Differences in overshoot of blood pressure after head-up tilt in two groups with chronic autonomic failure: pure autonomic failure and multiple system atrophy

2005 ◽  
Vol 252 (1) ◽  
pp. 72-77 ◽  
Author(s):  
Masato Asahina ◽  
Tim M. Young ◽  
Katharine Bleasdale-Barr ◽  
Christopher J. Mathias
Keyword(s):  
Blood Pressure ◽  
Multiple System Atrophy ◽  
Autonomic Failure ◽  
Pure Autonomic Failure ◽  
Head Up Tilt

Differential responses in superior mesenteric artery blood flow may explain the variant pressor responses to clonidine in two groups with sympathetic denervation

1992 ◽  
Vol 83 (1) ◽  
pp. 59-64 ◽  
Author(s):  
T. N. Thomaides ◽  
K. Ray Chaudhuri ◽  
S. Maule ◽  
C. J. Mathias
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Multiple System Atrophy ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Autonomic Failure ◽  
Pure Autonomic Failure ◽  
Artery Blood Flow ◽  
Control Subjects ◽  
Mesenteric Artery Blood Flow

1. Measurement of superior mesenteric artery blood flow along with systemic and regional haemodynamic changes in blood pressure, heart rate, cardiac index, forearm blood flow, digital skin blood flow and index finger temperature were made before and after administration of clonidine (2 μg/kg body weight intravenously) in 10 patients with multiple-system atrophy, 10 patients with pure autonomic failure and 15 age-matched healthy control subjects. 2. After clonidine, blood pressure fell in patients with multiple-system atrophy and control subjects but not in patients with pure autonomic failure. 3. Resting superior mesenteric artery blood flow was similar in patients with multiple-system atrophy and control subjects, but was higher in patients with pure autonomic failure. The fall in blood pressure after clonidine was accompanied by active dilatation of the superior mesenteric artery in patients with multiple-system atrophy and control subjects. This did not occur in patients with pure autonomic failure. 4. After clonidine, there was a fall in cardiac index in patients with multiple-system atrophy. 5. After clonidine, changes in other haemodynamic parameters were not significant in any group, except for a fall in forearm blood flow and a rise in index finger temperature in control subjects. 6. We conclude that after clonidine there are differential superior mesenteric artery blood flow responses in the two groups with autonomic failure (multiple-system atrophy and pure autonomic failure). These may relate to differences in the site of the sympathetic lesion, which is considered to be mainly central in multiple-system atrophy but peripheral in pure autonomic failure. The blood pressure responses to clonidine in the two groups may be largely dependent on changes in superior mesenteric artery blood flow.

scholarly journals Pulsed Wave Doppler Ultrasound Is Useful to Assess Vasomotor Response in Patients with Multiple System Atrophy and Well Correlated with Tilt Table Study

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Ke-Vin Chang ◽  
Wen-Shiang Chen ◽  
Ruey-Meei Wu ◽  
Ssu-Yuan Chen ◽  
Hsiu-Yu Shen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Correlation Analysis ◽  
Multiple System Atrophy ◽  
Cardiovascular Response ◽  
Vasomotor Response ◽  
Tilt Table ◽  
Hemodynamic Variables ◽  
Pulsed Wave Doppler ◽  
Head Up Tilt

The study aim was to assess sympathetic vasomotor response (SVR) by using pulsed wave Doppler (PWD) ultrasound in patients with multiple system atrophy (MSA) and correlate with the tilt table study. We recruited 18 male patients and 10 healthy men as controls. The SVR of the radial artery was evaluated by PWD, using inspiratory cough as a provocative maneuver. The response to head-up tilt was studied by a tilt table with simultaneous heart rate and blood pressure recording. The hemodynamic variables were compared between groups, and were examined by correlation analysis. Regarding SVR, MSA patients exhibited a prolonged latency and less heart rate acceleration following inspiratory cough. Compared with the tilt table test, the elevation of heart rate upon SVR was positively correlated to the increase of heart rate after head-up tilt. The correlation analysis indicated that the magnitude of blood pressure drop from supine to upright was positively associated with the SVR latency but negatively correlated with the heart rate changes upon SVR. The present study demonstrated that blunted heart rate response might explain MSA's vulnerability to postural challenge. PWD may be used to predict cardiovascular response to orthostatic stress upon head-up tilt in MSA patients.

Differences in skin sympathetic involvements between two chronic autonomic disorders: Multiple system atrophy and pure autonomic failure

2009 ◽  
Vol 15 (5) ◽  
pp. 347-350 ◽  
Author(s):  
Masato Asahina ◽  
Yuichi Akaogi ◽  
Yoshitaka Yamanaka ◽  
Yu Koyama ◽  
Takamichi Hattori
Keyword(s):  
Multiple System Atrophy ◽  
Autonomic Failure ◽  
Pure Autonomic Failure ◽  
Autonomic Disorders

The cardiovascular effects of metoclopramide in multiple system atrophy and pure autonomic failure

2001 ◽  
Vol 11 (3) ◽  
pp. 163-168 ◽  
Author(s):  
Fabiola Magnifico ◽  
Giulia Pierangeli ◽  
Giorgio Barletta ◽  
Carmen Candela ◽  
Giuseppe Bonavina ◽  
...  
Keyword(s):  
Multiple System Atrophy ◽  
Autonomic Failure ◽  
Cardiovascular Effects ◽  
Pure Autonomic Failure

Sleep patterns and blood pressure variability in patients with pure autonomic failure

1991 ◽  
Vol 1 (4) ◽  
pp. 309-315 ◽  
Author(s):  
J. H. M. Tulen ◽  
A. J. Man in 't Veld ◽  
H. G. van Steenis ◽  
K. Mechelse
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Autonomic Failure ◽  
Pure Autonomic Failure ◽  
Sleep Patterns
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