Two-stage association study in Chinese Han identifies two independent associations in CCR1/CCR3 locus as candidate for Behçet’s disease susceptibility

2012 ◽  
Vol 131 (12) ◽  
pp. 1841-1850 ◽  
Author(s):  
Shengping Hou ◽  
Xiang Xiao ◽  
Fuzhen Li ◽  
Zhengxuan Jiang ◽  
Aize Kijlstra ◽  
...  
Keyword(s):  
Association Study ◽  
Behçet’S Disease ◽  
Disease Susceptibility ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han ◽  
Two Stage ◽  
Behcet's Disease

STAT4 polymorphism in a Chinese Han population with Vogt–Koyanagi–Harada syndrome and Behçet's disease

2010 ◽  
Vol 71 (7) ◽  
pp. 723-726 ◽  
Author(s):  
Ke Hu ◽  
Peizeng Yang ◽  
Zhengxuan Jiang ◽  
Shengping Hou ◽  
Liping Du ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Han Population

scholarly journals Association of LACC1, CEBPB-PTPN1, RIPK2 and ADO-EGR2 with ocular Behcet’s disease in a Chinese Han population

2018 ◽  
Vol 102 (9) ◽  
pp. 1308-1314 ◽  
Author(s):  
Pengcheng Wu ◽  
Liping Du ◽  
Shengping Hou ◽  
Guannan Su ◽  
Lu Yang ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Meta Analysis ◽  
Allelic Association ◽  
Nucleotide Polymorphisms ◽  
Genetic Loci ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Genome Wide

BackgroundAn Immunochip study recently identified the association of a number of new genetic loci with Behcet’s disease (BD).ObjectiveTo confirm the association between new genetic loci reported in an Immunochip study and BD in a Han Chinese population.MethodsA two-stage association study was carried out in 1238 patients with BD and 1458 healthy controls. Twenty-two candidate single nucleotide polymorphisms (SNPs) were selected for genotyping by iPLEXGold genotyping or TaqMan SNP assays and a meta-analysis was performed for significantly associated markers.ResultsThe results showed that four SNPs (LACC1/rs9316059, CEBPB-PTPN1/rs913678, ADO-EGR2/rs224127 and RIPK2/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: pc=4.95×10−8, OR=0.687; rs913678 C allele: pc=3.01×10−4, OR=1.297; rs224127 A allele: pc=3.77×10−4, OR=1.274; rs10094579 A allele: pc=6.93×10−4, OR=1.302). For four SNPs tested by meta-analysis, the association with BD was strengthened and all exceeded genome-wide significance (rs9316059: p=2.96×10−16; rs913678: p=2.09×10−16; rs224127: p=5.28×10−13; rs10094579: p=9.21×10−11).ConclusionsOur findings confirmed the association of four loci (LACC1, CEBPB-PTPN1, ADO-EGR2 and RIPK2) in Chinese Han patients with BD.

Weak association of a TNFRSF1A polymorphism with Behcet's disease in Chinese Han

2020 ◽  
Vol 196 ◽  
pp. 108045
Author(s):  
Lili Hu ◽  
Handan Tan ◽  
Qingfeng Cao ◽  
Gangxiang Yuan ◽  
Changwei Huang ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Weak Association

scholarly journals Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

2010 ◽  
Vol 42 (8) ◽  
pp. 698-702 ◽  
Author(s):  
Elaine F Remmers ◽  
Fulya Cosan ◽  
Yohei Kirino ◽  
Michael J Ombrello ◽  
Neslihan Abaci ◽  
...  
Keyword(s):  
Association Study ◽  
Mhc Class I ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Class I ◽  
Behcet's Disease ◽  
Genome Wide

IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population

2010 ◽  
Vol 69 (7) ◽  
pp. 1325-1328 ◽  
Author(s):  
Z. Jiang ◽  
P. Yang ◽  
S. Hou ◽  
L. Du ◽  
L. Xie ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Behcet's Disease ◽  
Han Population

Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behçet's disease

2012 ◽  
Vol 64 (8) ◽  
pp. 2761-2772 ◽  
Author(s):  
Joana M. Xavier ◽  
Farhad Shahram ◽  
Fereydoun Davatchi ◽  
Alexandra Rosa ◽  
Jorge Crespo ◽  
...  
Keyword(s):  
Association Study ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Iranian Patients
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