scholarly journals Clinicopathological Characteristics of Hepatocellular Carcinoma with Microscopic Portal Venous Invasion and the Role of Anatomical Liver Resection in These Cases

2017 ◽  
Vol 41 (8) ◽  
pp. 2087-2094 ◽  
Author(s):  
Shingo Shimada ◽  
Toshiya Kamiyama ◽  
Hideki Yokoo ◽  
Tatsuya Orimo ◽  
Kenji Wakayama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Venous Invasion ◽  
Clinicopathological Characteristics ◽  
Anatomical Liver Resection

Development and Validation of Prognostic Nomograms Predicting Recurrence and Survival in Patients with Solitary Hepatocellular Carcinoma Following Curative Liver Resection

2021 ◽  
Author(s):  
Xinxin Chen ◽  
Wenxia Qiu ◽  
Xuekun Xie ◽  
Zefeng Chen ◽  
Zhiwei Han ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Cox Regression ◽  
Disease Free Survival ◽  
Clinicopathological Characteristics ◽  
Tumor Diameter ◽  
Cox Regression Analysis ◽  
Tumor Capsule ◽  
Calibration Curves ◽  
Solitary Hepatocellular Carcinoma

Abstract Background: This work was designed to establish and verify our nomograms integrating clinicopathological characteristics with hematological biomarkers to predict both disease-free survival (DFS) and overall survival (OS) in solitary hepatocellular carcinoma (HCC) patients following hepatectomy.Methods: We scrutinized the data retrospectively from 414 patients with a clinicopathological diagnosis of solitary HCC from Guangxi Medical University Cancer Hospital (Nanning, China) between January 2004 and December 2012. Following the random separation of the samples in a 7:3 ratio into the training set and validation set, the former set was assessed by Cox regression analysis to develop two nomograms to predict the 1-year and 3-year DFS and OS (3-years and 5-years). This was followed by discrimination and calibration estimation employing Harrell’s C-index (C-index) and calibration curves, while the internal validation was also assessed.Results: In the training cohort, the tumor diameter, tumor capsule, macrovascular invasion, and alpha-fetoprotein (AFP) were included in the DFS nomogram. Age, tumor diameter, tumor capsule, macrovascular invasion, microvascular invasion, and aspartate aminotransferase (AST) were included in the OS nomogram. The C-index was 0.691 (95% CI: 0.644-0.738) for the DFS-nomogram and 0.713 (95% CI: 0.670-0.756) for the OS-nomogram. The survival probability calibration curves displayed a fine agreement between the predicted and observed ranges in both data sets. Conclusion: Our nomograms combined clinicopathological features with hematological biomarkers to emerge effective in predicting the DFS and OS in solitary HCC patients following curative liver resection. Therefore, the potential utility of our nomograms for guiding individualized treatment clinically and monitor the recurrence monitoring in these patients.

Clinical Impact of Anatomical Liver Resection for Hepatocellular Carcinoma with Pathologically Proven Portal Vein Invasion

2015 ◽  
Vol 40 (2) ◽  
pp. 402-411 ◽  
Author(s):  
Takatsugu Matsumoto ◽  
Keiichi Kubota ◽  
Taku Aoki ◽  
Yukihiro Iso ◽  
Masato Kato ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Portal Vein ◽  
Clinical Impact ◽  
Portal Vein Invasion ◽  
Anatomical Liver Resection

Tu1046 Clinical Impact of Anatomical Liver Resection for Solitary Hepatocellular Carcinoma

2013 ◽  
Vol 144 (5) ◽  
pp. S-1040
Author(s):  
Taku Iida ◽  
Hiroaki Terajima ◽  
Yoichiro Uchida ◽  
Shugo Ueda
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Clinical Impact ◽  
Solitary Hepatocellular Carcinoma ◽  
Anatomical Liver Resection

scholarly journals Laparoscopically anatomical versus non-anatomical liver resection for large hepatocellular carcinoma

HPB ◽  
2020 ◽  
Vol 22 (1) ◽  
pp. 136-143
Author(s):  
HongWei Xu ◽  
Fei Liu ◽  
XiangYong Hao ◽  
YongGang Wei ◽  
Bo Li ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Large Hepatocellular Carcinoma ◽  
Anatomical Liver Resection

The Role of Liver Resection for the Treatment of Hepatocellular Carcinoma

Liver Cancers ◽  
2018 ◽  
pp. 83-97
Author(s):  
Mikael H. Sodergren ◽  
Dinesh Sharma
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection

The role of liver resection in the management of intermediate and advanced stage hepatocellular carcinoma. A systematic review

2018 ◽  
Vol 44 (2) ◽  
pp. 195-208 ◽  
Author(s):  
G.K. Glantzounis ◽  
A. Paliouras ◽  
M.-C. Stylianidi ◽  
H. Milionis ◽  
P. Tzimas ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Liver Resection ◽  
Advanced Stage

Long-term results of laparoscopic liver resection for the primary treatment of hepatocellular carcinoma: role of the surgeon in anatomical resection

2018 ◽  
Vol 32 (11) ◽  
pp. 4481-4490 ◽  
Author(s):  
Woo-Hyoung Kang ◽  
Ki-Hun Kim ◽  
Dong-Hwan Jung ◽  
Gil-Chun Park ◽  
Seok-Hwan Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Laparoscopic Liver Resection ◽  
Primary Treatment ◽  
Long Term Results ◽  
Anatomical Resection

scholarly journals Bridging and downstaging role of transarterial radioembolization (TARE) for expected small remnant volume after liver resection in hepatocellular carcinoma

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S424
Author(s):  
J.-M. Lee ◽  
K.-S. Suh ◽  
S.K. Hong ◽  
K.C. Yoon ◽  
J.-H. Cho ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Transarterial Radioembolization

scholarly journals Clinicopathological Significance of MicroRNA-20b Expression in Hepatocellular Carcinoma and Regulation of HIF-1αand VEGF Effect on Cell Biological Behaviour

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Tong-min Xue ◽  
Li-de Tao ◽  
Miao Zhang ◽  
Jie Zhang ◽  
Xia Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Proportional Hazards ◽  
Clinicopathological Characteristics ◽  
Cox Proportional Hazards ◽  
Biological Behaviour ◽  
Proportional Hazards Regression ◽  
Kaplan Meier ◽  
Clinicopathological Significance ◽  
Tumor Types

miRNA-20b has been shown to be aberrantly expressed in several tumor types. However, the clinical significance of miRNA-20b in the prognosis of patients with hepatocellular carcinoma (HCC) is poorly understood, and the exact role of miRNA-20b in HCC remains unclear. The aim of the present study was to investigate the association of the expression of miR-20b with clinicopathological characteristics and overall survival of HCC patients analyzed by Kaplan-Meier analysis and Cox proportional hazards regression models. Meanwhile, the HIF-1αand VEGF targets of miR-20b have been confirmed. We found not only miR-20b regulation of HIF-1αand VEGF in normal but also regulation of miR-20b in hypoxia. This mechanism would help the tumor cells adapt to the different environments thus promoting the tumor invasion and development. The whole study suggests that miR-20b, HIF-1α, and VEGF serve as a potential therapeutic agent for hepatocellular carcinoma.

scholarly journals Is anatomical liver resection in patients with hepatocellular carcinoma always correct?

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e238
Author(s):  
H.Y. Jeong ◽  
J.K. Kim ◽  
J.Y. Kim ◽  
G.H. Choi ◽  
J.S. Park ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Resection ◽  
Anatomical Liver Resection
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