D-type cyclins in superficial and muscle-invasive bladder urothelial carcinoma: correlation with clinicopathological data and prognostic significance

2010 ◽  
Vol 136 (10) ◽  
pp. 1563-1571 ◽  
Author(s):  
Georgia Levidou ◽  
Angelica A. Saetta ◽  
Maria Karlou ◽  
Irene Thymara ◽  
Harris Pratsinis ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Significance ◽  
Bladder Urothelial Carcinoma ◽  
Muscle Invasive

Expression and prognostic significance of pyruvate dehydrogenase kinase 1 in bladder urothelial carcinoma

2020 ◽  
Vol 477 (5) ◽  
pp. 637-649
Author(s):  
Jinfeng Zhu ◽  
Guihua Zheng ◽  
Haifei Xu ◽  
Xiaoxia Jin ◽  
Ting Tang ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Pyruvate Dehydrogenase ◽  
Prognostic Significance ◽  
Pyruvate Dehydrogenase Kinase ◽  
Bladder Urothelial Carcinoma ◽  
Pyruvate Dehydrogenase Kinase 1

S109 Prognostic significance of nestin expression in pT1 high-grade bladder urothelial carcinoma patients treated with BCG

2013 ◽  
Vol 12 (4) ◽  
pp. e1217, S109a-e1217, S109d
Author(s):  
V. Şen ◽  
O. Bozkurt ◽  
Ö. Demir ◽  
B. Tuna ◽  
K. Yörükoğlu ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Prognostic Significance ◽  
High Grade ◽  
Nestin Expression ◽  
Bladder Urothelial Carcinoma

Prognostic significance of PIK3CA mutation in patients with muscle-invasive urothelial carcinoma (UC).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e16002-e16002
Author(s):  
Vaibhav G. Patel ◽  
Russell Bailey McBride ◽  
Ana Collazo Lorduy ◽  
Mireia Castillo-Martin ◽  
Eugene K. Cha ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Pik3ca Mutation ◽  
Prognostic Significance ◽  
Muscle Invasive

The expression and clinical significance of PD-L1 in patients with upper tract urothelial carcinoma.

2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 444-444
Author(s):  
Xinan Sheng ◽  
Zhisong He ◽  
Yan Kong ◽  
Zhihong Chi ◽  
Lu Si ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Tumor Cell ◽  
Urothelial Carcinoma ◽  
Tumor Staging ◽  
Prognostic Significance ◽  
Upper Tract Urothelial Carcinoma ◽  
Tumor Cell Membrane ◽  
Upper Tract ◽  
Bladder Urothelial Carcinoma ◽  
N Classification

444 Background: Primary upper tract urothelial carcinoma (UTUC) is rare. In China UTUCs are more common than in Western populations and account for 20–30% of all TCCs.An antibody that targets programmed death ligand-1 (PD-L1) pathway has been shown to be active towards various types of cancer including bladder urothelial carcinoma. In this study, we investigated the PD-L1 expression and prognostic significance in UTUC. Methods: Formalin-fixed paraffin-embedded tumor samples from 78 patients with upper tract urothelial carcinoma from Peking University Cancer Hospital and Peking Universiy First Hospital were retrieved. PD-L1 expression was evaluated by immunohistochemistry using rabbit monoclonal anti-PD-L1 antibody. PD-L1 positivity on tumor cell membrane was defined as ≥ 1% of tumor cell membrane staining.The clinical data of patients were retrospective collected. The multivariate analysis was used to assess the association of PD-L1 expressionwith tumor staging, pathological N classification, whether firstly diagnosed with metastasis, disease free survival(DFS) and overall survival (OS) in patients. Results: The positive rates of PD-L1 expression were 42.3% (33/78) for upper tract urothelial carcinoma. Sex,location, pathological tumor staging, pathological N classification, whether firstly diagnosed with metastasis did not correlate with PD-L1 expression. In patients with upper tract UC, PD-L1 expression was not associated with DFS and OS on univariate analyses. Conclusions: To our knowledge, this is first study about PD-L1 expression in UTUC patients. In this study, We found the PD-L1 expression in UTUC was higher than in the bladder urothelial carcinoma. It means anti-PD-L1 treatment may be better for advanced UTUC. There was no correlation between PD-L1 expression and outcome.

scholarly journals Prognostic significance of replication protein A (RPA) expression levels in bladder urothelial carcinoma

2010 ◽  
Vol 108 (2b) ◽  
pp. E59-E65 ◽  
Author(s):  
Georgia Levidou ◽  
Hariklia Gakiopoulou ◽  
Nikolaos Kavantzas ◽  
Angelica A. Saetta ◽  
Maria Karlou ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Protein A ◽  
Prognostic Significance ◽  
Replication Protein A ◽  
Replication Protein ◽  
Expression Levels ◽  
Bladder Urothelial Carcinoma
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