Remotely programmed sacral neuromodulation for the treatment of patients with refractory overactive bladder: a prospective randomized controlled trial evaluating the safety and efficacy of a novel sacral neuromodulation device

2019 ◽  
Vol 37 (11) ◽  
pp. 2481-2492 ◽  
Author(s):  
Yaoguang Zhang ◽  
Peng Zhang ◽  
Xiaojun Tian ◽  
Guoqing Chen ◽  
Yan Li ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Overactive Bladder ◽  
Sacral Neuromodulation ◽  
Controlled Trial ◽  
Safety And Efficacy ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial

Prospective, Randomized, Controlled Trial of a Hemostatic Sealant in Children Undergoing Adenotonsillectomy

2007 ◽  
Vol 137 (3) ◽  
pp. 454-458 ◽  
Author(s):  
Stephen H. Jo ◽  
Ronald A. Mathiasen ◽  
Deepak Gurushanthaiah
Keyword(s):  
Randomized Controlled Trial ◽  
Blood Loss ◽  
Postoperative Morbidity ◽  
Controlled Trial ◽  
Safety And Efficacy ◽  
Randomized Controlled ◽  
Pain Medications ◽  
Prospective Randomized Controlled Trial ◽  
Cold Knife ◽  
To Receive

OBJECTIVES: To evaluate the efficacy of Floseal as a hemostatic sealant compared to traditional electrocautery hemostasis after cold knife adenotonsillectomy. STUDY DESIGN: Prospective, randomized, controlled trial of 68 consecutive patients undergoing cold steel adenotonsillectomy. Patients were randomized to receive either Floseal (FS) or electrocautery (EC) for hemostasis. RESULTS: FS patients had shorter operative times than EC patients (16 min vs 31.2 min, P < 0.0001) and less blood loss (49.2 mL vs 70.8 mL, P < 0.05). Four EC patients were crossed over to Floseal when adequate hemostasis could not be achieved in the adenoid bed. No Floseal patients were crossed over. FS patients had significantly less pain on postoperative days two through 11 ( P < 0.05) and less use of narcotic pain medications over the first 10 postoperative days ( P < 0.05). FS patients also had a faster return to regular diet (5.5 days vs 7.9 days, P < 0.01) and activity (5.3 days vs 7.8 days, P < 0.01) as compared to the EC patients. There were no significant complications in either group. CONCLUSIONS: Floseal is safe and efficacious, and decreases postoperative morbidity as compared to electrocautery hemostasis after cold steel adenotonsillectomy. SIGNIFICANCE: This study demonstrates the safety and efficacy of Floseal as a hemostatic method in children undergoing adenotonsillectomy.

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