scholarly journals Research Progress on Stem Cell Therapies for Articular Cartilage Regeneration

2021 ◽  
Vol 2021 ◽  
pp. 1-25
Author(s):  
Shuangpeng Jiang ◽  
Guangzhao Tian ◽  
Xu Li ◽  
Zhen Yang ◽  
Fuxin Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Research Progress ◽  
Therapeutic Effects ◽  
Physical And Mental Health ◽  
Paracrine Effects ◽  
Regeneration Strategies ◽  
Articular Cartilage Regeneration

Injury of articular cartilage can cause osteoarthritis and seriously affect the physical and mental health of patients. Unfortunately, current surgical treatment techniques that are commonly used in the clinic cannot regenerate articular cartilage. Regenerative medicine involving stem cells has entered a new stage and is considered the most promising way to regenerate articular cartilage. In terms of theories on the mechanism, it was thought that stem cell-mediated articular cartilage regeneration was achieved through the directional differentiation of stem cells into chondrocytes. However, recent evidence has shown that the stem cell secretome plays an important role in biological processes such as the immune response, inflammation regulation, and drug delivery. At the same time, the stem cell secretome can effectively mediate the process of tissue regeneration. This new theory has attributed the therapeutic effect of stem cells to their paracrine effects. The application of stem cells is not limited to exogenous stem cell transplantation. Endogenous stem cell homing and in situ regeneration strategies have received extensive attention. The application of stem cell derivatives, such as conditioned media, extracellular vesicles, and extracellular matrix, is an extension of stem cell paracrine theory. On the other hand, stem cell pretreatment strategies have also shown promising therapeutic effects. This article will systematically review the latest developments in these areas, summarize challenges in articular cartilage regeneration strategies involving stem cells, and describe prospects for future development.

scholarly journals Xenogenic Implantation of Equine Synovial Fluid-Derived Mesenchymal Stem Cells Leads to Articular Cartilage Regeneration

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Mohammed Zayed ◽  
Steven Newby ◽  
Nabil Misk ◽  
Robert Donnell ◽  
Madhu Dhar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Synovial Fluid ◽  
Cartilage Repair ◽  
Cartilage Regeneration ◽  
Large Animal

Horses are widely used as large animal preclinical models for cartilage repair studies, and hence, there is an interest in using equine synovial fluid-derived mesenchymal stem cells (SFMSCs) in research and clinical applications. Since, we have previously reported that similar to bone marrow-derived MSCs (BMMSCs), SFMSCs may also exhibit donor-to-donor variations in their stem cell properties; the current study was carried out as a proof-of-concept study, to compare the in vivo potential of equine BMMSCs and SFMSCs in articular cartilage repair. MSCs from these two sources were isolated from the same equine donor. In vitro analyses confirmed a significant increase in COMP expression in SFMSCs at day 14. The cells were then encapsulated in neutral agarose scaffold constructs and were implanted into two mm diameter full-thickness articular cartilage defect in trochlear grooves of the rat femur. MSCs were fluorescently labeled, and one week after treatment, the knee joints were evaluated for the presence of MSCs to the injured site and at 12 weeks were evaluated macroscopically, histologically, and then by immunofluorescence for healing of the defect. The macroscopic and histological evaluations showed better healing of the articular cartilage in the MSCs’ treated knee than in the control. Interestingly, SFMSC-treated knees showed a significantly higher Col II expression, suggesting the presence of hyaline cartilage in the healed defect. Data suggests that equine SFMSCs may be a viable option for treating osteochondral defects; however, their stem cell properties require prior testing before application.

Articular cartilage regeneration by activated skeletal stem cells

2021 ◽  
Author(s):  
Matthew P Murphy ◽  
Lauren S Koepke ◽  
Michael T Lopez ◽  
Xinming Tong ◽  
Thomas H Ambrosi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

In vivo articular cartilage regeneration through infrapatellar adipose tissue derived stem cell in nanofiber polycaprolactone scaffold

2019 ◽  
Vol 57 ◽  
pp. 49-56 ◽  
Author(s):  
Parviz Vahedi ◽  
Seyedhosein Jarolmasjed ◽  
Hajar Shafaei ◽  
Leila Roshangar ◽  
Jafar Soleimani Rad ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Stem Cell ◽  
Articular Cartilage ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals Which is better for articular cartilage regeneration, cultured stem cells or concentrated stromal cells?

2020 ◽  
Vol 8 (13) ◽  
pp. 836-836
Author(s):  
Dong Hwan Lee ◽  
Chae-Gwan Kong ◽  
Yong-Woon Shin ◽  
Saif Ahmed ◽  
Asode Ananthram Shetty ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Stromal Cells ◽  
Cartilage Regeneration ◽  
Articular Cartilage Regeneration

scholarly journals Clinical Application Status of Articular Cartilage Regeneration Techniques: Tissue-Engineered Cartilage Brings New Hope

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Shuangpeng Jiang ◽  
Weimin Guo ◽  
Guangzhao Tian ◽  
Xujiang Luo ◽  
Liqing Peng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Articular Cartilage ◽  
Clinical Application ◽  
Cartilage Regeneration ◽  
Engineering Technology ◽  
Cell Scaffold ◽  
Repair Ability ◽  
Seed Cells ◽  
Engineered Cartilage ◽  
Articular Cartilage Regeneration

Hyaline articular cartilage lacks blood vessels, lymphatics, and nerves and is characterised by limited self-repair ability following injury. Traditional techniques of articular cartilage repair and regeneration all have certain limitations. The development of tissue engineering technology has brought hope to the regeneration of articular cartilage. The strategies of tissue-engineered articular cartilage can be divided into three types: “cell-scaffold construct,” cell-free, and scaffold-free. In “cell-scaffold construct” strategies, seed cells can be autologous chondrocytes or stem. Among them, some commercial products with autologous chondrocytes as seed cells, such as BioSeed®-C and CaReS®, have been put on the market and some products are undergoing clinical trials, such as NOVOCART® 3D. The stem cells are mainly pluripotent stem cells and mesenchymal stem cells from different sources. Cell-free strategies that indirectly utilize the repair and regeneration potential of stem cells have also been used in clinical settings, such as TruFit and MaioRegen. Finally, the scaffold-free strategy is also a new development direction, and the short-term repair results of related products, such as NOVOCART® 3D, are encouraging. In this paper, the commonly used techniques of articular cartilage regeneration in surgery are reviewed. By studying different strategies and different seed cells, the clinical application status of tissue-engineered articular cartilage is described in detail.

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