Effect of sinapic acid on hair growth promoting in human hair follicle dermal papilla cells via Akt activation

2017 ◽  
Vol 309 (5) ◽  
pp. 381-388 ◽  
Author(s):  
Hyunju Woo ◽  
Seungjun Lee ◽  
Seungbeom Kim ◽  
Deokhoon Park ◽  
Eunsun Jung
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Hair Growth ◽  
Sinapic Acid ◽  
Dermal Papilla ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells ◽  
Akt Activation ◽  
Growth Promoting

scholarly journals Hair Growth Promoting Effect of Hottuynia cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells

2019 ◽  
Vol 42 (10) ◽  
pp. 1665-1673 ◽  
Author(s):  
Jaeyoon Kim ◽  
Jae young Shin ◽  
Yun-Ho Choi ◽  
Mi Jang ◽  
You Jin Nam ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Human Hair Follicle ◽  
Promoting Effect ◽  
Dermal Papilla Cells ◽  
Growth Promoting

scholarly journals Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9867
Author(s):  
Ke Sha ◽  
Mengting Chen ◽  
Fangfen Liu ◽  
San Xu ◽  
Ben Wang ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Hair Follicle ◽  
Human Hair ◽  
Hair Growth ◽  
Dermal Papilla ◽  
Follicle Growth ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells ◽  
Platelet Factor ◽  
Hair Follicle Growth

Platelet-rich plasma (PRP) has been reported recently as a potential therapeutic approach for alopecia, such as androgenetic alopecia, but the exact mechanisms and effects of specific components of this recipe remain largely unknown. In this study, we identified that platelet factor 4 (PF4), a component of PRP, significantly suppressed human hair follicle growth and restrained the proliferation of human dermal papilla cells (hDPCs). Furthermore, our results showed that PF4 upregulated androgen receptor (AR) in human dermal papilla cells in vitro and via hair follicle organ culture. Among the hair growth-promoting and DP-signature genes investigated, PF4 decreased the expression of Wnt5a, Wnt10b, LEF1, HEY1 and IGF-1, and increased DKK1 expression, but did not affect BMP2 and BMP4 expression. Collectively, Our data demonstrate that PF4 suppresses human hair follicle growth possibly via upregulating androgen receptor signaling and modulating hair growth-associated genes, which provides thought-provoking insights into the application and optimization of PRP in treating hair loss.

scholarly journals Reprogramming of Human Hair Follicle Dermal Papilla Cells into Induced Pluripotent Stem Cells

2012 ◽  
Vol 132 (6) ◽  
pp. 1725-1727 ◽  
Author(s):  
Claire A. Higgins ◽  
Munenari Itoh ◽  
Keita Inoue ◽  
Gavin D. Richardson ◽  
Colin A.B. Jahoda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Hair Follicle ◽  
Pluripotent Stem Cells ◽  
Human Hair ◽  
Dermal Papilla ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells ◽  
Induced Pluripotent

Preservation of a specialized phenotype of dermal papilla cells of a human hair follicle under cultivation conditions

2017 ◽  
Vol 44 (4) ◽  
pp. 363-371
Author(s):  
E. P. Kalabusheva ◽  
E. S. Chermnykh ◽  
V. V. Terskikh ◽  
E. A. Vorotelyak
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Dermal Papilla ◽  
Cultivation Conditions ◽  
Human Hair Follicle ◽  
Dermal Papilla Cells
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