The in vitro effects of extracellular adenosine triphosphate on the ultrastructure of Trypanosoma cruzi epimastigotes

1997 ◽  
Vol 83 (6) ◽  
pp. 624-626 ◽  
Author(s):  
B. J. Bogitsh ◽  
R. Ribeiro-Rodrigues ◽  
C. E. Carter
Keyword(s):  
Trypanosoma Cruzi ◽  
Adenosine Triphosphate ◽  
Extracellular Adenosine ◽  
In Vitro Effects

In vitro effects of suramin on Trypanosoma cruzi

2008 ◽  
Vol 31 (3) ◽  
pp. 282-286 ◽  
Author(s):  
Danielle Frias Ribeiro Bisaggio ◽  
Camila Marques Adade ◽  
Thaïs Souto-Padrón
Keyword(s):  
Trypanosoma Cruzi ◽  
In Vitro Effects

Transformation of Chick Oviduct Progesterone Receptor in Vitro: Effects of Hormone, Salt, Heat, and Adenosine Triphosphate*

Endocrinology ◽  
1985 ◽  
Vol 116 (4) ◽  
pp. 1267-1274 ◽  
Author(s):  
V. K. MOUDGIL ◽  
T. E. EESSALU ◽  
T. BUCHOU ◽  
J.-M. RENOIR ◽  
J. MESTER ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Adenosine Triphosphate ◽  
In Vitro Effects

scholarly journals In vitro effects of citral on Trypanosoma cruzi metacyclogenesis

2010 ◽  
Vol 105 (8) ◽  
pp. 1026-1032 ◽  
Author(s):  
Josiane Cardoso ◽  
Maurilio José Soares
Keyword(s):  
Trypanosoma Cruzi ◽  
In Vitro Effects

In Vivo and in Vitro Effects of Cyclosporin A on Trypanosoma Cruzi *

1985 ◽  
Vol 34 (5) ◽  
pp. 861-865 ◽  
Author(s):  
R. E. McCabe ◽  
J. S. Remington ◽  
F. G. Araujo
Keyword(s):  
Trypanosoma Cruzi ◽  
Cyclosporin A ◽  
In Vitro Effects

Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi

2004 ◽  
Vol 23 (3) ◽  
pp. 273-285 ◽  
Author(s):  
Luciana R. Garzoni ◽  
Aura Caldera ◽  
Maria de Nazareth L. Meirelles ◽  
Solange L.de Castro ◽  
Roberto Docampo ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Farnesyl Pyrophosphate ◽  
Farnesyl Pyrophosphate Synthase ◽  
In Vitro Effects ◽  
Synthase Inhibitor

In vitro effects of prodigiosin and other antibiotics on Trypanosoma cruzi

1953 ◽  
Vol 2 (2) ◽  
pp. 125-128 ◽  
Author(s):  
W.L McRary ◽  
E.L. Beaver ◽  
E.R. Noble
Keyword(s):  
Trypanosoma Cruzi ◽  
In Vitro Effects

scholarly journals Dendritic cells exposed to extracellular adenosine triphosphate acquire the migratory properties of mature cells and show a reduced capacity to attract type 1 T lymphocytes

Blood ◽  
2002 ◽  
Vol 99 (5) ◽  
pp. 1715-1722 ◽  
Author(s):  
Andrea la Sala ◽  
Silvia Sebastiani ◽  
Davide Ferrari ◽  
Francesco Di Virgilio ◽  
Marco Idzko ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Adenosine Triphosphate ◽  
Chemokine Receptor ◽  
Messenger Rna ◽  
Receptor Expression ◽  
T Lymphocyte Subsets ◽  
Chemokine Production ◽  
Extracellular Adenosine

We previously reported that chronic stimulation with low, noncytotoxic doses of extracellular adenosine triphosphate (ATP) induced a distorted maturation of dendritic cells (DCs) and impaired their capacity to initiate T-helper (Th) 1 responses in vitro. Here, we examined the effects of ATP on chemokine-receptor expression and chemokine production by DCs. ATP strongly induced expression of CXC chemokine receptor 4 on both immature and lipopolysaccharide (LPS)–stimulated DCs and slightly up-regulated CC chemokine receptor (CCR) 7 on both DC types. In contrast, ATP reduced CCR5 expression on immature DCs. These effects were confirmed at both the messenger RNA and protein levels and were not produced by uridine triphosphate (UTP). Consistent with the changed receptor expression, ATP increased migration and intracellular calcium of immature and mature DCs to stromal-derived factor 1 (CXC ligand [CXCL] 12) and macrophage inflammatory protein [MIP] 3β (CC ligand [CCL] 19), whereas responses to MIP-1β (CCL4) were reduced. DCs are an important source of chemokines influencing recruitment of distinct T-lymphocyte subsets. ATP, but not UTP, significantly reduced LPS-induced production of interferon-inducible protein 10 (CXCL10) and regulated upon activation, normal T-cell expressed and secreted chemokine (CCL5); increased secretion of macrophage-derived chemokine (CCL22); and did not change production of thymus and activation-regulated chemokine (CCL17). Consistent with these findings, supernatants from ATP-treated mature DCs attracted Th1 and T-cytotoxic 1 cells less efficiently, whereas migration of Th2 and T cytotoxic 2 cells was not affected. Our data suggest that ATP provides a signal for enhanced lymph node localization of DCs but that it may, at the same time, diminish the capacity of DCs to amplify type 1 immune responses.

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