Changing trends in the use of cartilage restoration techniques for the patellofemoral joint: a systematic review

2018 ◽  
Vol 27 (3) ◽  
pp. 854-867 ◽  
Author(s):  
Ajaykumar Shanmugaraj ◽  
Ryan P. Coughlin ◽  
Gabriel N. Kuper ◽  
Seper Ekhtiari ◽  
Nicole Simunovic ◽  
...  
Cartilage ◽  
2019 ◽  
pp. 194760351989307 ◽  
Author(s):  
Renato Andrade ◽  
Joni Nunes ◽  
Betina B. Hinckel ◽  
Jordan Gruskay ◽  
Sebastiano Vasta ◽  
...  

Purpose This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery. Methods This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). PubMed, EMBASE, and Cochrane Library databases were searched up to August 31, 2018, to identify clinical studies that assessed surgical outcomes of patellofemoral cartilage restoration surgery. The Methodological Index for Non-Randomized Studies (MINORS) was used to assess study quality. Results Forty-two studies were included comprising 1,311 knees (mean age of 33.7 years and 56% males) and 1,309 patellofemoral defects (891 patella, 254 trochlear, 95 bipolar, and 69 multiple defects, including the patella or trochlea) at a mean follow-up of 59.2 months. Restoration techniques included autologous chondrocyte implantation (56%), particulated juvenile allograft cartilage (12%), autologous matrix-induced chondrogenesis (9%), osteochondral autologous transplantation (9%), and osteochondral allograft transplantation (7%). Significant improvement in at least one score was present in almost all studies and these surpassed the minimal clinically important difference threshold. There was a weighted 19%, 35%, and 6% rate of reported complications, reoperations, and failures, respectively. Concomitant patellofemoral surgery (51% of patients) mostly did not lead to statistically different postoperative outcomes. Conclusion Numerous patellofemoral restoration techniques result in significant functional improvement with a low rate of failure. No definitive conclusions could be made to determine the best surgical technique since comparative studies on this topic are rare, and treatment choice should be made according to specific patient and defect characteristics. Level of evidence Level IV, systematic review of level II to IV studies.


Author(s):  
Anirudh K. Gowd ◽  
Alexander E. Weimer ◽  
Danielle E. Rider ◽  
Edward C. Beck ◽  
Avinesh Agarwalla ◽  
...  

2017 ◽  
Vol 25 (5) ◽  
pp. 321-329 ◽  
Author(s):  
Robert H. Brophy ◽  
Robert D. Wojahn ◽  
Joseph D. Lamplot

Author(s):  
Anirudh K. Gowd ◽  
Alexander E. Weimer ◽  
Danielle E. Rider ◽  
Edward C. Beck ◽  
Avinesh Agarwalla ◽  
...  

Author(s):  
Nicolas Brown ◽  
Geoffrey S. Van Thiel ◽  
Brian J. Cole

2014 ◽  
Vol 48 (3) ◽  
pp. 132-138
Author(s):  
Sunil Dogra ◽  
Samir Malhotra ◽  
Promila Pandhi ◽  
Sharonjeet Kaur ◽  
Sujit Rajagopalan ◽  
...  

ABSTRACT Background Toxic epidermal necrolysis (TEN) is a rare idiosyncratic mucocutaneous reaction associated with high mortality. Drugs are most commonly implicated in TEN. The treatment constitutes stopping the offending drug, along with symptomatic management. In this study, we searched for case reports/series of TEN and analyzed data to find the most commonly implicated drugs in TEN, effects of use of corticosteroids on mortality in TEN patients, changing trends in mortality over the past 3 decades and difference in mortality rates in both developing and developed countries. Materials and methods We searched for case reports/series of TEN to evaluate most commonly implicated drugs in TEN, effects of use of corticosteroids on mortality in TEN patients, changing trends in mortality over the past three decades and difference in mortality rates in both developing and developed countries. Results Antibiotics (28.6%) followed by antiepileptics (17.4%) and nonsteroidal anti-inflammatory drugs (9.6%) are most commonly implicated. There was nonsignificant decrease in mortality among steroids users as compared to nonusers (OR = 2.0, CI 0.96-4.24). During the period between 1980 and 1989 the reported mortality in TEN cases was approximately 33.4%, which decreased to 27% in the next two decades. There was a nonsignificant difference in mortality in develo- ping countries as compared to developed countries (OR: 0.70, CI 0.32-1.53). Conclusion Corticosteroids have been associated with non significant reduction in the mortality. Apart from this, mortality did not differ over years together in both developing and developed countries. How to cite this article Kaur S, Rajagopalan S, Shafiq N, Dogra S, Srinivasan A, Pandhi P, Malhotra S. Drugs Implicated, Mortality and Use of Corticosteroids in Toxic Epidermal Necrolysis Cases: A Systematic Review of Published Case Reports and Case Series. J Postgrad Med Edu Res 2014;48(3):132-138.


Author(s):  
Jack Farr ◽  
Brian J. Cole ◽  
Michael J. Salata ◽  
Marco Collarile ◽  
Sarvottam Bajaj

2017 ◽  
Vol 33 (2) ◽  
pp. 486-492 ◽  
Author(s):  
Cynthia A. Kahlenberg ◽  
Benedict U. Nwachukwu ◽  
Kamran S. Hamid ◽  
Michael E. Steinhaus ◽  
Riley J. Williams

2020 ◽  
Vol 14 (01) ◽  
pp. 128-143 ◽  
Author(s):  
Anas Imran Arshad ◽  
Paras Ahmad ◽  
Paul M.H. Dummer ◽  
Mohammad Khursheed Alam ◽  
Jawaad Ahmed Asif ◽  
...  

Abstract Objective A systematic search was performed for the identification and analysis of the 100 most often cited articles on dental caries and to highlight the changing trends in the field of dentistry over time. Materials and Methods The search was performed without any restriction on the study design, publication year, or language using the Web of Science (WoS) group of Clarivate Analytics enabling the search through “All Databases.” Based on the citation count as available in WoS, the articles were sorted in a descending manner. Information regarding each article was then extracted, which included its authorship, counts of citation (in other databases), citation density, current citation index (2019), publication year, country of publication, journal of article, evidence level based on study design, and keywords description. Results The count of citation for each article varied in each database, that is, 175 to 2,003 in WoS, 89 to 1,981 in Scopus, and 126 to 3,492 when searched in Google Scholar. The highest number of articles (n = 10) related to dental caries were published in 2004. A total of 301 authors made valuable contributions to this field, out of which J.D. Featherstone had coauthored 6 articles. A significant negative correlation (p < 0.01) was found between the age of the article and the citation density (r =–0.545). However, a nonsignificant correlation (p = 0.952) occurred between the age of publication and the citation count (r = 0.006). Conclusion The results of this systematic review provide a critical appraisal of the context underpinning scientific developments in the field of dental caries and also highlighted trends in clinical management and research.


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