqing ◽

Zhong Rugang

Keyword(s):

Molecular Modeling ◽

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Research Article ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Hiv 1

Download Full-text

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: Synthesis, biological evaluation, and molecular modeling studies

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.05.044 ◽

2013 ◽

Vol 21 (15) ◽

pp. 4575-4580 ◽

Cited By ~ 12

Author(s):

Maria Rosa Buemi ◽

Laura De Luca ◽

Alba Chimirri ◽

Stefania Ferro ◽

Rosaria Gitto ◽

...

Keyword(s):

Molecular Modeling ◽

Neurodegenerative Diseases ◽

Biological Evaluation ◽

Indole Derivatives ◽

Modeling Studies ◽

Molecular Modeling Studies

Download Full-text

Molecular modeling studies, synthesis and biological evaluation of dabigatran analogues as thrombin inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2015.11.025 ◽

2016 ◽

Vol 24 (2) ◽

pp. 73-84 ◽

Cited By ~ 8

Author(s):

Ming-Hui Dong ◽

Hai-Feng Chen ◽

Yu-Jie Ren ◽

Fang-Ming Shao

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Thrombin Inhibitors ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Synthesis And Biological Evaluation

Download Full-text

Molecular modeling studies of N-substituted pyrrole derivatives—Potential HIV-1 gp41 inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2007.12.034 ◽

2008 ◽

Vol 16 (6) ◽

pp. 3039-3048 ◽

Cited By ~ 49

Author(s):

Cátia Teixeira ◽

Florent Barbault ◽

Joseph Rebehmed ◽

Kun Liu ◽

Lan Xie ◽

...

Keyword(s):

Molecular Modeling ◽

Pyrrole Derivatives ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Hiv 1

Download Full-text

Molecular modeling studies, synthesis, and biological evaluation of Plasmodium falciparum enoyl-acyl carrier protein reductase (PfENR) inhibitors

Molecular Diversity ◽

10.1007/s11030-009-9141-0 ◽

2009 ◽

Vol 13 (4) ◽

pp. 501-517 ◽

Cited By ~ 13

Author(s):

Varun A. Morde ◽

Mushtaque S. Shaikh ◽

Raghuvir R. S. Pissurlenkar ◽

Evans C. Coutinho

Keyword(s):

Plasmodium Falciparum ◽

Molecular Modeling ◽

Acyl Carrier Protein ◽

Biological Evaluation ◽

Carrier Protein ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Synthesis And Biological Evaluation

Download Full-text

Biological Evaluation, Chelation, and Molecular Modeling Studies of Novel Metal-Chelating Inhibitors of NF-κB-DNA Binding: Structure Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm050617x ◽

2006 ◽

Vol 49 (12) ◽

pp. 3595-3601 ◽

Cited By ~ 12

Author(s):

Rakesh K. Sharma ◽

Shilpa Chopra ◽

Som D. Sharma ◽

Vineet Pande ◽

Maria J. Ramos ◽

...

Keyword(s):

Molecular Modeling ◽

Dna Binding ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Metal Chelating ◽

Structure Activity ◽

Modeling Studies ◽

Molecular Modeling Studies ◽

Binding Structure

Download Full-text