Orchestrating cellular signaling pathways—the cellular “conductor” protein tyrosine phosphatase interacting protein 51 (PTPIP51)

2016 ◽  
Vol 368 (3) ◽  
pp. 411-423 ◽  
Author(s):  
Alexander Brobeil ◽  
Eric Dietel ◽  
Stefan Gattenlöhner ◽  
Monika Wimmer
Keyword(s):  
Signaling Pathways ◽  
Protein Tyrosine Phosphatase ◽  
Cellular Signaling ◽  
Tyrosine Phosphatase ◽  
Interacting Protein ◽  
Protein Tyrosine

The Involvement of the Mammalian Target of Rapamycin, Protein Tyrosine Phosphatase 1b and Dipeptidase 4 Signaling Pathways in Cancer and Diabetes: A Narrative Review

2020 ◽  
Vol 20 ◽  
Author(s):  
Jiajia Zhang ◽  
Ning Wu ◽  
Dayong Shi
Keyword(s):  
Signaling Pathways ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Mammalian Target Of Rapamycin ◽  
Eukaryotic Cell ◽  
Target Of Rapamycin ◽  
Protein Tyrosine Phosphatase 1B ◽  
Protein Tyrosine ◽  
Transduction Mechanisms ◽  
Specific Proteins

Background: The mammalian target of rapamycin (mTOR), protein tyrosine phosphatase 1b (PTP1B) and dipeptidase 4 (DPP4) signaling pathways regulate eukaryotic cell proliferation and metabolism. Previous researches described different transduction mechanisms in the progression of cancer and diabetes. Methodology: We reviewed recent advances in the signal transduction pathways of mTOR, PTP1B and DPP4 regulation and determined the crosstalk and common pathway in diabetes and cancer. Results: We showed that according to numerous past studies, the proteins participate in the signaling networks for both diseases. Conclusion: There are common pathways and specific proteins involved in diabetes and cancer. This article demonstrates and explains the potential mechanisms of association and future prospects for targeting these proteins in pharmacological studies.

Identification of integrin α1 as an interacting protein of protein tyrosine phosphatase PRL-3

2006 ◽  
Vol 342 (1) ◽  
pp. 179-183 ◽  
Author(s):  
Lirong Peng ◽  
Genglin Jin ◽  
Li Wang ◽  
Jianpin Guo ◽  
Lin Meng ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Interacting Protein ◽  
Protein Tyrosine
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