Cardiorespiratory responses during three repeated incremental exercise tests in sickle cell trait carriers

2007 ◽  
Vol 102 (2) ◽  
pp. 181-187 ◽  
Author(s):  
Laurent Marlin ◽  
Philippe Connes ◽  
Sophie Antoine-Jonville ◽  
Julien Tripette ◽  
Mona Montout-Hedreville ◽  
...  
2006 ◽  
Vol 27 (6) ◽  
pp. 436-443 ◽  
Author(s):  
F. Sara ◽  
M.-D. Hardy-Dessources ◽  
L. Marlin ◽  
P. Connes ◽  
O. Hue

1995 ◽  
Vol 16 (07) ◽  
pp. 428-434 ◽  
Author(s):  
H. Freund ◽  
J. Lonsdorfer ◽  
S. Oyono-Enguéllé ◽  
A. Lonsdorfe ◽  
C. Dah ◽  
...  

1998 ◽  
Vol 30 (5) ◽  
pp. 649-654 ◽  
Author(s):  
ALPHONSE BILE ◽  
DANIEL LE GALLAIS ◽  
BEATRICE MERCIER ◽  
PATRICIA MARTINEZ ◽  
SAID AHMAIDI ◽  
...  

2005 ◽  
Vol 13 (3) ◽  
pp. 254-265 ◽  
Author(s):  
Fabien Deruelle ◽  
Cédric Nourry ◽  
Patrick Mucci ◽  
Frédéric Bart ◽  
Jean-Marie Grosbois ◽  
...  

This study aimed to analyze the impact of step-duration protocols, 1-min vs. 3-min, on cardiorespiratory responses to exercise, whatever the aerobic-fitness level of sedentary (65.5 ± 2.3 years,n= 8) or highly fit (63.1 ± 3.2 years,n= 19) participants. Heart rate and VO2at the first and second ventilatory thresholds (VT1, VT2) and maximal exercise were not significantly different between the two protocols. In master athletes, the 3-min protocol elicited significantly lower ventilation at VT2and maximal exercise (p< .01). In the latter, breathlessness was also lower at maximal exercise (p< .05) than in sedentary participants. In trained or sedentary older adults, VT1, VT2, and VO2maxwere not influenced by stage duration. According to the lower breathlessness and ventilation, however, the 3-min step protocol could be more appropriate in master athletes. In untrained participants, because the cardiorespiratory responses were similar with the two incremental exercise tests, either of them could be used.


1977 ◽  
Vol 137 (3) ◽  
pp. 281a-281
Author(s):  
P. E. Mickelson

2020 ◽  
pp. 1-2
Author(s):  
Michael Alperovich ◽  
Eric Park ◽  
Michael Alperovich ◽  
Omar Allam ◽  
Paul Abraham

Although sickle cell disease has long been viewed as a contraindication to free flap transfer, little data exist evaluating complications of microsurgical procedures in the sickle cell trait patient. Reported is the case of a 55-year-old woman with sickle cell trait who underwent a deep inferior epigastric perforator (DIEP) microvascular free flap following mastectomy. The flap developed signs of venous congestion on postoperative day two but was found to have patent arterial and venous anastomoses upon exploration in the operating room. On near-infrared indocyanine green angiography, poor vascular flow was noted despite patent anastomoses and strong cutaneous arterial Doppler signals. Intrinsic microvascular compromise or sickling remains a risk in the sickle cell trait population as it does for the sickle cell disease population. Just like in sickle cell disease patients, special care should be taken to optimize anticoagulation and minimize ischemia-induced sickling for patients with sickle cell trait undergoing microsurgery.


2021 ◽  
pp. 100047
Author(s):  
Álvaro Alejandre-de-Oña ◽  
Jaime Alonso-Muñoz ◽  
Pablo Demelo-Rodríguez ◽  
Jorge del-Toro-Cervera ◽  
Francisco Galeano-Valle

Blood ◽  
1963 ◽  
Vol 22 (3) ◽  
pp. 334-341 ◽  
Author(s):  
RICHARD D. LEVERE ◽  
HERBERT C. LICHTMAN ◽  
Joan Levine

Abstract The relative rates of incorporation of Fe59 into heterogenic hemoglobins was studied in four patients with sickle cell trait. Three of the patients were free of superimposed disease, while one had active pulmonary tuberculosis. In all subjects there was a significantly greater incorporation of radioiron, per milligram of hemoglobin, into hemoglobin S than into hemoglobin A. The data indicate that in sickle cell trait the rates of synthesis of the heterogenic hemoglobins are not proportional to their circulating concentrations. Two interpretations appear possible. Since the size of the intra-marrow pool of hemoglobin S was not known, it is possible that there exists a smaller preformed pool of the abnormal hemoglobin, with the isotope making its appearance first in hemoglobin S. However, it is also possible that hemoglobin S is synthesized at a rate which is greater than that reflected by its circulating concentration. This implies that the relative concentrations of hemoglobin S and hemoglobin A vary from erythrocyte to erythrocyte, and that those cells with the greatest proportion of hemoglobin S are selectively destroyed.


1975 ◽  
Vol 250 (22) ◽  
pp. 8630-8634 ◽  
Author(s):  
JR Shaeffer ◽  
MA Longley ◽  
J DeSimone ◽  
LJ Kleve

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