scholarly journals Preoperative intravenous iron treatment reduces postoperative complications and postoperative anemia in preoperatively anemic patients with colon carcinoma

2021 ◽  
Author(s):  
Mikael Kangaspunta ◽  
Jorma Mäkijärvi ◽  
Selja Koskensalo ◽  
Arto Kokkola ◽  
Perttu Arkkila ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Postoperative Complications ◽  
Blood Cell ◽  
Cancer Patients ◽  
Iron Supplementation ◽  
Intravenous Iron ◽  
Colon Resection ◽  
Iron Treatment ◽  
Red Blood Cell Transfusions ◽  
Intravenous Iron Supplementation

Abstract Purpose Anemia is common among patients with colorectal cancer and is associated with an increased risk of complications and poorer survival rate. The main objective of our study was to determine the effect of preoperative intravenous iron supplementation therapy on the need for red blood cell transfusions, other postoperative complications, and length of hospital stay in colon cancer patients undergoing colon resection. Methods In this retrospective cohort study, data were collected from medical records of all 549 colon carcinoma patients who underwent a colon resection in Helsinki University Hospital during the years 2017 and 2018. The patients were divided into two cohorts: one with anemic patients treated with preoperative intravenous iron supplementation therapy (180 patients) and one with anemic patients without preoperative intravenous iron supplementation therapy (138 patients). Non-anemic patients and patients requiring emergency surgery were excluded (231 patients). Results Patients treated with intravenous iron had less postoperative complications (33.9% vs. 45.9%, p = 0.045) and a lower prevalence of anemia at 1 month after surgery (38.7% vs. 65.3%, p < 0.01) when compared with patients without preoperative iv iron treatment. No difference was found in the amount of red blood cell transfusions, length of stay, or mortality between the groups. Conclusion This is the first study demonstrating a significant decrease in postoperative complications in anemic colon cancer patients receiving preoperative intravenous iron supplementation therapy. This treatment also diminishes the rate of postoperative anemia, which is often associated with a facilitated recovery.

scholarly journals Gastric Siderosis and Ulceration from Intravenous Iron Supplementation Manifesting as Chronic Upper Gastrointestinal Bleeding: A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Donald Ewing ◽  
Ava Brozovich ◽  
Ethan Burns ◽  
Gonzalo Acosta ◽  
Courtney Hatcher ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Blood Cell ◽  
Gastrointestinal Bleeding ◽  
Iron Supplementation ◽  
Upper Gastrointestinal Bleeding ◽  
Intravenous Iron ◽  
Deficiency Anemia ◽  
Red Blood Cell Transfusions ◽  
Upper Gastrointestinal ◽  
Intravenous Iron Supplementation

Iron deficiency is the most common etiology of anemia worldwide and is often managed with varying methods of iron supplementation. Although rare, oral iron supplementation can perpetuate iron deficiency anemia by causing gastric ulceration and upper gastrointestinal bleeding in high-risk populations. However, this complication has not been previously described with intravenous iron supplementation. We present a case of a 63-year-old male with severe iron deficiency anemia on biweekly intravenous iron infusions and weekly packed red blood cell transfusions who presented with melena over several months. Upper endoscopy demonstrated a clean-based gastric body ulcer and nonbleeding gastric varices. Histology of the gastric ulcer was suggestive of iron-induced gastric mucosal injury. This case demonstrates that frequent utilization of intravenous iron and packed red blood cell transfusions may predispose certain patients to the development of iron-induced gastritis and ulceration.

Intravenous iron supplementation after kidney transplantation

2012 ◽  
Vol 26 (4) ◽  
pp. 608-614 ◽  
Author(s):  
Benaya Rozen-Zvi ◽  
Anat Gafter-Gvili ◽  
Boris Zingerman ◽  
Rachel S. Levy-Drummer ◽  
Liora Levy ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Iron Supplementation ◽  
Intravenous Iron ◽  
Intravenous Iron Supplementation

scholarly journals Iatrogenic Iron Overload in an End Stage Renal Disease Patient

2020 ◽  
Vol 13 (2) ◽  
pp. 760-763
Author(s):  
Majd M. Aldwairi ◽  
Mohamed A. Yassin
Keyword(s):  
Renal Failure ◽  
Blood Cell ◽  
Iron Overload ◽  
Red Blood Cell ◽  
Disease Patient ◽  
Intravenous Iron ◽  
Human Erythropoietin ◽  
Red Blood Cell Transfusions ◽  
Stage Renal Disease ◽  
End Stage

Iron overload is a common complication in patients with chronic renal failure treated with dialysis prior to the availability of recombinant human erythropoietin therapy. Iron overload was the result of hypoproliferative erythroid marrow function coupled with the need for frequent red blood cell transfusions to manage symptomatic anemia. The repetitive use of intravenous iron with or without the use of red blood cell transfusions also contributed to iron loading and was associated with iron deposition in liver parenchymal and reticuloendothelial cells. Here we report a 56-year-old female with end-stage renal failure who underwent kidney transplant twice and found to have iatrogenic iron overload with excess intravenous iron treated conservatively.

scholarly journals The Impact of Comorbid Diabetes on Short-Term Postoperative Outcomes in Stage I/II Colon Cancer Patients Undergoing Open Colectomy

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Ko-Chao Lee ◽  
Kuan-Chih Chung ◽  
Hong-Hwa Chen ◽  
Kung-Chuan Cheng ◽  
Kuen-Lin Wu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Postoperative Complications ◽  
Hospital Mortality ◽  
Cancer Patients ◽  
Surgical Outcomes ◽  
Stage I ◽  
Open Colectomy ◽  
Short Term ◽  
Patients With Diabetes ◽  
The Impact

Purpose. This study aimed at evaluating the impact of comorbid diabetes on short-term postoperative outcomes in patients with stage I/II colon cancer after open colectomy. Methods. The data were extracted from the National Inpatient Sample database (2005-2010). Short-term surgical outcomes included in-hospital mortality, postoperative complications, and hospital length of stay. Results. A total of 49,064 stage I/II colon cancer patients undergoing open surgery were included, with a mean age of 70.35 years. Of them, 21.94% had comorbid diabetes. Multivariable analyses revealed that comorbid diabetes was significantly associated with a lower risk of in-hospital mortality and postoperative complications. Compared to patients without diabetes, patients with uncomplicated diabetes had lower percentages of in-hospital mortality and postoperative complications, but patients with complicated diabetes had a higher percentage of postoperative complications. In addition, patients with diabetes only, but not patients with diabetes and hypertension only, had a lower percentage of in-hospital mortality than patients without any comorbidity. Conclusion. The present results suggested the protective effects of uncomplicated diabetes on short-term surgical outcomes in stage I/II colon cancer patients after open colectomy. Further studies are warranted to confirm these unexpected findings and investigate the possible underlying mechanisms.

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