human hair follicle
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Life ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 117
Author(s):  
José María Llamas-Molina ◽  
Alejandro Carrero-Castaño ◽  
Ricardo Ruiz-Villaverde ◽  
Antonio Campos

Androgenetic alopecia (AGA) is an androgen-dependent process and represents the most frequent non-scarring alopecia. Treatments for AGA do not always achieve a satisfactory result for the patient, and sometimes cause side effects that lead to discontinuation of treatment. AGA therapeutics currently includes topical and oral drugs, as well as follicular unit micro-transplantation techniques. Tissue engineering (TE) is postulated as one of the possible future solutions to the problem and aims to develop fully functional hair follicles that maintain their cyclic rhythm in a physiological manner. However, despite its great potential, reconstitution of fully functional hair follicles is still a challenge to overcome and the knowledge gained of the key processes in hair follicle morphogenesis and biology has not yet been translated into effective replacement therapies in clinical practice. To achieve this, it is necessary to research and develop new approaches, techniques and biomaterials. In this review, present and emerging hair follicle bioengineering strategies are evaluated. The current problems of these bioengineering techniques are discussed, as well as the advantages and disadvantages, and the future prospects for the field of TE and successful hair follicle regeneration.



2021 ◽  
pp. 112887
Author(s):  
Ramya Lakshmi Rajendran ◽  
Prakash Gangadaran ◽  
Mi Hee Kwack ◽  
Ji Min Oh ◽  
Chae Moon Hong ◽  
...  


2021 ◽  
Vol 43 (3) ◽  
pp. 1361-1373
Author(s):  
Jae Young Shin ◽  
Jaeyoon Kim ◽  
Yun-Ho Choi ◽  
Nae-Gyu Kang ◽  
Sanghwa Lee

Dexpanthenol (D-panthenol) is a precursor of vitamin B5 (pantothenic acid) and is widely used for dietary supplements and topical applications. D-panthenol has long been used in hair care products for the purpose of anti-hair loss, its effects and the underlying mechanisms, however, were barely reported. In this study, the effects of D-panthenol on human hair follicle cells, including dermal papilla cells (hDPCs) and outer root sheath cells (hORSCs), were investigated. D-panthenol enhanced the cell viability, increasing the cellular proliferation marker Ki67 in cultured hDPCs. The markers for apoptosis (Caspase3/9) and cell senescence (p21/p16), reported to be expressed in aged or resting phase follicles, were significantly reduced by D-panthenol. Anagen-inducing factors (ALP; β-catenin; versican), which trigger or elongate the anagen phase, were stimulated by D-panthenol. On the other hand, D-panthenol reduced TGF-β1 expressions in both mRNA and protein levels. The expression of VEGF, which is important for peripheral blood vessel activation; was up-regulated by D-panthenol treatment. In cultured hORSCs, cell proliferation and viability were enhanced, while the mRNA expression of cell senescence markers (p21/p16) was significantly down-regulated. The expressions of both VEGF and its receptor (VEGFR) were up-regulated by D-panthenol. In conclusion, our data suggest that the hair growth stimulating activity of D-panthenol was exerted by increasing the cell viability, suppressing the apoptotic markers, and elongating the anagen phase in hair follicles.



2021 ◽  
Vol 85 (3) ◽  
pp. AB68
Author(s):  
Ana Coutinho ◽  
Fernanda Chaves Beltrão ◽  
Fabio Sanches ◽  
Valerie Mengeaud ◽  
Camille Mas ◽  
...  


2021 ◽  
Vol 69 (5) ◽  
pp. 464-471
Author(s):  
Toshio Morikawa ◽  
Yoshiaki Manse ◽  
Fenglin Luo ◽  
Haruko Fukui ◽  
Yamato Inoue ◽  
...  




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