Effect of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on growth factor expression in the human breast cancer cell line MCF-7

1995 ◽  
Vol 69 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Christoph Vogel ◽  
Josef Abel
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Factor Expression ◽  
Growth Factor Expression ◽  
Mcf 7

Constitutive tissue factor expression of human breast cancer cell line MCF-7 is modulated by growth factors

1992 ◽  
Vol 28 (12) ◽  
pp. 1999-2002 ◽  
Author(s):  
Conrad Flössel ◽  
Thomas Luther ◽  
Sybille Albrecht ◽  
Matthias Kotzsch ◽  
Martin Müller
Keyword(s):  
Breast Cancer ◽  
Growth Factors ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Tissue Factor Expression ◽  
Human Breast ◽  
Factor Expression ◽  
Mcf 7

scholarly journals Connective Tissue Growth Factor Induces Apoptosis in Human Breast Cancer Cell Line MCF-7

1999 ◽  
Vol 274 (52) ◽  
pp. 37461-37466 ◽  
Author(s):  
Keiichi Hishikawa ◽  
Barry S. Oemar ◽  
Felix C. Tanner ◽  
Toshio Nakaki ◽  
Thomas F. Lüscher ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Connective Tissue ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Tissue Growth ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Mcf 7

Design, Synthesis and In Vitro Evaluation of 18β-Glycyrrhetinic Acid Derivatives for Anticancer Activity Against Human Breast Cancer Cell Line MCF-7

2014 ◽  
Vol 21 (9) ◽  
pp. 1160-1170 ◽  
Author(s):  
Dharmendra Yadav ◽  
Komal Kalani ◽  
Abhishek Singh ◽  
Feroz Khan ◽  
Santosh Srivastava ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Design Synthesis ◽  
Mcf 7

Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7

1988 ◽  
Vol 118 (1) ◽  
pp. 149-154 ◽  
Author(s):  
E. F. Adams ◽  
N. G. Coldham ◽  
V. H. T. James
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Breast Cancer ◽  
Transforming Growth Factor ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Epidermal Growth ◽  
Mcf 7

ABSTRACT We have examined the direct effects of progestins, oestrogens, peptide hormones and growth factors on oestradiol-17β dehydrogenase (OE2DH) activity of cultures of the human breast cancer cell line MCF-7. Cells were cultured in the presence of steroid or peptide for 6 days, after which the number of cells was determined and cellular OE2DH activity assessed. Progesterone, 6α-methyl-17α-hydroxyprogesterone acetate, norethisterone and d(−)-norgestrel all profoundly inhibited cell mitosis and stimulated reductive (oestrone→oestradiol-17β) and oxidative (oestradiol-17β→oestrone) OE2DH activity. Both oestrone and oestradiol-17β directly stimulated reductive OE2DH activity, but had no effect on the oxidative direction. Oestradiol-17β stimulated cell growth only in phenolred free culture medium. Ovine prolactin, LH, epidermal growth factor and transforming growth factor did not alter OE2DH activity but small stimulatory effects on the growth of MCF-7 cells were exerted by prolactin and a combination of transforming growth factor with epidermal growth factor. It is concluded that these results may explain, at least in part, the alterations in mitotic activity and tissue oestradiol-17β levels observed in breast tissue during varying physiological and pathological conditions, such as during the menstrual cycle and in breast cancers. J. Endocr. (1988) 118, 149–154

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