Routine vs ``on demand'' postoperative ERCP for small bile duct calculi detected at intraoperative cholangiography

2000 ◽  
Vol 14 (12) ◽  
pp. 1123-1126 ◽  
Author(s):  
B. J. Ammori ◽  
K. Birbas ◽  
D. Davides ◽  
A. Vezakis ◽  
M. Larvin ◽  
...  
Keyword(s):  
Bile Duct ◽  
Intraoperative Cholangiography ◽  
On Demand ◽  
Small Bile Duct ◽  
Bile Duct Calculi

Bile acid stimulation of small bile duct proliferation requires de novo expression of the apical bile acid transporter (ABAT)

2001 ◽  
Vol 120 (5) ◽  
pp. A1-A1
Author(s):  
G ALPINI ◽  
S GLASER ◽  
J PHINIZY ◽  
N KANNO ◽  
H FRANCIS ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
De Novo ◽  
Bile Duct Proliferation ◽  
Bile Acid Transporter ◽  
Small Bile Duct ◽  
Acid Transporter ◽  
Stimulation Of

scholarly journals Typing FGFR2 translocation determines the response to targeted therapy of intrahepatic cholangiocarcinomas

2021 ◽  
Vol 12 (3) ◽  
Author(s):  
Xiaohong Pu ◽  
Qing Ye ◽  
Jing Cai ◽  
Xin Yang ◽  
Yao Fu ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Bile Duct ◽  
Kinase Inhibitors ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Chromosomal Translocations ◽  
Small Bile Duct ◽  
Druggable Targets ◽  
Inhibitor Treatment ◽  
Specific Inhibitors

AbstractChromosomal translocations involving fibroblast growth factor receptor 2 (FGFR2) gene at the breakpoints are common genetic lesions in intrahepatic cholangiocarcinoma (ICC) and the resultant fusion protein products have emerged as promising druggable targets. However, predicting the sensitivity of FGFR2 fusions to FGFR kinase inhibitors is crucial to the prognosis of the ICC-targeted therapy. Here, we report identification of nine FGFR2 translocations out of 173 (5.2%) ICC tumors. Although clinicopathologically these FGFR2 translocation bearing ICC tumors are indistinguishable from the rest of the cohort, they are invariably of the mass-forming type originated from the small bile duct. We show that the protein products of FGFR2 fusions can be classified into three subtypes based on the breaking positions of the fusion partners: the classical fusions that retain the tyrosine kinase (TK) and the Immunoglobulin (Ig)-like domains (n = 6); the sub-classical fusions that retain only the TK domain without the Ig-like domain (n = 1); and the non-classical fusions that lack both the TK and Ig-like domains (n = 2). We demonstrate that cholangiocarcinoma cells engineered to express the classical and sub-classical fusions show sensitivity to FGFR-specific kinase inhibitors as evident by the suppression of MAPK/ERK and AKT/PI3K activities following the inhibitor treatment. Furthermore, the kinase-deficient mutant of the sub-classical fusion also lost its sensitivity to the FGFR-specific inhibitors. Taken together, our study suggests that it is essential to determine the breakpoint and type of FGFR2 fusions in the small bile duct subtype of ICC for the targeted treatment.

A Death Following Complications of Roentgenologic Nonoperative Manipulation of Common Bile Duct Calculi

Radiology ◽  
1977 ◽  
Vol 123 (3) ◽  
pp. 585-586 ◽  
Author(s):  
Edward P. Polack ◽  
Maurice H. Fainsinger ◽  
Salvatore V. Bonnano
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Common Bile Duct Calculi ◽  
Bile Duct Calculi

Extracorporeal Shock-Wave Lithotripsy for Bile Duct Calculi

1998 ◽  
Vol 175 (1) ◽  
pp. 10-13 ◽  
Author(s):  
David M White ◽  
Roy J Correa ◽  
Robert P Gibbons ◽  
Terrence J Ball ◽  
Richard J Kozarek ◽  
...  
Keyword(s):  
Shock Wave ◽  
Bile Duct ◽  
Extracorporeal Shock Wave Lithotripsy ◽  
Shock Wave Lithotripsy ◽  
Extracorporeal Shock Wave ◽  
Bile Duct Calculi

Detection of Small Bile Duct Stones by Intraductal US in Patients with Highly Suspected Choledocholithiasis Showing No Filling Defect on ERCP

2004 ◽  
Vol 59 (5) ◽  
pp. P196 ◽  
Author(s):  
Jong Ho Moon ◽  
Sang Woo Cha ◽  
Young Koog Cheon ◽  
Young Seok Kim ◽  
Young Deok Cho ◽  
...  
Keyword(s):  
Bile Duct ◽  
Filling Defect ◽  
Bile Duct Stones ◽  
Small Bile Duct
Sign in / Sign up

Export Citation Format

Share Document