Anhydroecgonine methyl ester, a cocaine pyrolysis product, contributes to cocaine-induced rat primary hippocampal neuronal death in a synergistic and time-dependent manner

2021 ◽  
Author(s):  
Mariana Sayuri Berto Udo ◽  
Mariana Aguilera Alencar da Silva ◽  
Sara de Souza Prates ◽  
Leandro Ferreira Dal’Jovem ◽  
Stephanie de Oliveira Duro ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Neuronal Death ◽  
Pyrolysis Product ◽  
Time Dependent ◽  
Dependent Manner ◽  
Anhydroecgonine Methyl Ester

scholarly journals Neurotoxicity of Anhydroecgonine Methyl Ester, a Crack Cocaine Pyrolysis Product

2012 ◽  
Vol 128 (1) ◽  
pp. 223-234 ◽  
Author(s):  
R. C. T. Garcia ◽  
L. M. M. Dati ◽  
S. Fukuda ◽  
L. H. L. Torres ◽  
S. Moura ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Crack Cocaine ◽  
Pyrolysis Product ◽  
Anhydroecgonine Methyl Ester

Gelatinase B and TIMP-1 are regulated in a cell- and time-dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia

2002 ◽  
Vol 15 (1) ◽  
pp. 19-32 ◽  
Author(s):  
Santiago Rivera ◽  
Crystel Ogier ◽  
Jérôme Jourquin ◽  
Serge Timsit ◽  
Arkadius W. Szklarczyk ◽  
...  
Keyword(s):  
Neuronal Death ◽  
Time Dependent ◽  
Dependent Manner ◽  
Forebrain Ischemia ◽  
Gelatinase B ◽  
A Cell ◽  
Glial Reactivity

Anhydroecgonine methyl ester, a cocaine pyrolysis product, may contribute to cocaine behavioral sensitization

Toxicology ◽  
2017 ◽  
Vol 376 ◽  
pp. 44-50 ◽  
Author(s):  
Raphael Caio Tamborelli Garcia ◽  
Larissa Helena Torres ◽  
Natália Trigo Balestrin ◽  
Tatiana Costa Andrioli ◽  
Jorge Camilo Flório ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Behavioral Sensitization ◽  
Pyrolysis Product ◽  
Anhydroecgonine Methyl Ester

scholarly journals Anhydroecgonine methyl ester (AEME), a cocaine pyrolysis product, impairs glutathione-related enzymes response and increases lipid peroxidation in the hippocampal cell culture

2019 ◽  
Vol 6 ◽  
pp. 1223-1229 ◽  
Author(s):  
Raphael Caio Tamborelli Garcia ◽  
Larissa Lobo Torres ◽  
Livia Mendonça Munhoz Dati ◽  
Ana Paula de Melo Loureiro ◽  
Solange Castro Afeche ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Cell Culture ◽  
Methyl Ester ◽  
Pyrolysis Product ◽  
Hippocampal Cell ◽  
Hippocampal Cell Culture ◽  
Anhydroecgonine Methyl Ester

scholarly journals M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Raphael Caio Tamborelli Garcia ◽  
Livia Mendonça Munhoz Dati ◽  
Larissa Helena Torres ◽  
Mariana Aguilera Alencar da Silva ◽  
Mariana Sayuri Berto Udo ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Muscarinic Receptors ◽  
Pyrolysis Product ◽  
Anhydroecgonine Methyl Ester

scholarly journals The muscarinic effect of anhydroecgonine methyl ester, a crack cocaine pyrolysis product, impairs melatonin synthesis in the rat pineal gland

2017 ◽  
Vol 6 (4) ◽  
pp. 420-431 ◽  
Author(s):  
Lívia Silva Medeiros de Mesquita ◽  
Raphael Caio Tamborelli Garcia ◽  
Fernanda Gaspar Amaral ◽  
Rafael Peres ◽  
Simone Miller Wood ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Pineal Gland ◽  
Muscarinic Receptors ◽  
Crack Cocaine ◽  
Pyrolysis Product ◽  
Melatonin Synthesis ◽  
Rat Pineal Gland ◽  
Anhydroecgonine Methyl Ester

AEME impaired melatonin synthesis bothin vivoand in vitro and this effect seems to be mediated by muscarinic receptors and [Ca2+]i elevation.

Testing Human Hair and Urine for Anhydroecgonine Methyl Ester, a Pyrolysis Product of Cocaine

1995 ◽  
Vol 19 (6) ◽  
pp. 479-482 ◽  
Author(s):  
P. Kintz ◽  
V. Cirimele ◽  
C. Sengler ◽  
P. Mangin
Keyword(s):  
Methyl Ester ◽  
Human Hair ◽  
Pyrolysis Product ◽  
Anhydroecgonine Methyl Ester

A Pyrolysis Product, Anhydroecgonine Methyl Ester (Methylecgonidine), is in the Urine of Cocaine Smokers

1990 ◽  
Vol 14 (6) ◽  
pp. 353-357 ◽  
Author(s):  
Peyton Jacob ◽  
Evan R. Lewis ◽  
Barbara A. Elias-Baker ◽  
Reese T. Jones
Keyword(s):  
Methyl Ester ◽  
Pyrolysis Product ◽  
Anhydroecgonine Methyl Ester
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