Association of unipedal standing time and bone mineral density in community-dwelling Japanese women

2008 ◽  
Vol 20 (5) ◽  
pp. 731-736 ◽  
Author(s):  
A. Sakai ◽  
N. Toba ◽  
M. Takeda ◽  
M. Suzuki ◽  
Y. Abe ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Japanese Women ◽  
Community Dwelling ◽  
Mineral Density ◽  
Standing Time ◽  
Unipedal Standing

scholarly journals Association of Polymorphisms of Interleukin-6, Osteocalcin, and Vitamin D Receptor Genes, Alone or in Combination, with Bone Mineral Density in Community-Dwelling Japanese Women and Men

2003 ◽  
Vol 88 (7) ◽  
pp. 3372-3378 ◽  
Author(s):  
Yoshiji Yamada ◽  
Fujiko Ando ◽  
Naoakira Niino ◽  
Hiroshi Shimokata
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Japanese Women ◽  
Community Dwelling ◽  
Mineral Density ◽  
Vdr Gene ◽  
Osteocalcin Gene

We examined whether the −634C→G, 298C→T, and 2C→T polymorphisms of the IL-6, osteocalcin, and vitamin D receptor (VDR) genes, respectively, were associated, alone or in combination, with bone mineral density (BMD) in community-dwelling Japanese women (between 1108 and 1113) or men (between 1116 and 1130) aged 40–79 yr. The −634C→G polymorphism of the IL-6 gene and the 298C→T polymorphism of the osteocalcin gene were associated with BMD in postmenopausal women, with the respective GG and TT genotypes representing risk factors for reduced bone mass. IL-6 and osteocalcin genotypes showed additive effects on BMD for postmenopausal women. The 2C→T polymorphism of the VDR gene was associated with BMD in men, with the CT genotype contributing to reduced BMD. These results suggest that the IL-6 and osteocalcin genes are susceptibility loci for reduced BMD in postmenopausal women and that the VDR gene constitutes such a locus in men. The combined IL-6 and osteocalcin genotypes may prove informative for the assessment of osteoporosis in women.

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