High spatial resolution imaging of melanoma tissue by femtosecond laser-induced breakdown spectroscopy

2021 ◽  
Vol 179 ◽  
pp. 106090
Author(s):  
Jang-Hee Choi ◽  
Sungho Shin ◽  
Youngmin Moon ◽  
Jung Hyun Han ◽  
Euiseok Hwang ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown ◽  
Resolution Imaging ◽  
High Spatial Resolution Imaging ◽  
Melanoma Tissue

Nanosecond laser-induced breakdown assisted by femtosecond laser pre-ionization in air: the effect on spatial resolution and continuous radiation

2020 ◽  
Vol 92 (2) ◽  
pp. 20701
Author(s):  
Bo Li ◽  
Xiaofeng Li ◽  
Zhifeng Zhu ◽  
Qiang Gao
Keyword(s):  
Femtosecond Laser ◽  
Spatial Resolution ◽  
Laser Induced Breakdown Spectroscopy ◽  
Nanosecond Laser ◽  
Breakdown Threshold ◽  
Powerful Technique ◽  
Breakdown Spectroscopy ◽  
Continuous Radiation ◽  
Laser Induced Breakdown

Laser-induced breakdown spectroscopy (LIBS) is a powerful technique for quantitative diagnostics of gases. The spatial resolution of LIBS, however, is limited by the volume of plasma. Here femtosecond-nanosecond dual-pulsed LIBS was demonstrated. Using this method, the breakdown threshold was reduced by 80%, and decay of continuous radiation was shortened. In addition, the volume of the plasma was shrunk by 85% and hence, the spatial resolution of LIBS was significantly improved.

scholarly journals Femtosecond Single-Pulse and Orthogonal Double-Pulse Laser-Induced Breakdown Spectroscopy (LIBS): Femtogram Mass Detection and Chemical Imaging with Micrometer Spatial Resolution

2021 ◽  
pp. 000370282110423
Author(s):  
Nikolaos Giannakaris ◽  
Anna Haider ◽  
Christoph M. Ahamer ◽  
Stefan Grünberger ◽  
Stefan Trautner ◽  
...  
Keyword(s):  
Laser Pulse ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Single Pulse ◽  
High Energy ◽  
Chemical Imaging ◽  
Double Pulse ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown

Femtosecond laser-induced breakdown spectroscopy (fs-LIBS) is employed to detect tiny amounts of mass ablated from macroscopic specimens and to measure chemical images of microstructured samples with high spatial resolution. Frequency-doubled fs-pulses (length 400 fs, wavelength 520 nm) are tightly focused with a Schwarzschild microscope objective to ablate the sample surface. The optical emission of laser-induced plasma (LIP) is collected by the objective and measured with an echelle spectrometer equipped with an intensified charge-coupled device camera. A second fs-laser pulse (1040 nm) in orthogonal beam arrangement is reheating the LIP. The optimization of the experimental setup and measurement parameters enables us to record single-pulse fs-LIBS spectra of 5 nm thin metal layers with an ablated mass per pulse of 100 femtogram (fg) for Cu and 370 fg for Ag films. The orthogonal double-pulse fs-LIBS enhances the recorded emission line intensities (two to three times) and improves the contrast of chemical images in comparison to single-pulse measurements. The size of ablation craters (diameters as small as 1.5 µm) is not increased by the second laser pulse. The combination of minimally invasive sampling by a tightly focused low-energy fs-pulse and of strong enhancement of plasma emission by an orthogonal high-energy fs-pulse appears promising for future LIBS chemical imaging with high spatial resolution and with high spectrochemical sensitivity.

High spatial resolution in laser-induced breakdown spectroscopy of expanding plasmas

2005 ◽  
Vol 60 (7-8) ◽  
pp. 915-919 ◽  
Author(s):  
J. Siegel ◽  
G. Epurescu ◽  
A. Perea ◽  
F.J. Gordillo-Vázquez ◽  
J. Gonzalo ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Laser Induced Breakdown Spectroscopy ◽  
Breakdown Spectroscopy ◽  
Laser Induced Breakdown
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