The growth inhibitory effect of gambogic acid on pancreatic cancer cells

2018 ◽  
Vol 391 (5) ◽  
pp. 551-560 ◽  
Author(s):  
Mаhmoud Youns ◽  
Abeer ElKhoely ◽  
Rehab Kamel
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Gambogic Acid ◽  
Growth Inhibitory Effect ◽  
Pancreatic Cancer Cells ◽  
Growth Inhibitory

Agonistic anti-Fas antibody has the growth inhibitory effect on pancreatic cancer cells independent of DcR3

2001 ◽  
Vol 120 (5) ◽  
pp. A341
Author(s):  
Shoichiro Tsuji ◽  
Toshihiko Masui ◽  
Jun Ida ◽  
Sanae Nakajima ◽  
Michiya Kawaguchi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Pancreatic Cancer Cells ◽  
Growth Inhibitory

Agonistic anti-Fas antibody has the growth inhibitory effect on pancreatic cancer cells independent of DcR3

2001 ◽  
Vol 120 (5) ◽  
pp. A341-A341
Author(s):  
S TSUJI ◽  
T MASUI ◽  
J IDA ◽  
S NAKAJIMA ◽  
M KAWAGUCHI ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Pancreatic Cancer Cells ◽  
Growth Inhibitory

scholarly journals Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells

2021 ◽  
Vol 20 ◽  
pp. 153473542110061
Author(s):  
Hyun-Jin Jang ◽  
Jae Ho Yang ◽  
Eunmi Hong ◽  
Eunbi Jo ◽  
Soon Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Annexin V ◽  
Inhibitory Effect ◽  
Human Pancreatic Cancer ◽  
Mrna Levels ◽  
Chelidonium Majus ◽  
Pancreatic Cancer Cells ◽  
Growth Inhibitory ◽  
Anti Cancer

Chelidonium majus has been used as a traditional medicine in China and western countries for various diseases, including inflammation and cancer. However, the anti-cancer effect of chelidonine, a major compound of C. majus extracts, on pancreatic cancer remains poorly understood. In this study, we found that treatment with chelidonine inhibited proliferation of BxPC-3 and MIA PaCa-2 human pancreatic cancer cells. Annexin-V/propidium iodide staining assay showed that this growth inhibitory effect of chelidonine was induced through apoptosis. We found that chelidonine treatment upregulated mRNA levels and transcription factor activity in both cell lines. Increases in protein expression levels of p53, GADD45A, p21 and cleaved caspase-3 were also observed, with more distinct changes in MIA PaCa-2 cells compared to the BxPC-3 cells. These results suggest that chelidonine induces pancreatic cancer apoptosis through the p53 and GADD45A pathways. Our findings provide new insights into the use of chelidonine for the treatment of pancreatic cancer.

scholarly journals Low glucose enhanced metformin’s inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p

Cell Cycle ◽  
2020 ◽  
Vol 19 (17) ◽  
pp. 2168-2181
Author(s):  
Minglei Ma ◽  
Chifa Ma ◽  
Pingping Li ◽  
Chunxiao Ma ◽  
Fan Ping ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Pancreatic Cancer Cells ◽  
Energy Stress ◽  
Low Glucose

S2015 Growth Inhibitory Effects of Polyphenols in Scutellaria Baicalensis in Pancreatic Cancer Cells

2009 ◽  
Vol 136 (5) ◽  
pp. A-313 ◽  
Author(s):  
Monica C. Chen ◽  
Diane M. Harris ◽  
Qing Y. Lu ◽  
Eliane Angst ◽  
Jenny L. Park ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Scutellaria Baicalensis ◽  
Inhibitory Effects ◽  
Pancreatic Cancer Cells ◽  
Growth Inhibitory
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