Analgesic effects of mirogabalin, a novel ligand for α2δ subunit of voltage-gated calcium channels, in experimental animal models of fibromyalgia

2019 ◽  
Vol 392 (6) ◽  
pp. 723-728 ◽  
Author(s):  
Kensuke Saeki ◽  
Shun-ichi Yasuda ◽  
Masami Kato ◽  
Mayumi Kano ◽  
Yuki Domon ◽  
...  
Keyword(s):  
Animal Models ◽  
Calcium Channels ◽  
Experimental Animal ◽  
Experimental Animal Models ◽  
Voltage Gated ◽  
Analgesic Effects ◽  
Voltage Gated Calcium Channels ◽  
Α2δ Subunit

N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the α2δ subunit of voltage gated calcium channels

2004 ◽  
Vol 14 (8) ◽  
pp. 1913-1916 ◽  
Author(s):  
Jongwon Lim ◽  
Nicholas Stock ◽  
Richard Pracitto ◽  
Julia K Boueres ◽  
Benito Munoz ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Affinity Ligands ◽  
Voltage Gated ◽  
High Affinity ◽  
Voltage Gated Calcium Channels ◽  
Α2δ Subunit

Anti-inflammatory and analgesic effects of Careya arborea stem bark in experimental animal models

2006 ◽  
Vol 9 (1) ◽  
Author(s):  
R Sambathkumar ◽  
T Sivakumar ◽  
R Shanmuga Sundaram ◽  
P Sivakumar ◽  
R Nethaji ◽  
...  
Keyword(s):  
Animal Models ◽  
Experimental Animal ◽  
Stem Bark ◽  
Experimental Animal Models ◽  
Analgesic Effects ◽  
Anti Inflammatory

scholarly journals Animal models to evaluate analgesic effects using isobolographic analysis

2012 ◽  
Vol 1 (1) ◽  
Author(s):  
María Asunción Romero Molina
Keyword(s):  
Clinical Practice ◽  
Animal Models ◽  
Experimental Animal ◽  
Severe Pain ◽  
Preclinical Study ◽  
Isobolographic Analysis ◽  
Experimental Animal Models ◽  
Analgesic Effects ◽  
Single Drug ◽  
Accurate Design

In the daily clinical practice, combined pharmacotherapy is often used when a single drug (monotherapy) treatment is not enough to relief moderate-severe pain in patients. The use of experimental animal models offers us great tools for the translation of data from animals to human. However, the accurate design of the preclinical study is a requisite to obtain valid outcomes. Using the isobolographic analysis we can easily establish differences between synergistic or additive responses expected from drug combinations, improving the management and treatment of pain.

Structure–activity relationships of α-amino acid ligands for the α2δ subunit of voltage-gated calcium channels

2006 ◽  
Vol 16 (5) ◽  
pp. 1138-1141 ◽  
Author(s):  
Kathleen H. Mortell ◽  
David J. Anderson ◽  
James J. Lynch ◽  
Sherry L. Nelson ◽  
Kathy Sarris ◽  
...  
Keyword(s):  
Amino Acid ◽  
Calcium Channels ◽  
Voltage Gated ◽  
Structure Activity Relationships ◽  
Voltage Gated Calcium Channels ◽  
Structure Activity ◽  
Α2δ Subunit
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