Neuropeptide Y as an indicator of successful alterations in sympathetic nervous activity after renal sympathetic denervation

2015 ◽  
Vol 104 (12) ◽  
pp. 1064-1071 ◽  
Author(s):  
Oliver Dörr ◽  
Sebastian Ewen ◽  
Christoph Liebetrau ◽  
Helge Möllmann ◽  
Luise Gaede ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Nervous Activity ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

Abstract 12006: Renal Sympathetic Denervation Improves Both Progressive Cardiac Remodeling and Renal Damages in Hypertensive Heart Failure Rats: Comparison With β Receptor Blockade

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Heitaro Watanabe ◽  
Yoshitaka Iwanaga ◽  
Yuki Miyaji ◽  
Hiromi Yamamoto ◽  
Shunichi Miyazaki
Keyword(s):  
Cardiac Remodeling ◽  
Adrenergic Receptor ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Sham Operation ◽  
Hypertensive Rats ◽  
Β Blocker ◽  
Sympathetic Nervous ◽  
Β Receptor ◽  
Renal Sympathetic

Background: Chronic activation of sympathetic-nervous system (SNS) is triggered and contributes to subsequent cardiac remodeling and the transition to heart failure (HF). Hypothesis: Renal sympathetic denervation (RDN) may affect the process by improving the renal damage and suppressing cardiac SNS in rat hypertensive HF model with renal injury. The effects may be comparable to those of chronic β blocker treatment. Methods and Results: In Dahl salt-sensitive hypertensive rats, RDN or sham operation was performed at hypertrophic stage (11 weeks). Vehicle (CONT) or β blocker, bisoprolol (BISO) was administrated in rats with sham operation. Both RDN and BISO did not alter blood pressure during the study, but BISO group showed the significantly less heart rate. In RDN and BISO groups, the median survival time was significantly improved from 18.9 (CONT) to 21.4 and 22.5 weeks, respectively (P < 0.01). Echocardiography showed the improvement of LV dilatation and fractional shortening, and histological analysis showed the amelioration of myocyte hypertrophy and fibrosis in RDN and BISO groups at HF stage (17 weeks). β1 adrenergic receptor and tyrosine hydroxylase expression in LV myocardium was significantly increased only in RDN group. In contrast, α1b, α1d, and α2c adrenergic receptor expressions were improved only in BISO group. Furthermore, renal histopathologic damages and function were ameliorated in the both treatment groups. It was accompanied by suppression of local endothelin-1 and renin mRNA expressions. Conclusions: Renal sympathetic denervation ameliorated progression of both myocardial and renal damages in the hypertensive rats, independent of blood pressure. The overall effects were similar with those of chronic β receptor blockade having the effects on heart rate and α adrenergic receptors’ expression. The underlying mechanism may be associated with preservation of myocardial sympathetic-nervous system and renal protection.

Direct measurement of renal sympathetic nervous activity in high-fat diet-related hypertensive rats

Life Sciences ◽  
2002 ◽  
Vol 71 (5) ◽  
pp. 537-546 ◽  
Author(s):  
Soh Iwashita ◽  
Mamoru Tanida ◽  
Naohito Terui ◽  
Youichirou Ootsuka ◽  
Miao Shu ◽  
...  
Keyword(s):  
Direct Measurement ◽  
High Fat Diet ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
High Fat ◽  
Hypertensive Rats ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

scholarly journals Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 802
Author(s):  
Thomas Rasmussen ◽  
Robin de Nijs ◽  
Lene Kjær Olsen ◽  
Anne-Lise Kamper ◽  
Lia Evi Bang ◽  
...  
Keyword(s):  
Sympathetic Activity ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Mibg Scintigraphy ◽  
Mibg Uptake ◽  
Post Transplantation ◽  
Donor Kidney ◽  
Sympathetic Nervous ◽  
Donor Kidney Transplantation ◽  
Renal Sympathetic

Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.

Sympathetic nervous activity in carriers of MC4R mutations

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
D Heutling ◽  
F Sayk ◽  
C Dodt ◽  
HL Fehm ◽  
A Hinney ◽  
...  
Keyword(s):  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

Renal Sympathetic Denervation Therapy in Hypertension

2018 ◽  
Vol 4 (3) ◽  
pp. 149-153
Author(s):  
V. Subash Chandra ◽  
N. Saleha
Keyword(s):  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Renal Sympathetic
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