Effectiveness of percutaneous vacuum-assisted excision (VAE) of breast lesions of uncertain malignant potential (B3 lesions) as an alternative to open surgical biopsy

2021 ◽  
Author(s):  
Elisabetta Giannotti ◽  
Jonathan J. James ◽  
Yan Chen ◽  
Rachel Sun ◽  
Amanjot Karuppiah ◽  
...  
Keyword(s):  
Malignant Potential ◽  
Breast Lesions ◽  
Uncertain Malignant Potential ◽  
Surgical Biopsy ◽  
B3 Lesions ◽  
Open Surgical Biopsy

Heterogeneous risk profiles among B3 breast lesions of uncertain malignant potential

2019 ◽  
Vol 106 (2) ◽  
pp. 115-125 ◽  
Author(s):  
Paolo Orsaria ◽  
Antonella Grasso ◽  
Rita Carino ◽  
Emanuele Caredda ◽  
Matteo Sammarra ◽  
...  
Keyword(s):  
Ductal Carcinoma ◽  
Phyllodes Tumor ◽  
Malignant Potential ◽  
Flat Epithelial Atypia ◽  
Breast Lesions ◽  
Uncertain Malignant Potential ◽  
Predictive Values ◽  
Ductal Hyperplasia ◽  
B3 Lesions ◽  
Risk Of Malignancy

Background: Most cases of breast lesions of uncertain malignant potential (B3) undergo surgical intervention. We aimed to analyze the outcome of B3 lesion subtypes in a large series of screen-detected cases. Methods: We screened 2,986 core needle biopsies to classify B3 lesions. Positive predictive values (PPVs) for malignancy were calculated for a comprehensive risk characterization according to clinicopathologic and morphologic variables. Results: B3 lesions comprised 35% atypical ductal hyperplasia (PPV = 20%), 16.7% flat epithelial atypia (PPV = 12%), 22.7% lobular neoplasia (PPV = 16.2%), 9% papillary lesion (PPV = 18.5%), 8.6% phyllodes tumor (PPV = 3.8%), and 8% radial scars (PPV = 4.1%) based on histopathologic diagnosis. Upgrade rates were 15.9% for calcifications, 13.7% for mass lesions, and 16.7% for architectural deformities, with 8.3% of malignant lesions classified as ductal carcinoma in situ and 6.7% as invasive cancers (PPV = 15%). Conclusion: B3 lesions entail a heterogeneous risk of malignancy, and careful radiologic–pathologic correlation is required for optimal treatment.

scholarly journals Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions)

2018 ◽  
Vol 174 (2) ◽  
pp. 279-296 ◽  
Author(s):  
Christoph J. Rageth ◽  
Elizabeth A. M. O’Flynn ◽  
Katja Pinker ◽  
Rahel A. Kubik-Huch ◽  
Alexander Mundinger ◽  
...  
Keyword(s):  
Consensus Conference ◽  
Malignant Potential ◽  
Uncertain Malignant Potential ◽  
International Consensus ◽  
B3 Lesions ◽  
Second International

scholarly journals Breast Lesions of Uncertain Malignant Potential: A Challenge for Surgeons

2012 ◽  
Vol 1 (1) ◽  
Author(s):  
Nancy Deslauriers ◽  
Sidéris Lucas ◽  
Dufresne Michel-Pierre ◽  
Mitchell Andrew ◽  
Drolet Pierre ◽  
...  
Keyword(s):  
Malignant Potential ◽  
Breast Lesions ◽  
Uncertain Malignant Potential
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