Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications

2004 ◽  
Vol 14 (4) ◽  
pp. 559-578 ◽  
Author(s):  
Peter Reimer ◽  
G�nter Schneider ◽  
Wolfgang Schima
Keyword(s):  
Contrast Agents ◽  
Clinical Development ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Hepatobiliary Contrast Agents ◽  
Contrast Enhanced Mri

OPTIMAL DOSE OF MR CONTRAST AGENT IN T1-WEIGHTED MRI

2004 ◽  
Vol 16 (06) ◽  
pp. 331-336 ◽  
Author(s):  
C-C HSIAO ◽  
J-C JAO ◽  
Y-N TING ◽  
H-B PAN ◽  
P-C CHEN
Keyword(s):  
Contrast Agents ◽  
Pulse Sequences ◽  
Optimal Dose ◽  
Mri Contrast Agents ◽  
Lesion Detection ◽  
The Body ◽  
Rapid Expansion ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Contrast Enhanced Mri

Nowadays magnetic resonance imaging (MRI) has been commonly used in many indications. Concurrent development of MRI contrast agents has aided the rapid expansion and increased clinical efficacy. The use of contrast agents can improve lesion detection and characterization. With the contrast enhancement, lesion conspicuity is dramatically increased. Therefore, contrast enhanced MRI could provide more accurate diagnosis and be helpful for further therapy. The routinely used dose of contrast agents suggested by the documents only relies on the body weight of the subject. However, the relationship between the signal enhancement and the dose of contrast agents needs to be further investigated in order to achieve the maximum enhancement from optimal dose of the contrast agents. The aim of this study is to obtain the optimal dose of two contrast agents (Magnivist and Omniscan) for various T1-weighted pulse sequences (SE, SPGR, 2D TOF and 3D TOF) and various coils (body coil, NV array coil and head coil). The optimal dose is defined as achieving the MR images with the highest enhancement. The results show that there are significant differences in optimal dose among various pulse sequences. However, there are no significant differences in optimal dose among various coils and these two contrast agents. The advantage of finding optimal dose is to minimize dose and potential toxicity, and furthermore to decrease the cost of contrast agents. This study was done on a phantom, and it is expected to provide useful information to the contrast enhanced MRI in the routine clinical diagnosis and research in the future.

Dynamic contrast enhanced MRI of mouse fibrosarcoma using small-molecular and novel macromolecular contrast agents

2007 ◽  
Vol 23 (3-4) ◽  
pp. 85-90 ◽  
Author(s):  
Teodora Ivanuša ◽  
Katarina Beravs ◽  
Jure Medič ◽  
Igor Serša ◽  
Gregor Serša ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Contrast Enhanced Mri

Delayed contrast-enhanced MRI of cartilage: Comparison of nonionic and ionic contrast agents

2010 ◽  
Vol 64 (5) ◽  
pp. 1267-1273 ◽  
Author(s):  
Wei Li ◽  
Rachel Scheidegger ◽  
Ying Wu ◽  
Robert R. Edelman ◽  
Michelle Farley ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Ionic Contrast ◽  
Contrast Enhanced Mri
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