DNA Commission of the International Society of Forensic Genetics: recommendations on forensic analysis using Y-chromosome STRs

2001 ◽  
Vol 114 (6) ◽  
pp. 305-309 ◽  
Author(s):  
P. Gill ◽  
C. Brenner ◽  
B. Brinkmann ◽  
B. Budowle ◽  
A. Carracedo ◽  
...  
Keyword(s):  
Y Chromosome ◽  
International Society ◽  
Forensic Genetics ◽  
Forensic Analysis

DNA Commission of the International Society of Forensic Genetics: recommendations on forensic analysis using Y-chromosome STRs

2001 ◽  
Vol 124 (1) ◽  
pp. 5-10 ◽  
Author(s):  
P. Gill ◽  
C. Brenner ◽  
B. Brinkmann ◽  
B. Budowle ◽  
A. Carracedo ◽  
...  
Keyword(s):  
Y Chromosome ◽  
International Society ◽  
Forensic Genetics ◽  
Forensic Analysis

scholarly journals Recommendations of the Polish Speaking Working Group of the International Society for Forensic Genetics on forensic Y chromosome typing

2020 ◽  
Vol 70 (1) ◽  
pp. 1-18
Author(s):  
Krzysztof Rębała ◽  
Wojciech Branicki ◽  
Ryszard Pawłowski ◽  
Magdalena Spólnicka ◽  
Tomasz Kupiec ◽  
...  
Keyword(s):  
Y Chromosome ◽  
International Society ◽  
Working Group ◽  
Forensic Genetics

scholarly journals Sequence Read Depth Analysis of a Monophyletic Cluster of Y Chromosomes Characterized by Structural Rearrangements in the AZFc Region Resulting in DYS448 Deletion and DYF387S1 Duplication

2021 ◽  
Vol 12 ◽  
Author(s):  
Francesco Ravasini ◽  
Eugenia D’Atanasio ◽  
Maria Bonito ◽  
Biancamaria Bonucci ◽  
Chiara Della Rocca ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Tandem Repeats ◽  
Forensic Genetics ◽  
Read Depth ◽  
Duplication Event ◽  
Forensic Analysis ◽  
Deletion Event ◽  
Monophyletic Cluster ◽  
Depth Analysis ◽  
Factor C

The azoospermia factor c region (AZFc), located in the long arm of the human Y chromosome, is frequently involved in chromosome rearrangements, mainly due to non-allelic homologous recombination events that occur between the nearly identical sequences (amplicon) that comprises it. These rearrangements may have major phenotypic effects like spermatogenic failure or other pathologies linked to male infertility. Moreover, they may also be relevant in forensic genetics, since some of the Y chromosome short tandem repeats (Y-STRs) commonly used in forensic analysis are located in amplicons or in inter-amplicon sequences of the AZFc. In a previous study, we identified four phylogenetically related samples with a null allele at DYS448 and a tetrallelic pattern at DYF387S1, two Y-STRs located in the AZFc. Through NGS read depth analysis, we found that the unusual Y-STR pattern may be due to a 1.6 Mb deletion arising concurrently or after a 3.5 Mb duplication event. The observed large genomic rearrangement results in copy number reduction for the RBMY gene family as well as duplication of other AZFc genes. Based on the diversity of 16 additional Y-STRs, we estimated that the duplication/deletion event occurred at least twenty generations ago, suggesting that it has not been affected by negative selection.

scholarly journals DNA commission of the International Society of Forensic Genetics (ISFG): Recommendations on the interpretation of Y-STR results in forensic analysis

2020 ◽  
Vol 48 ◽  
pp. 102308 ◽  
Author(s):  
Lutz Roewer ◽  
Mikkel Meyer Andersen ◽  
Jack Ballantyne ◽  
John M. Butler ◽  
Amke Caliebe ◽  
...  
Keyword(s):  
International Society ◽  
Forensic Genetics ◽  
Forensic Analysis
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