Regulation of endothelial progenitor cell functions during hyperglycemia: new therapeutic targets in diabetic wound healing

2022 ◽  
Author(s):  
Gui Wan ◽  
Yangyang Chen ◽  
Jing Chen ◽  
Chengqi Yan ◽  
Cheng Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Therapeutic Targets ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Cell Functions ◽  
Diabetic Wound Healing ◽  
New Therapeutic Targets

535-P: Neurotensin Improves Endothelial Progenitor Cell Function in Diabetic Wound Healing

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 535-P
Author(s):  
ERMELINDO C. LEAL ◽  
ANA FIGUEIREDO ◽  
EUGENIA CARVALHO
Keyword(s):  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Cell Function ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Diabetic Wound Healing

scholarly journals Platelet-Rich Plasma with Endothelial Progenitor Cells Accelerates Diabetic Wound Healing in Rats by Upregulating the Notch1 Signaling Pathway

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Cheng Zhang ◽  
Yu Zhu ◽  
Shengdi Lu ◽  
Wanrun Zhong ◽  
Yanmao Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Signaling Pathway ◽  
Platelet Rich Plasma ◽  
Diabetic Wound ◽  
Endothelial Progenitor ◽  
Notch1 Signaling ◽  
Diabetic Wound Healing ◽  
Notch1 Signaling Pathway ◽  
Diabetic Wounds

Diabetic wounds, as a kind of refractory wound, are very difficult to heal. Both endothelial progenitor cell (EPC) transplantation and platelet-rich plasma (PRP) can improve diabetic wound healing to some extent. However, PRP application cannot provide reparative cells, while EPC transplantation cannot replenish the required growth factors for wound healing. Thus, when applied alone, neither of these factors is sufficient for effective wound healing. Furthermore, the proliferation, differentiation, and fate of the transplanted EPCs are not well known. Therefore, in this study, we examined the efficacy of combined PRP application with EPC transplantation in diabetic wound healing. Our results indicated that PRP application improved EPC proliferation and migration. The Notch signaling pathway plays a key role in the regulation of the proliferation and differentiation of stem cells and angiogenesis in wound healing. The application of PRP upregulated the Notch pathway-related gene and protein expression in EPCs. Furthermore, experiments with shNotch1-transfected EPCs indicated that PRP enhanced the function of EPCs by upregulating the Notch1 signaling pathway. In vivo studies further indicated that the combination of PRP and EPC transplantation increased neovascularization, reduced wound size, and improved healing in rat wound models. Thus, PRP application can provide the necessary growth factors for wound healing, while EPC transplantation offers the required cells, indicating that the combination of both is a potent novel approach for treating diabetic wounds.

scholarly journals The bone marrow-derived endothelial progenitor cell response is impaired in delayed wound healing from ischemia

2006 ◽  
Vol 43 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Stephen M. Bauer ◽  
Lee J. Goldstein ◽  
Richard J. Bauer ◽  
Haiying Chen ◽  
Mary Putt ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Endothelial Progenitor Cell ◽  
Cell Response ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Delayed Wound Healing

scholarly journals Phosphoinositide 3-Kinase γ Gene Knockout Impairs Postischemic Neovascularization and Endothelial Progenitor Cell Functions

2008 ◽  
Vol 28 (1) ◽  
pp. 68-76 ◽  
Author(s):  
Paolo Madeddu ◽  
Nicolle Kraenkel ◽  
Luciola S. Barcelos ◽  
Mauro Siragusa ◽  
Paola Campagnolo ◽  
...  
Keyword(s):  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Gene Knockout ◽  
Endothelial Progenitor ◽  
Cell Functions ◽  
Phosphoinositide 3 Kinase
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