Predictive value of ERCC2, ABCC2 and MMP2 of response and long-term survival in locally advanced head and neck cancer patients treated with chemoradiotherapy

2021 ◽  
Author(s):  
Goretti Duran ◽  
Raquel Cruz ◽  
Santiago Aguín ◽  
Francisco Barros ◽  
José María Giráldez ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Predictive Value ◽  
Locally Advanced ◽  
Advanced Head ◽  
Term Survival ◽  
Long Term Survival

Long-term survival of resectable subset after induction chemotherapy in patients with locally advanced head and neck cancer

Head & Neck ◽  
2008 ◽  
Vol 30 (3) ◽  
pp. 346-350 ◽  
Author(s):  
Yo-Han Cho ◽  
Se Hoon Lee ◽  
Dong-Wan Kim ◽  
Hong-Gyun Wu ◽  
J. Hun Hah ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Advanced Head ◽  
Term Survival ◽  
Long Term Survival

P180 PERIOPERATIVE ENTERAL ARGININE SUPPLEMENTATION IN HEAD AND NECK CANCER PATIENTS IMPROVES LONG TERM SURVIVAL

2008 ◽  
Vol 3 ◽  
pp. 105
Author(s):  
N. Buijs ◽  
M.A.E. van Bokhorst-de van der Schueren ◽  
J.A.E. Langius ◽  
C.R. Leemans ◽  
M.A.R. Vermeulen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Term Survival ◽  
Long Term Survival ◽  
Arginine Supplementation

Long-Term Survival of Dental Implants in Irradiated Head and Neck Cancer Patients: A Retrospective Analysis

2018 ◽  
Vol 126 (3) ◽  
pp. e46
Author(s):  
Daniel Henrique Koga ◽  
Camila Lopes Cardoso ◽  
Anthony Froy Benites Condezo ◽  
Giuliano Issa Cossolin ◽  
Marcos Martins Curi
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Retrospective Analysis ◽  
Cancer Patients ◽  
Dental Implants ◽  
Neck Cancer ◽  
Term Survival ◽  
Long Term Survival

Compliance and Outcomes in Locally Advanced Head and Neck Cancer Patients Treated with Alternating Chemoradiotherapy in Clinical Practice

2003 ◽  
Vol 89 (1) ◽  
pp. 20-25 ◽  
Author(s):  
Vittorio Franciosi ◽  
Marco Fumagalli ◽  
Luciana Biscari ◽  
Roberto Martinelli ◽  
Teore Ferri ◽  
...  
Keyword(s):  
Overall Survival ◽  
Head And Neck Cancer ◽  
Clinical Practice ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Locally Advanced ◽  
Hematologic Toxicity ◽  
Advanced Head ◽  
Grade 3

Background and Aims To evaluate the feasibility in clinical practice of alternating chemo-radiotherapy in locally advanced head and neck cancer patients. Patients and Methods From August 1993 to April 1998 at the Division of Medical Oncology of Parma, 48 consecutive patients were observed, and 38 (79%) started the Merlano chemo-radiotherapy. The characteristics of the patients were: males (32, 84%); median age, 57 years; PS <2 (32, 84%). The primary sites were the oropharynx (18, 47%), oral cavity (8, 21%), hypopharynx (7, 19%), larynx (5, 13%); stage IV disease was present in 29 (76%) patients. Twenty-five (66%) patients were married, and 24 (63%) resided outside of the city. Results The compliance was very low: 21 patients (55%) performed all the programmed cycles of chemotherapy, whereas only 5 patients (13%) performed the chemo-radiotherapy at full doses without any delay. The objective responses were 3 (8%) complete and 21 (55%) complete plus partial responses. Failures were 2 (5%) stable disease and 2 (5%) progressive disease, and the response was not assessable in 10 (26%). The median duration of the response was 8 months. The median overall survival and the time to progression were 18 and 13 months, respectively; the 5-year overall and relapse-free survival were 36% and 26%, respectively. Nine (24%) patients were still alive as of August 30, 2001, 8 (21%) of them without progression. Twenty-six patients (68%) died with a local-regional relapse. One patient (3%) died for a second cancer. Grade 3–4 hematologic toxicity was leukopenia (n = 25, 66%) and thrombocytopenia (n = 9, 24%); grade 3–4 non-hematologic toxicity was diarrhea (n = 3, 8%) and mucositis (n = 2, 5%). Two patients (5%) died for intestinal infarction and perforation possibly related to treatment. Conclusions Compliance to the chemo-radiotherapy was very poor. The response rate was lower than that reported in clinical trials, whereas overall survival was comparable. The alternating chemo-radiotherapy is a very complex treatment that cannot be easily applied in clinical practice; a careful selection of patients is mandatory not only considering oncologic and medical criteria, but also the level of awareness of the patient and his family.

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