Tag-femtosecond laser-induced breakdown spectroscopy for the sensitive detection of cancer antigen 125 in blood plasma

2015 ◽  
Vol 407 (7) ◽  
pp. 1849-1855 ◽  
Author(s):  
Yuri Markushin ◽  
Poopalasingam Sivakumar ◽  
Denise Connolly ◽  
Noureddine Melikechi
Keyword(s):  
Femtosecond Laser ◽  
Blood Plasma ◽  
Sensitive Detection ◽  
Laser Induced Breakdown Spectroscopy ◽  
Cancer Antigen 125 ◽  
Cancer Antigen ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
In Blood Plasma

Nanosecond laser-induced breakdown assisted by femtosecond laser pre-ionization in air: the effect on spatial resolution and continuous radiation

2020 ◽  
Vol 92 (2) ◽  
pp. 20701
Author(s):  
Bo Li ◽  
Xiaofeng Li ◽  
Zhifeng Zhu ◽  
Qiang Gao
Keyword(s):  
Femtosecond Laser ◽  
Spatial Resolution ◽  
Laser Induced Breakdown Spectroscopy ◽  
Nanosecond Laser ◽  
Breakdown Threshold ◽  
Powerful Technique ◽  
Breakdown Spectroscopy ◽  
Continuous Radiation ◽  
Laser Induced Breakdown

Laser-induced breakdown spectroscopy (LIBS) is a powerful technique for quantitative diagnostics of gases. The spatial resolution of LIBS, however, is limited by the volume of plasma. Here femtosecond-nanosecond dual-pulsed LIBS was demonstrated. Using this method, the breakdown threshold was reduced by 80%, and decay of continuous radiation was shortened. In addition, the volume of the plasma was shrunk by 85% and hence, the spatial resolution of LIBS was significantly improved.

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