Prospective comparison of 18-FDG PET/CT and whole-body diffusion-weighted MRI in the assessment of multiple myeloma

2020 ◽  
Vol 99 (12) ◽  
pp. 2869-2880
Author(s):  
Charles Mesguich ◽  
Cyrille Hulin ◽  
Valerie Latrabe ◽  
Axelle Lascaux ◽  
Laurence Bordenave ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Fdg Pet ◽  
Whole Body ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Prospective Comparison ◽  
Pet Ct ◽  
Fdg Pet Ct

Evaluation of staging and early response to chemotherapy with whole-body diffusion-weighted MRI in malignant lymphoma patients: A comparison with FDG-PET/CT

2014 ◽  
Vol 41 (6) ◽  
pp. 1601-1607 ◽  
Author(s):  
Kazunobu Tsuji ◽  
Shinji Kishi ◽  
Tatsuro Tsuchida ◽  
Takahiro Yamauchi ◽  
Satoshi Ikegaya ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Fdg Pet ◽  
Early Response ◽  
Whole Body ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Response To Chemotherapy ◽  
Pet Ct ◽  
Fdg Pet Ct

Newly Diagnosed Lymphoma: Initial Results With Whole-Body T1-Weighted, STIR, and Diffusion-Weighted MRI Compared With 18F-FDG PET/CT

2011 ◽  
Vol 196 (3) ◽  
pp. 662-669 ◽  
Author(s):  
Henriëtte M. E. Quarles van Ufford ◽  
Thomas C. Kwee ◽  
Frederik J. Beek ◽  
Maarten S. van Leeuwen ◽  
Taro Takahara ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Whole Body ◽  
Newly Diagnosed ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
And Diffusion ◽  
Initial Results

Whole-Body Diffusion-Weighted MRI Compared to 18 FFDG PET/CT in Initial Staging and Therapy Response Assessment of Hodgkin Lymphoma in Pediatric Patients

2020 ◽  
Vol 71 (2) ◽  
pp. 217-225 ◽  
Author(s):  
Gali Shapira-Zaltsberg ◽  
Nagwa Wilson ◽  
Esther Trejo Perez ◽  
Lesleigh Abbott ◽  
Stephen Dinning ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Pediatric Patients ◽  
Whole Body ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Initial Staging

Purpose: The aim of our study was to compare whole-body diffusion-weighted MRI (WB-DWI-MRI) to fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in the assessment of initial staging and treatment response in pediatric patients with Hodgkin lymphoma. Materials and Methods: This prospective study comprised 11 children with Hodgkin lymphoma. Whole-body DWI-MRI and FDG-PET/CT were obtained at baseline and after 2 cycles of chemotherapy. Two radiologists measured the apparent diffusion coefficient (ADC) values of the sites of involvement agreed upon in consensus and 1 nuclear medicine physician assessed the PET/CT. Reliability of radiologists’ ratings was assessed by intraclass correlation coefficients (ICC2,1). The sensitivity and positive predictive value (PPV) of DW-MRI relative to PET/CT were calculated for nodal and extranodal sites. The patients were staged according to both modalities. Association of treatment responses was assessed through the Pearson correlation between the ADC ratios and the change standardized uptake value (SUV) between baseline and follow-up. Results: There was good agreement between the raters for nodal and extranodal ADC measurements. The sensitivity and PPV of DW-MRI relative to PET/CT of nodal disease was 0.651 and 1.0, respectively, at baseline, and 0.697 and 0.885 at follow-up. The sensitivity and PPV of extranodal disease were 0.545 and 0.6 at baseline, and 0.167 and 0.333 at follow-up. Diffusion-weighted MRI determined correct tumor stage in 8 of 11 examinations. There was poor correlation between the ADC ratios and the absolute change in SUV between baseline and follow-up (0.348). Conclusion: Our experience showed that WB-DWI-MRI is inferior to PET/CT for initial staging and assessment of treatment response of Hodgkin lymphoma in pediatric patients.

Whole-body diffusion-weighted MRI and 18F-FDG PET/CT can discriminate between different lymphoma subtypes

2015 ◽  
Vol 70 (11) ◽  
pp. 1229-1236 ◽  
Author(s):  
F. Mosavi ◽  
C. Wassberg ◽  
J. Selling ◽  
D. Molin ◽  
H. Ahlström
Keyword(s):  
Fdg Pet ◽  
Whole Body ◽  
Diffusion Weighted Mri ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Comparison of the diagnostic performance and impact on management of 18F-FDG PET/CT and whole-body MRI in multiple myeloma

2021 ◽  
Author(s):  
Olwen Westerland ◽  
◽  
Ashik Amlani ◽  
Christian Kelly-Morland ◽  
Michal Fraczek ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Clinical Data ◽  
Bone Disease ◽  
Fdg Pet ◽  
Diagnostic Performance ◽  
Whole Body ◽  
Bone Lesions ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Purpose Comparative data on the impact of imaging on management is lacking for multiple myeloma. This study compared the diagnostic performance and impact on management of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and whole-body magnetic resonance imaging (WBMRI) in treatment-naive myeloma. Methods Forty-six patients undergoing 18F-FDG PET/CT and WBMRI were reviewed by a nuclear medicine physician and radiologist, respectively, for the presence of myeloma bone disease. Blinded clinical and imaging data were reviewed by two haematologists in consensus and management recorded following clinical data ± 18F-FDG PET/CT or WBMRI. Bone disease was defined using International Myeloma Working Group (IMWG) criteria and a clinical reference standard. Per-patient sensitivity for lesion detection was established. McNemar test compared management based on clinical assessment ± 18F-FDG PET/CT or WBMRI. Results Sensitivity for bone lesions was 69.6% (32/46) for 18F-FDG PET/CT (54.3% (25/46) for PET component alone) and 91.3% (42/46) for WBMRI. 27/46 (58.7%) of cases were concordant. In 19/46 patients (41.3%) WBMRI detected more focal bone lesions than 18F-FDG PET/CT. Based on clinical data alone, 32/46 (69.6%) patients would have been treated. Addition of 18F-FDG PET/CT to clinical data increased this to 40/46 (87.0%) patients (p = 0.02); and WBMRI to clinical data to 43/46 (93.5%) patients (p = 0.002). The difference in treatment decisions was not statistically significant between 18F-FDG PET/CT and WBMRI (p = 0.08). Conclusion Compared to 18F-FDG PET/CT, WBMRI had a higher per patient sensitivity for bone disease. However, treatment decisions were not statistically different and either modality would be appropriate in initial staging, depending on local availability and expertise.

Whole-body MRI for initial staging of paediatric lymphoma: prospective comparison to an FDG-PET/CT-based reference standard

2014 ◽  
Vol 24 (5) ◽  
pp. 1153-1165 ◽  
Author(s):  
Annemieke S. Littooij ◽  
Thomas C. Kwee ◽  
Ignasi Barber ◽  
Claudio Granata ◽  
Malou A. Vermoolen ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Whole Body ◽  
Reference Standard ◽  
Whole Body Mri ◽  
Prospective Comparison ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Initial Staging

scholarly journals Staging of Primary Abdominal Lymphomas: Comparison of Whole-Body MRI with Diffusion-Weighted Imaging and18F-FDG-PET/CT

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Alessandro Stecco ◽  
Francesco Buemi ◽  
Martina Quagliozzi ◽  
Mariangela Lombardi ◽  
Alberto Santagostino ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Weighted Kappa ◽  
Whole Body ◽  
Gastrointestinal Lymphoma ◽  
Predictive Values ◽  
Whole Body Mri ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Kappa Agreement

Background. The purpose of this study was to compare the accuracy of whole-body MRI with diffusion-weighted sequences (WB-DW-MRI) with that of18F-FDG-PET/CT in the staging of patients with primary gastrointestinal lymphoma.Methods. This retrospective study involved 17 untreated patients with primary abdominal gastrointestinal lymphoma. All patients underwent18F-FDG-PET/CT and WB-DW-MRI. Histopathology findings or at least 6 months of clinical and radiological follow-up was the gold standard. The Musshoff-modified Ann Arbor system was used for staging, and diagnostic accuracy was evaluated on a per-node basis.Results. WB-DW-MRI exhibited 100% sensitivity, 96.3% specificity, and 96.1% and 100% positive and negative predictive values (PPV and NPV), respectively. The sensitivity, specificity, and PPV and NPV of PET/CT were 95.9%, 100%, and 100% and 96.4%, respectively. There were no statistically significant differences between the two techniquesp=0.05. The weighted kappa agreement statistics with a 95% confidence interval were 0.97 (0.95–0.99) between the two MRI readers and 0.87 (0.82–0.92) between the two methods.Conclusions. WB-DW-MRI appears to have a comparable diagnostic value to18F-FDG-PET/CT in staging patients with gastrointestinal lymphoma.

scholarly journals Cost-effectiveness of response evaluation after chemoradiation in patients with advanced oropharyngeal cancer using 18F–FDG-PET-CT and/or diffusion-weighted MRI

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Marjolein JE Greuter ◽  
Charlotte S Schouten ◽  
Jonas A Castelijns ◽  
Pim de Graaf ◽  
Emile FI Comans ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Fdg Pet ◽  
Oropharyngeal Cancer ◽  
Diffusion Weighted Mri ◽  
Response Evaluation ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct
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