scholarly journals Comparative efficacy of stem cells and secretome in articular cartilage regeneration: a systematic review and meta-analysis

2018 ◽  
Vol 375 (2) ◽  
pp. 329-344 ◽  
Author(s):  
Suleiman Alhaji Muhammad ◽  
Norshariza Nordin ◽  
Muhammad Zulfadli Mehat ◽  
Sharida Fakurazi
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Articular Cartilage ◽  
Meta Analysis ◽  
Cartilage Regeneration ◽  
Comparative Efficacy ◽  
Articular Cartilage Regeneration

Articular cartilage regeneration by activated skeletal stem cells

2021 ◽  
Author(s):  
Matthew P Murphy ◽  
Lauren S Koepke ◽  
Michael T Lopez ◽  
Xinming Tong ◽  
Thomas H Ambrosi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals Adipose-Derived Mesenchymal Stem Cells for the Treatment of Articular Cartilage: A Systematic Review on Preclinical and Clinical Evidence

2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Francesco Perdisa ◽  
Natalia Gostyńska ◽  
Alice Roffi ◽  
Giuseppe Filardo ◽  
Maurilio Marcacci ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Clinical Evidence ◽  
Cartilage Regeneration ◽  
Therapeutic Approaches ◽  
Differentiated Cells ◽  
Cartilage Disease

Among the current therapeutic approaches for the regeneration of damaged articular cartilage, none has yet proven to offer results comparable to those of native hyaline cartilage. Recently, it has been claimed that the use of mesenchymal stem cells (MSCs) provides greater regenerative potential than differentiated cells, such as chondrocytes. Among the different kinds of MSCs available, adipose-derived mesenchymal stem cells (ADSCs) are emerging due to their abundancy and easiness to harvest. However, their mechanism of action and potential for cartilage regeneration are still under investigation, and many other aspects still need to be clarified. The aim of this systematic review is to give an overview ofin vivostudies dealing with ADSCs, by summarizing the main evidence for the treatment of cartilage disease of the knee.

scholarly journals Which is better for articular cartilage regeneration, cultured stem cells or concentrated stromal cells?

2020 ◽  
Vol 8 (13) ◽  
pp. 836-836
Author(s):  
Dong Hwan Lee ◽  
Chae-Gwan Kong ◽  
Yong-Woon Shin ◽  
Saif Ahmed ◽  
Asode Ananthram Shetty ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Stromal Cells ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals Clinical Application Status of Articular Cartilage Regeneration Techniques: Tissue-Engineered Cartilage Brings New Hope

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Shuangpeng Jiang ◽  
Weimin Guo ◽  
Guangzhao Tian ◽  
Xujiang Luo ◽  
Liqing Peng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Clinical Application ◽  
Cartilage Regeneration ◽  
Engineering Technology ◽  
Cell Scaffold ◽  
Repair Ability ◽  
Seed Cells ◽  
Engineered Cartilage ◽  
Articular Cartilage Regeneration

Hyaline articular cartilage lacks blood vessels, lymphatics, and nerves and is characterised by limited self-repair ability following injury. Traditional techniques of articular cartilage repair and regeneration all have certain limitations. The development of tissue engineering technology has brought hope to the regeneration of articular cartilage. The strategies of tissue-engineered articular cartilage can be divided into three types: “cell-scaffold construct,” cell-free, and scaffold-free. In “cell-scaffold construct” strategies, seed cells can be autologous chondrocytes or stem. Among them, some commercial products with autologous chondrocytes as seed cells, such as BioSeed®-C and CaReS®, have been put on the market and some products are undergoing clinical trials, such as NOVOCART® 3D. The stem cells are mainly pluripotent stem cells and mesenchymal stem cells from different sources. Cell-free strategies that indirectly utilize the repair and regeneration potential of stem cells have also been used in clinical settings, such as TruFit and MaioRegen. Finally, the scaffold-free strategy is also a new development direction, and the short-term repair results of related products, such as NOVOCART® 3D, are encouraging. In this paper, the commonly used techniques of articular cartilage regeneration in surgery are reviewed. By studying different strategies and different seed cells, the clinical application status of tissue-engineered articular cartilage is described in detail.

scholarly journals Synovial mesenchymal stem cells from “super-healer” mice directly contribute to articular cartilage regeneration

2016 ◽  
Vol 24 ◽  
pp. S13-S14
Author(s):  
C.L. Jablonski ◽  
J. Mak ◽  
C. Leonard ◽  
K.M. Stevens ◽  
P. Colarusso ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-25
Author(s):  
Shuangpeng Jiang ◽  
Guangzhao Tian ◽  
Xu Li ◽  
Zhen Yang ◽  
Fuxin Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Research Progress ◽  
Therapeutic Effects ◽  
Physical And Mental Health ◽  
Paracrine Effects ◽  
Regeneration Strategies ◽  
Articular Cartilage Regeneration

Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has entered a new stage and is considered the most promising way to regenerate articular cartilage. In terms of theories on the mechanism, it was thought that stem cell-mediated articular cartilage regeneration was achieved through the directional differentiation of stem cells into chondrocytes. However, recent evidence has shown that the stem cell secretome plays an important role in biological processes such as the immune response, inflammation regulation, and drug delivery. At the same time, the stem cell secretome can effectively mediate the process of tissue regeneration. This new theory has attributed the therapeutic effect of stem cells to their paracrine effects. The application of stem cells is not limited to exogenous stem cell transplantation. Endogenous stem cell homing and in situ regeneration strategies have received extensive attention. The application of stem cell derivatives, such as conditioned media, extracellular vesicles, and extracellular matrix, is an extension of stem cell paracrine theory. On the other hand, stem cell pretreatment strategies have also shown promising therapeutic effects. This article will systematically review the latest developments in these areas, summarize challenges in articular cartilage regeneration strategies involving stem cells, and describe prospects for future development.

scholarly journals Articular Cartilage Regeneration with Stem Cells

10.5772/26911 ◽  
2011 ◽  
Author(s):  
Khay-Yong Saw ◽  
Adam Anz ◽  
Kathryne Stabile ◽  
Caroline SY ◽  
Shahrin Merican ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration
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