Synthesis of poly(2-ethyl-2-oxazoline)-block-polypeptide copolymers by combination of ring-opening polymerization of oxazoline and polycondensation of activated urethane derivatives of α-amino acids

2018 ◽  
Vol 75 (11) ◽  
pp. 5075-5088 ◽  
Author(s):  
Koksal Karadag ◽  
Shuhei Yamada ◽  
Takeshi Endo
Keyword(s):  
Amino Acids ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Derivatives Of

Biodegradable Polymers Derived from Amino Acids for Biological Applications

2010 ◽  
Vol 76 ◽  
pp. 30-35 ◽  
Author(s):  
Naomi Cohen-Arazi ◽  
Ilanit Hagag ◽  
Michal Kolitz ◽  
Abraham J. Domb ◽  
Jeoshua Katzhendler
Keyword(s):  
Amino Acids ◽  
Molecular Weight ◽  
Ring Opening ◽  
Building Blocks ◽  
Ring Opening Polymerization ◽  
Microwave Assisted Synthesis ◽  
Hydroxy Acids ◽  
Natural Amino Acids ◽  
Direct Condensation ◽  
Positively Charged

Optically active α-hydroxy acids derived from amino acids have been synthesized and polymerized into new biodegradable polyesters. The variety of functional side chains enables the design of positively charged, negatively charged, hydrophobic and hydrophilic chiral building blocks or any combination of these constituents. Hydroxy acids of 15 natural amino acids were prepared with retention of configuration using a straightforward and reliable method of diazotization of α-amino acids. Polyesters were synthesized from these hydroxy acids by a number of methods: direct condensation in bulk, microwave assisted synthesis and ring opening polymerization. The molecular weight of the prepared polymers ranges between 2000 to 5000Da for the direct condensation and the microwave methods, whereas the ring opening polymerization results in high molecular weight polymers (20000 to 30000Da). The polymers were analyzed for their optical activity (Circular Dichroism Spectroscopy), thermal properties (DSC), solubility, molecular weight and polydispersity (GPC), and aqueous degradation. These polymers were tested for their compatibility to neuronal cells growth and differentiation.

Ring opening polymerization of α-amino acids: advances in synthesis, architecture and applications of polypeptides and their hybrids

2020 ◽  
Vol 49 (14) ◽  
pp. 4737-4834 ◽  
Author(s):  
Alicia Rasines Mazo ◽  
Stephanie Allison-Logan ◽  
Fatemeh Karimi ◽  
Nicholas Jun-An Chan ◽  
Wenlian Qiu ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ring Opening ◽  
Biomedical Applications ◽  
Architectural Design ◽  
Ring Opening Polymerization ◽  
Comprehensive Overview

This review provides a comprehensive overview of the latest advances in the synthesis, architectural design and biomedical applications of polypeptides and their hybrids.

scholarly journals Well-defined (co)polypeptides bearing pendant alkyne groups

2016 ◽  
Vol 7 (21) ◽  
pp. 3487-3491 ◽  
Author(s):  
Wei Zhao ◽  
Yves Gnanou ◽  
Nikos Hadjichristidis
Keyword(s):  
Amino Acids ◽  
Hydrogen Bonding ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Metal Free

A novel metal-free strategy, using hydrogen-bonding catalytic ring opening polymerization of alkyne-functionalized N-carboxy anhydrites of α-amino acids, was developed for the synthesis of well-defined polypeptides bearing pendant alkyne groups.

scholarly journals Towards a selective synthetic route for cobalt amino acid complexes and their application in ring opening polymerization of rac-lactide

RSC Advances ◽  
2021 ◽  
Vol 11 (27) ◽  
pp. 16326-16338
Author(s):  
Andrés Castro Ruiz ◽  
Krishna K. Damodaran ◽  
Sigridur G. Suman
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Oxidation States ◽  
Synthetic Route ◽  
Coordination Properties ◽  
Amino Acid Complexes ◽  
Ligand Coordination

Catalysts based on Co, amino acids, and 2,2-bipyridine present an attractive and economic alternative in ring opening polymerization, and possess advantageous ligand coordination properties combined with a variety of accessible oxidation states and coordination geometries.

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