scholarly journals Renal 123I-MIBG Uptake before and after Live-Donor Kidney Transplantation

Diagnostics ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 802
Author(s):  
Thomas Rasmussen ◽  
Robin de Nijs ◽  
Lene Kjær Olsen ◽  
Anne-Lise Kamper ◽  
Lia Evi Bang ◽  
...  
Keyword(s):  
Sympathetic Activity ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Mibg Scintigraphy ◽  
Mibg Uptake ◽  
Post Transplantation ◽  
Donor Kidney ◽  
Sympathetic Nervous ◽  
Donor Kidney Transplantation ◽  
Renal Sympathetic

Increased sympathetic activity is suggested to be part of the pathogenesis in several diseases. Methods to evaluate sympathetic activity and renal nervous denervation procedural success are lacking. Scintigraphy using the norepinephrine analog Iodine-123 Metaiodobenzylguanidine (123I-MIBG) might provide information on renal sympathetic nervous activity. Renal transplantation induces complete denervation of the kidney and as such represents an ideal model to evaluate the renal 123I-MIBG scintigraphy method. The aim of this study was to evaluate whether renal 123I-MIBG scintigraphy can detect changes in renal sympathetic nervous activity following renal transplantation. Renal 123I-MIBG scintigraphy was performed in eleven renal transplant recipients at 1, 3, and 6 months following transplantation and in their respective living donors prior to their kidney donation. Relative uptake as well as washout was obtained. In transplanted patients, the relative 4 h uptake of 123I-MIBG, as measured by the kidney/background ratio, was 2.7 (0.4) (mean (SD)), 2.7 (0.5), and 2.5 (0.4) at 1, 3, and 6 months post-transplantation, respectively, as compared with the 4.0 (0.4) value in the donor kidney before donor nephrectomy (p < 0.01). There was no significant change in washout-rate between pre-transplantation and any of the follow-up time points. Living donor kidney transplantation was at 6 months post transplantation, associated with an almost 40% reduction in the relative 4 h 123I-MIBG uptake of the kidney. Further studies will help to fully establish its implications as a marker of renal innervation or denervation.

Cardiac sympathetic imaging with mIBG in cirrhosis and portal hypertension: relation to autonomic and cardiac function

2012 ◽  
Vol 303 (11) ◽  
pp. G1228-G1235 ◽  
Author(s):  
Søren Møller ◽  
Christian Mortensen ◽  
Flemming Bendtsen ◽  
Lars T. Jensen ◽  
Jens P. Gøtze ◽  
...  
Keyword(s):  
Cardiac Dysfunction ◽  
Nervous Activity ◽  
Alcoholic Cirrhosis ◽  
Washout Rate ◽  
Sympathetic Nervous Activity ◽  
Catecholamine Level ◽  
Mibg Scintigraphy ◽  
Neuronal Function ◽  
Sympathetic Nervous

Autonomic and cardiac dysfunction is frequent in cirrhosis and includes increased sympathetic nervous activity, impaired heart rate variability (HRV), and baroreflex sensitivity (BRS). Quantified 123I-metaiodobenzylguanidine ( mIBG) scintigraphy reflects cardiac noradrenaline uptake, and in patients with cardiac failure it predicts outcome. In this study, we aimed to investigate cardiac sympathetic neuronal function in cirrhosis by mIBG scintigraphy in relation to cardiovascular function. Ten patients with alcoholic cirrhosis and 10 age- and sex-matched healthy controls participated in the study. Heart/mediastinum (H/M) ratios of mIBG uptake were calculated 15 and 230 min after intravenous injection of mIBG. Furthermore, washout rate (WOR) of mIBG was calculated. The patients underwent a liver vein catheterization with determination of splanchnic and systemic hemodynamics and measurement of HRV and BRS. mIBG-scintigraphy revealed significantly increased WOR in patients with cirrhosis compared with controls ( P < 0.005), whereas H/M uptakes were equal in the groups. Forty percent of the patients had reduced uptake of mIBG in the infero-lateral segment of the left ventricle. WOR correlated significantly with central circulation time, an estimate of central hypovolemia ( r = −0.64, P < 0.05) and frequency-corrected QTF interval ( r = 0.71, P = 0.01). Patients with cirrhosis had significantly decreased HRV and BRS correlating with indicators of abnormal cathecholamine uptake by mIBG although the catecholamine level was normal in the patients. In conclusion, in alcoholic cirrhosis, mIBG scintigraphy reveals autonomic dysfunction and impaired myocardial distribution of sympathetic nervous activity. It is associated to indicators of central hypovolemia, QT interval, and decreased HRV and BRS. Measurement of myocardial catecholamine uptake by mIBG may add important information on autonomic and cardiac dysfunction in cirrhosis.

scholarly journals Highs and lows of sympathetic neurocardiovascular transduction: influence of altitude acclimatization and adaptation

2020 ◽  
Vol 319 (6) ◽  
pp. H1240-H1252 ◽  
Author(s):  
Lindsey F Berthelsen ◽  
Graham M. Fraser ◽  
Lydia L. Simpson ◽  
Emily R. Vanden Berg ◽  
Stephen A. Busch ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Altitude ◽  
Sympathetic Activity ◽  
Nervous Activity ◽  
Pressure Control ◽  
Sympathetic Nervous Activity ◽  
Pressure Regulation ◽  
Sympathetic Activation ◽  
Data Set ◽  
Sympathetic Nervous

This study has identified that sympathetically mediated blood pressure regulation is reduced following ascent to high altitude. Additionally, we show that high-altitude Andean natives have reduced blood pressure responsiveness to sympathetic nervous activity (SNA) outflow compared with Nepalese Sherpa. However, basal sympathetic activity is inversely related to the magnitude of SNA-mediated fluctuations in blood pressure regardless of population or condition. These data set a foundation to explore more precise mechanisms of blood pressure control under conditions of persistent sympathetic activation and hypoxia.

Neuropeptide Y as an indicator of successful alterations in sympathetic nervous activity after renal sympathetic denervation

2015 ◽  
Vol 104 (12) ◽  
pp. 1064-1071 ◽  
Author(s):  
Oliver Dörr ◽  
Sebastian Ewen ◽  
Christoph Liebetrau ◽  
Helge Möllmann ◽  
Luise Gaede ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Nervous Activity ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

Direct measurement of renal sympathetic nervous activity in high-fat diet-related hypertensive rats

Life Sciences ◽  
2002 ◽  
Vol 71 (5) ◽  
pp. 537-546 ◽  
Author(s):  
Soh Iwashita ◽  
Mamoru Tanida ◽  
Naohito Terui ◽  
Youichirou Ootsuka ◽  
Miao Shu ◽  
...  
Keyword(s):  
Direct Measurement ◽  
High Fat Diet ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
High Fat ◽  
Hypertensive Rats ◽  
Sympathetic Nervous ◽  
Renal Sympathetic

Sympathetic activity, lipids accumulation, and arterial wall morphology in rabbits at high altitude

1986 ◽  
Vol 250 (3) ◽  
pp. R485-R492 ◽  
Author(s):  
K. Fronek ◽  
N. Alexander
Keyword(s):  
Smooth Muscle ◽  
High Altitude ◽  
Sea Level ◽  
Lipid Accumulation ◽  
Sympathetic Activity ◽  
Arterial Wall ◽  
Sympathetic Innervation ◽  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous

The purpose of this study was to investigate the effect of increased sympathetic nervous activity on arterial wall viability as reflected by its response to elevated plasma lipids. Our previous finding that vascular wall viability was reduced by low sympathetic nervous activity indicated that chronically enhanced sympathetic activity should have the opposite effect. In this study rabbits were divided into two groups, both of which received 1% cholesterol in the diet. One group was born and raised at high altitude to induce chronic activation of sympathetic activity, and the other was raised at sea level. Aorta of high-altitude rabbits exhibited significantly less lipid accumulation than aortas of sea-level rabbits. This difference in lipid accumulation was accompanied by elevated norepinephrine turnover and decreased sensitivity to exogenous norepinephrine of high-altitude rabbit arteries. Vascular smooth muscle cells of high-altitude rabbits demonstrated striated increased relative volume density of mitochondria and decreased nucleocytoplasmic ratio, reflecting lower mitotic rate. These results are suggestive that enhanced chronic activity of vascular sympathetic innervation protects smooth muscle from lipid accumulation and exerts a positive effect on vascular viability.

Sympathetic nervous activity in carriers of MC4R mutations

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
D Heutling ◽  
F Sayk ◽  
C Dodt ◽  
HL Fehm ◽  
A Hinney ◽  
...  
Keyword(s):  
Nervous Activity ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous
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