scholarly journals Very late-onset neuromyelitis optica spectrum disorder beyond the age of 75

2015 ◽  
Vol 262 (5) ◽  
pp. 1379-1384 ◽  
Author(s):  
Markus Krumbholz ◽  
Ulrich Hofstadt-van Oy ◽  
Klemens Angstwurm ◽  
Ingo Kleiter ◽  
Sven Jarius ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Late Onset ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder

AQP4-IgG-positive neuromyelitis optica spectrum disorder with late onset in Mexico.

2020 ◽  
Vol 43 ◽  
pp. 102221 ◽  
Author(s):  
Guillermo Delgado-García ◽  
Emmanuel Antonio-Luna ◽  
Diego López-Mena ◽  
Verónica Rivas-Alonso ◽  
José Flores-Rivera ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Late Onset ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder

Clinical characteristics of very late-onset neuromyelitis optica spectrum disorder

2020 ◽  
Vol 46 ◽  
pp. 102515
Author(s):  
L.J. Cai ◽  
Q. Zhang ◽  
Y. Zhang ◽  
H.X. Chen ◽  
Z.Y. Shi ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Clinical Characteristics ◽  
Late Onset ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder

A treatable cause of myelopathy and vision loss mimicking neuromyelitis optica spectrum disorder: late-onset biotinidase deficiency

2017 ◽  
Vol 32 (3) ◽  
pp. 675-678 ◽  
Author(s):  
Sanem Yilmaz ◽  
Mine Serin ◽  
Ebru Canda ◽  
Cenk Eraslan ◽  
Hande Tekin ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Vision Loss ◽  
Late Onset ◽  
Biotinidase Deficiency ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder

scholarly journals Late-onset neuromyelitis optica spectrum disorder

2019 ◽  
Vol 6 (6) ◽  
pp. e607 ◽  
Author(s):  
Maria Sepulveda ◽  
Guillermo Delgado-García ◽  
Yolanda Blanco ◽  
Nuria Sola-Valls ◽  
Elena H. Martinez-Lapiscina ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Clinical Presentation ◽  
Late Onset ◽  
Age At Onset ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Igg Antibodies ◽  
Retrospective Multicenter Study ◽  
Demographic Features

ObjectiveTo describe the clinical features of late-onset (≥50 years) neuromyelitis optica spectrum disorder (LO-NMOSD), to compare the outcome with that of early-onset (EO-NMOSD), and to identify predictors of disability.MethodsA retrospective, multicenter study of 238 patients with NMOSD identified by the 2015 criteria. Clinical and immunologic features of patients with LO-NMOSD were compared with those with EO-NMOSD. All patients were evaluated for aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) antibodies.ResultsSixty-nine (29%) patients had LO-NMOSD. Demographic features, initial disease presentation, annualized relapse rate, and frequency of AQP4-IgG and MOG-IgG did not differ between patients with LO-NMOSD and EO-NMOSD. Among patients with AQP4-IgG or double seronegativity, those with LO-NMOSD had a higher risk to require a cane to walk (hazard ratio [HR], 2.10, 95% CI 1.3–3.54, p = 0.003 for AQP4-IgG, and HR, 13.0, 95% CI 2.8–59.7, p = 0.001, for double seronegative). No differences in outcome were observed between patients with MOG-IgG and LO-NMOSD or EO-NMOSD. Older age at onset (for every 10-year increase, HR 1.63, 95% CI 1.35–1.92 p < 0.001) in NMOSD, and higher disability after the first attack (HR 1.68, 95% CI 1.32–2.14, p < 0.001), and double seronegativity (HR 3.74, 95% CI 1.03–13.6, p = 0.045) in LO-NMOSD were the main independent predictors of worse outcome.ConclusionsPatients with LO-NMOSD have similar clinical presentation but worse outcome than EO-NMOSD when they are double seronegative or AQP4-IgG positive. Serostatus and residual disability after first attack are the main predictors of LO-NMOSD outcome.

scholarly journals Two Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80

2020 ◽  
Vol 12 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Shunya Fujiwara ◽  
Yasuhiro Manabe ◽  
Ryuta Morihara ◽  
Taijun Yunoki ◽  
Syoichiro Kono ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Clinical Course ◽  
Late Onset ◽  
Transverse Myelitis ◽  
Spectrum Disorder ◽  
High Dose ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Initial Manifestation ◽  
High Dose Methylprednisolone ◽  
Aqp4 Antibody

We report two cases of very-late-onset neuromyelitis optica spectrum disorder (NMOSD) in patients over the age of 80 with transverse myelopathy as the initial manifestation. In both cases, the patients presented with paraplegia and sensory, bladder, and rectal disturbances. Thoracic magnetic resonance imaging showed longitudinal high-intensity signals on a T2-weighted image. The patients received high-dose methylprednisolone. Their serum was positive for anti-AQP4 antibody (cell-based assay) during the clinical course. They were diagnosed with NMOSD and treated with immunoadsorption, plasmapheresis, and followed up with daily prednisolone. Very-late-onset NMOSD in patients over the age of 80 has only rarely been reported. The present cases suggest that NMOSD should be considered for elderly patients presenting with transverse myelitis. Early diagnosis and treatment are important.

Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea

2017 ◽  
Vol 23 (13) ◽  
pp. 1748-1756 ◽  
Author(s):  
Jin Myoung Seok ◽  
Hye-Jin Cho ◽  
Suk-Won Ahn ◽  
Eun Bin Cho ◽  
Min Su Park ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Clinical Laboratory ◽  
Age Of Onset ◽  
Late Onset ◽  
Brain Mri ◽  
Age At Onset ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Tertiary Hospitals ◽  
Characteristic Features

Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (⩾50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (<50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated. Results: Among a total of 147 patients (125 female; age of onset, 39.4 ± 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LO-NMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up ( r = 0.246, p = 0.003). Conclusion: Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.

scholarly journals Very-Late-Onset Neuromyelitis Optica Spectrum Disorder in a Patient with Breast Cancer and Parkinson Disease

2021 ◽  
pp. 53-58
Author(s):  
Yasutaka Tajima ◽  
Yukako Sone ◽  
Hiroaki Yaguchi ◽  
Yasunori Mito
Keyword(s):  
Spinal Cord ◽  
Parkinson Disease ◽  
Steroid Therapy ◽  
Neuromyelitis Optica ◽  
Late Onset ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Consciousness Disturbance ◽  
Leg Weakness ◽  
The Right

Anti-aquaporin-4 (anti-AQP-4) antibody-positive neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disorder resulting in severe, recurrent optic neuritis, transverse myelitis, brain stem syndrome, and other types of neurological involvement. Its median age of onset has been reported to be around 40 years. We report herein a case of very-late-onset NMOSD (76 years of age) and try to promote its awareness as a type of neurological deterioration in elder patients. A 76-year-old woman suffering from Parkinson disease was admitted to our hospital because of consciousness disturbance. Cranial magnetic resonance imaging revealed the presence of fluid-attenuated inversion recovery high-signal-intensity lesions in the right peri- and intralateral ventricle. Part of this lesion and the meninges showed gadolinium enhancement. Physical examination revealed the presence of a tumor in the right breast, which was later diagnosed as invasive ductal carcinoma. In addition, laboratory examinations led to the detection of anti-AQP-4 antibodies in her serum; consequently, the patient was diagnosed as having NMOSD. She received initial pulsed steroid therapy, followed by right mastectomy. Although the patient’s consciousness improved significantly, she developed abrupt-onset bilateral leg weakness and multiple longitudinal spinal cord lesions. Additional steroid therapy ameliorated the patient’s leg weakness and reduced the swelling of the spinal cord.

Late-Onset Neuromyelitis Optica Spectrum Disorder Presenting With Area Postrema Syndrome

2020 ◽  
Vol 47 (3) ◽  
pp. 422-424
Author(s):  
Alex Kennedy ◽  
Benjamin Beland ◽  
Tyson Brust ◽  
Wei-Qiao Liu ◽  
Carlos R. Camara-Lemarroy
Keyword(s):  
Neuromyelitis Optica ◽  
Late Onset ◽  
Area Postrema ◽  
Spectrum Disorder ◽  
Neuromyelitis Optica Spectrum Disorder
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