The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers

2005 ◽  
Vol 45 (2) ◽  
pp. 113-122 ◽  
Author(s):  
S. J. Duthie ◽  
A. McE. Jenkinson ◽  
A. Crozier ◽  
W. Mullen ◽  
L. Pirie ◽  
...  
Keyword(s):  
Heart Disease ◽  
Antioxidant Status ◽  
Cranberry Juice ◽  
Healthy Human ◽  
Human Volunteers

Gastroretentive Floating Capsules of Risedronate Sodium: Development, Optimization, in vitro and in vivo Evaluation in Healthy Human Volunteers

2015 ◽  
Vol 8 (2) ◽  
pp. 2835-2842
Author(s):  
Bhikshapathi D. V. R. N. ◽  
Arun Kumar Jarathi ◽  
Suresh Gande ◽  
Viswaja Medipally ◽  
Ramesh Bomma
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Zero Order ◽  
Wet Granulation ◽  
Capsule Formulation ◽  
In Vivo Evaluation ◽  
Healthy Human ◽  
X Ray ◽  
Human Volunteers

Background and the purpose of the study: Risedronate sodium inhibits osteoclast bone resorption and modulates bone metabolism. Risedronate has a high affinity for hydroxyapatite crystals in bone and is a potent antiresorptive agent. In the present investigation efforts were made to improve the bioavailability of risedronate sodium by increasing the residence time of the drug through sustained-release matrix capsule formulation via gastroretentive mechanism. Capsules were prepared by wet granulation technique. The influence of gel forming agents, amount of risedronate and total weight of capsules on physical properties, in vitro buoyancy, drug release, FTIR, DSC, X-ray studies were investigated. The release mechanisms were explored and explained by applying zero order, first order, Higuchi and Korsmeyer equations. The selected formulations were subjected to stability study at 40 °C/75% RH, 25 °C/60% RH for the period of three months. For all formulations, kinetics of drug release from capsules followed Higuchi’s square root of time kinetic treatment heralding diffusion as predominant mechanism of drug release. Formulation containing 25 mg HPMC K4M and 75 mg HPMC K100 LV (F-8) showed zero order release profile. There was no significant change in the selected formulation, when subjected to accelerated stability conditions over a period of three months. X-ray imaging in six healthy human volunteers revealed a mean gastric retention period of 5.60 ± 0.77 hrs for the selected formulation. Stable, sustained release effervescent floating capsules of risedronate sodium could be prepared by wet granulation technique.  

Synthetic Nanoclay Gels Do Not Cause Skin Irritation in Healthy Human Volunteers

2021 ◽  
Author(s):  
Luciana E. Bostan ◽  
Claire E. Clarkin ◽  
Mohamed Mousa ◽  
Peter R. Worsley ◽  
Daniel L. Bader ◽  
...  
Keyword(s):  
Skin Irritation ◽  
Healthy Human ◽  
Human Volunteers

Some Effects of Nalorphine on the Behaviour of Healthy Human Volunteers

1957 ◽  
Vol 103 (433) ◽  
pp. 850-854 ◽  
Author(s):  
D. A. Cahal
Keyword(s):  
Healthy Human ◽  
Human Volunteers

Some workers have claimed that nalorphine is as potent an analgesic as morphine and does not lead to addiction.

Short‐Term Repeatability of in Vivo Cardiac Intravoxel Incoherent Motion Tensor Imaging in Healthy Human Volunteers

2021 ◽  
Author(s):  
Xiu‐Shi Zhang ◽  
En‐Hui Liu ◽  
Xin‐Yu Wang ◽  
Xin‐Xiang Zhou ◽  
Hong‐Xia Zhang ◽  
...  
Keyword(s):  
Intravoxel Incoherent Motion ◽  
Short Term ◽  
Healthy Human ◽  
Human Volunteers

scholarly journals Enzymatic assay of d-mannose in serum

1997 ◽  
Vol 43 (3) ◽  
pp. 533-538 ◽  
Author(s):  
James R Etchison ◽  
Hudson H Freeze
Keyword(s):  
Bacillus Stearothermophilus ◽  
Anion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Enzymatic Assay ◽  
Enzymatic Reactions ◽  
Reaction Products ◽  
Serum Samples ◽  
Healthy Human ◽  
Human Volunteers ◽  
Chromatography Step

Abstract We describe a new and improved enzymatic assay for determining the concentration of d-mannose in sera. Serum d-glucose is selectively converted to glucose-6 phosphate with the highly specific thermostable glucokinase (EC 2.7.1.2) from Bacillus stearothermophilus. The anionic reaction products and excess substrates are removed by a rapid and simple anion-exchange chromatography step in microcentrifuge spin columns. d-Mannose in the glucose-depleted sample is then assayed spectrophotometrically by using coupled enzymatic reactions. The quantitative elimination of glucose from the serum samples allowed the accurate and reproducible assay of serum mannose in the 0–200 μmol/L range. Recovery of mannose added to serum (5–200 μmol/L) was 94% ± 4.4%. The intraassay CV was 6.7% at 40 μmol/L mannose (n = 5; 39.6 ± 1.6 μmol/L) and 4.4% at 80 μmol/L (n = 11; 75.0 ± 1.8 μmol/L); the interassay CV at these concentrations was 12.2% (n = 7; 36.9 ± 2.1 μmol/L) and 9.8% (n = 7; 74.2 ± 2.7 μmol/L), respectively. Sera from 11 healthy human volunteers contained an average of 54.1 ± 11.9 μmol/L mannose (range 36–81 μmol/L).

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