Research on anti-HIV-1 agents. Part 2: Solid-phase synthesis, biological evaluation and molecular modeling studies of 2,5,6-trisubstituted-4(3H)-pyrimidinones targeting HIV-1 reverse transcriptase

Anti Hiv ◽

Hiv 1

Synthesis, biological evaluation, and molecular modeling studies of new 1,3,4-oxadiazole- and 1,3,4-thiadiazole-substituted 4-oxo-4H-pyrido[1,2-a]pyrimidines as anti-HIV-1 agents

Medicinal Chemistry Research ◽

10.1007/s00044-012-0241-5 ◽

2012 ◽

Vol 22 (5) ◽

pp. 2467-2475 ◽

Cited By ~ 25

Author(s):

Z. Hajimahdi ◽

A. Zarghi ◽

R. Zabihollahi ◽

M. R. Aghasadeghi

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Modeling Studies ◽

Anti Hiv ◽

Hiv 1

Design, Synthesis, Biological Evaluation, and Molecular Modeling Studies of TIBO-Like Cyclic Sulfones as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

ChemMedChem ◽

10.1002/cmdc.200500020 ◽

2006 ◽

Vol 1 (1) ◽

pp. 82-95 ◽

Cited By ~ 14

Author(s):

Roberto Di Santo ◽

Roberta Costi ◽

Marino Artico ◽

Rino Ragno ◽

Antonio Lavecchia ◽

...

Keyword(s):

Molecular Modeling ◽

Reverse Transcriptase ◽

Biological Evaluation ◽

Design Synthesis ◽

Modeling Studies ◽

Hiv 1

Research Article: Synthesis, Biological Evaluation and Molecular Modeling Studies of N-aryl-2-arylthioacetamides as Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Chemical Biology & Drug Design ◽

10.1111/j.1747-0285.2010.01017.x ◽

2010 ◽

Vol 76 (4) ◽

pp. 330-339 ◽

Cited By ~ 7

Author(s):

Zhu Xiaohe ◽

Qin Yu ◽

Yan Hong ◽

Song Xiuqing ◽

Zhong Rugang

Keyword(s):

Molecular Modeling ◽

Reverse Transcriptase ◽

Biological Evaluation ◽

Research Article ◽

Modeling Studies ◽

Hiv 1

Structural findings of quinolone carboxylic acids in cytotoxic, antiviral, and anti-HIV-1 integrase activity through validated comparative molecular modeling studies

Medicinal Chemistry Research ◽

10.1007/s00044-013-0897-5 ◽

2013 ◽

Vol 23 (6) ◽

pp. 3096-3127 ◽

Cited By ~ 14

Author(s):

Nilanjan Adhikari ◽

Amit Kumar Halder ◽

Chanchal Mondal ◽

Tarun Jha

Keyword(s):

Molecular Modeling ◽

Carboxylic Acids ◽

Modeling Studies ◽

Anti Hiv ◽

Hiv 1

Solid-Phase Synthesis of the Alkenyldiarylmethane (ADAM) Series of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

The Journal of Organic Chemistry ◽

10.1021/jo0100291 ◽

2001 ◽

Vol 66 (18) ◽

pp. 5958-5964 ◽

Cited By ~ 15

Author(s):

Guozhang Xu ◽

Tracy L. Loftus ◽

Heather Wargo ◽

Jim A. Turpin ◽

Robert W. Buckheit, ◽

...

Keyword(s):

Reverse Transcriptase ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Phase Synthesis ◽

Hiv 1

Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2013.08.040 ◽

2013 ◽

Vol 21 (21) ◽

pp. 6477-6483 ◽

Cited By ~ 4

Author(s):

Hai-Qiu Wu ◽

Zi-Hong Yan ◽

Wen-Xue Chen ◽

Qiu-Qin He ◽

Fen-Er Chen ◽

...

Keyword(s):

Molecular Modeling ◽

Reverse Transcriptase ◽

Biological Investigation ◽

Modeling Studies ◽

Hiv 1

Synthesis, biological evaluation and molecular modeling studies of quinolonyl diketo acid derivatives: New structural insight into the HIV-1 integrase inhibition

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2011.02.028 ◽

2011 ◽

Vol 46 (5) ◽

pp. 1749-1756 ◽

Cited By ~ 17

Author(s):

Pierre Vandurm ◽

Allan Guiguen ◽

Christine Cauvin ◽

Benoît Georges ◽

Kiet Le Van ◽

...

Keyword(s):

Molecular Modeling ◽

Biological Evaluation ◽

Modeling Studies ◽

Structural Insight ◽

Insight Into ◽

Hiv 1

Diversity-oriented solid-phase synthesis and biological evaluation of oligonucleotide hairpins as HIV-1 RT RNase H inhibitors

Nucleic Acids Research ◽

10.1093/nar/gkh948 ◽

2004 ◽

Vol 32 (21) ◽

pp. 6164-6175 ◽

Cited By ~ 7

Author(s):

Rami N. Hannoush ◽

Kyung-Lyum Min ◽

Masad J. Damha

Keyword(s):

Solid Phase Synthesis ◽

Solid Phase ◽

Biological Evaluation ◽

Rnase H ◽

Phase Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

Solid-phase synthesis of 5′-O-β,γ-methylenetriphosphate derivatives of nucleosides and evaluation of their inhibitory activity against HIV-1 reverse transcriptase

Tetrahedron Letters ◽

10.1016/j.tetlet.2010.04.005 ◽

2010 ◽

Vol 51 (22) ◽

pp. 3010-3013 ◽

Cited By ~ 9

Author(s):

Yousef Ahmadibeni ◽

Chandravanu Dash ◽

Stuart F.J. Le Grice ◽

Keykavous Parang

Keyword(s):

Reverse Transcriptase ◽

Inhibitory Activity ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Phase Synthesis ◽

Derivatives Of ◽

Hiv 1

Design, Synthesis, SAR, and Molecular Modeling Studies of Acylthiocarbamates: A Novel Series of Potent Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors Structurally Related to Phenethylthiazolylthiourea Derivatives

Journal of Medicinal Chemistry ◽

10.1021/jm0209984 ◽

2003 ◽

Vol 46 (5) ◽

pp. 768-781 ◽

Cited By ~ 23

Author(s):

Angelo Ranise ◽

Andrea Spallarossa ◽

Silvia Schenone ◽

Olga Bruno ◽

Francesco Bondavalli ◽

...

Keyword(s):

Molecular Modeling ◽

Reverse Transcriptase ◽

Design Synthesis ◽

Modeling Studies ◽

Hiv 1