Birth prevalence of neural tube defects: a population-based study in South-Eastern Hungary

AbstractIn a large population-based study in Northern Ireland during the period 1974-1979, the rate of anencephalus in twins (9.1/10,000) was found to be less than that in singletons (24.3/10,000). This finding is in contrast with most other studies and the possibility of underascertainment of twin cases is considered, but it is concluded that chance is the likeliest explanation. The rate of spina bifida in twins (36.4/10,000) was similar to that in singletons (31.9/10,000). All of the twins with anencephalus were female and from pairs of like sex. Rates of spina bifida in twins from pairs of the two sex types were similar but, unusually, there was a male preponderance. As in previous studies, the great majority of twins with NTDs had unaffected cotwins.

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Prevalence at Birth of Neural Tube Defects in California: A Population-Based Study

Neuroepidemiology ◽

10.1016/b978-0-12-504220-8.50017-9 ◽

1993 ◽

pp. 213-232

Author(s):

Margarita E. Villarino ◽

Amanda L. Golbeck ◽

Craig A. Molgaard

Keyword(s):

Neural Tube ◽

Neural Tube Defects ◽

Population Based ◽

Population Based Study

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Long term trends in prevalence of neural tube defects in Europe: population based study

BMJ ◽

10.1136/bmj.h5949 ◽

2015 ◽

pp. h5949 ◽

Cited By ~ 103

Author(s):

Babak Khoshnood ◽

Maria Loane ◽

Hermien de Walle ◽

Larraitz Arriola ◽

Marie-Claude Addor ◽

...

Keyword(s):

Neural Tube ◽

Neural Tube Defects ◽

Population Based ◽

Population Based Study ◽

Long Term Trends

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Congenital Anomalies in Twins in Northern Ireland. I: Anomalies in General and Specific Anomalies Other Than Neural Tube Defects and of the Cardiovascular System, 1974–1979

Acta geneticae medicae et gemellologiae twin research ◽

10.1017/s0001566000002786 ◽

1989 ◽

Vol 38 (1-2) ◽

pp. 1-16 ◽

Cited By ~ 7

Author(s):

J. Little ◽

N.C. Nevin

Keyword(s):

Northern Ireland ◽

Cardiovascular System ◽

Neural Tube ◽

Neural Tube Defects ◽

Congenital Anomalies ◽

Large Scale ◽

Population Based ◽

Multiple Sources ◽

Population Based Study ◽

Scale Population

AbstractData are presented from a large-scale population-based study in Northern Ireland, in which multiple sources of ascertainment were used. As found in other studies, the overall prevalence at birth of congenital anomalies amogst twins (285.4/10,000) was somewhat higher than the rate amongst singletons (241.8/10,000). Unlike in other studies, however, the rate amongst twins of like sex (287.8/10,000) was not markedly higher than that amongst twins of unlike sex (252.3/10,000). Problems of comparison between series are discussed.

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Impact of Prenatal Diagnosis on the Birth Prevalence of Neural Tube Defects, Atlanta, 1990-4991

PEDIATRICS ◽

10.1542/peds.96.5.880 ◽

1995 ◽

Vol 96 (5) ◽

pp. 880-883

Author(s):

Helen E. Roberts ◽

Cynthia A. Moore ◽

Janet D. Cragan ◽

Paul M. Fernhoff ◽

Muin J. Khoury

Keyword(s):

Prenatal Diagnosis ◽

Neural Tube ◽

Neural Tube Defects ◽

Fetal Death ◽

Population Based ◽

Congenital Defects ◽

Substantial Impact ◽

Birth Prevalence ◽

Live Births ◽

The Impact

Objective. To determine the impact of prenatal diagnosis on the birth prevalence of neural tube defects (NTDs) in Atlanta during 1990 through 1991. Methods. Live-born and stillborn infants with NTDs who were at least 20 weeks' gestation were ascertained by the Metropolitan Atlanta Congenital Defects Program (MACDP), a population-based birth defects registry. Prenatally diagnosed NTD-affected pregnancies were ascertained from the four perinatal centers and the three genetic laboratories operating in Atlanta during 1990 through 1991. Fetal death certificates were also reviewed for potential cases. Results. During 1990 through 1991, MACDP ascertained 59 NTD cases, for a birth prevalence of 0.77/1000 live births. During this period, an additional 28 NTD-affected pregnancies were detected prenatally and terminated before 20 weeks' gestation. The adjusted NTD rate during 1990 through 1991, which includes prenatally diagnosed cases, was 1.13/1000 live births. Conclusions. Prenatal diagnosis is making a substantial impact on the birth prevalence of NTDs in Atlanta. However, since NTD rates in Atlanta were 2 to 2.5 per 1000 live births in 1970, prenatal diagnosis and termination of pregnancy does not completely account for the declining rate of NTDs.

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