Myoepithelial cells in solid variant of intraductal papillary carcinoma of the breast: a potential diagnostic pitfall and a proposal of an immunohistochemical panel in the differential diagnosis with intraductal papilloma with usual ductal hyperplasia

2007 ◽  
Vol 450 (5) ◽  
pp. 539-547 ◽  
Author(s):  
Suzuko Moritani ◽  
Shu Ichihara ◽  
Ryoji Kushima ◽  
Hidetoshi Okabe ◽  
Masamichi Bamba ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Papillary Carcinoma ◽  
Myoepithelial Cells ◽  
Intraductal Papilloma ◽  
Carcinoma Of The Breast ◽  
Diagnostic Pitfall ◽  
Usual Ductal Hyperplasia ◽  
Ductal Hyperplasia

scholarly journals Use of immunohistochemical analysis of CK5/6, CK14, and CK34betaE12 in the differential diagnosis of solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia of the breast

2018 ◽  
Vol 6 ◽  
pp. 205031211881154 ◽  
Author(s):  
Ichiro Maeda ◽  
Shinya Tajima ◽  
Yoshihide Kanemaki ◽  
Koichiro Tsugawa ◽  
Masayuki Takagi
Keyword(s):  
Differential Diagnosis ◽  
Papillary Carcinoma ◽  
Carcinoma In Situ ◽  
Immunohistochemical Staining ◽  
Immunohistochemical Analysis ◽  
Intraductal Papilloma ◽  
Solid Papillary Carcinoma ◽  
Usual Ductal Hyperplasia ◽  
Ductal Hyperplasia

Objectives: The aim of this study was to use immunohistochemistry to differentiate solid papillary carcinoma in situ from intraductal papilloma with usual ductal hyperplasia (IPUDH). Three types of high-molecular-weight cytokeratins (CKs) – CK5/6, CK14, and CK34betaE12 – were targeted. Methods: We studied 17 patients with solid papillary carcinoma in situ and 18 patients with IPUDH diagnosed by at least two pathologists. Immunohistochemical analyses used antibodies to CK5/6, CK14, and CK34betaE12 to make the differential diagnosis of solid papillary carcinoma in situ versus IPUDH. Immunohistochemical staining was scored as 0–5 using Allred score. Results: Immunohistochemistry with CK5/6 and CK14 antibodies produced scores of 0–3 in all patients with solid papillary carcinoma in situ and 2–5 in all patients with IPUDH. Immunohistochemical staining with CK34betaE12 antibody produced scores of 1–3 in all patients with solid papillary carcinoma and 3–5 in all patients with IPUDH. In tissues from patients with IPUDH, significantly more cells were stained with CK34betaE12 than CK5/6 ( p < 0.05) or CK14 ( p < 0.05). Conclusion: The immunoreactivity of CK5/6, CK14, and CK34betaE12 antibodies was useful to differentiate solid papillary carcinoma in situ from IPUDH. CK34betaE12 is especially useful for distinguishing solid papillary carcinoma from IPUDH.

scholarly journals Intracystic Papillary Carcinoma of the Breast: Report of Three Cases and Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Yassir Ait Benkaddour ◽  
Sawsane El Hasnaoui ◽  
Karima Fichtali ◽  
Bouchra Fakhir ◽  
Hicham Jalal ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Literature Review ◽  
Papillary Carcinoma ◽  
Immunohistochemical Study ◽  
Nipple Discharge ◽  
Conservative Surgery ◽  
Myoepithelial Cells ◽  
Immunohistochemical Examination ◽  
Carcinoma Of The Breast ◽  
Intracystic Papillary Carcinoma

Intracystic papillary carcinoma is a rare malignant tumor of the breast. It occurs communally in postmenopausal women. Clinically it can be asymptomatic or manifested by a breast mass or a nipple discharge. On imaging intracystic papillary carcinoma has usually benign features. Pathologic diagnosis can be difficult at classical histological examination and identification of myoepithelial cells layer by immunohistochemical study can be useful. In the majority of cases of pure intracystic papillary carcinoma, conservative management is possible. Adjuvant therapy is still controversial and prognosis is excellent. We report three cases of intracystic papillary carcinoma diagnosed on immunohistochemical examination and managed with conservative surgery.

scholarly journals Intracystic Papillary Carcinoma of the Breast in a Male Patient: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Sadık Muallaoglu ◽  
Ersin Özdemir ◽  
Lale Kutluay
Keyword(s):  
Breast Cancer ◽  
Papillary Carcinoma ◽  
Male Patient ◽  
Immunohistochemical Study ◽  
Rare Condition ◽  
Myoepithelial Cells ◽  
Breast Cancers ◽  
Breast Carcinomas ◽  
Carcinoma Of The Breast ◽  
Intracystic Papillary Carcinoma

Breast carcinoma is an uncommon neoplastic condition among man, accounting for not more than 1% of all breast cancers. Intracystic papillary carcinoma in man is an extremely rare condition and represents only 5–7,5% of all male breast carcinomas. Clinical and radiological manifestations of intracystic papillary carcinomas are not specific. Pathologic diagnosis can be difficult at classical histological examination and identification of myoepithelial cells layer by immunohistochemical study can be useful. Adjuvant therapy is still controversial and prognosis is excellent. We report a case of this rare histological type of breast cancer in 48-year-old male patient and review the literature.

Molecular Analysis of Encapsulated Papillary Carcinoma of the Breast with and without Invasion

2021 ◽  
Author(s):  
Christopher J. Schwartz ◽  
Amir Momeni Boroujeni ◽  
Alireza Khodadai-Jamayran ◽  
Adriana Heguy ◽  
Matija Snuderl ◽  
...  
Keyword(s):  
Papillary Carcinoma ◽  
Molecular Analysis ◽  
Carcinoma Of The Breast

scholarly journals Solid papillary carcinoma of the breast

2022 ◽  
Vol 12 ◽  
pp. e2021352
Author(s):  
Toyaja Jadhav ◽  
Shashi Shekhar Prasad ◽  
Bhupesh Guleria ◽  
Manvir Singh Tevatia ◽  
Prerna Guleria
Keyword(s):  
Papillary Carcinoma ◽  
Carcinoma Of The Breast ◽  
Solid Papillary Carcinoma
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