Biomarkers in the assessment of oral mucositis in head and neck cancer patients: a systematic review and meta-analysis

This systematic review and meta-analysis aimed to assess the literature about the incidence of oral mucositis and its degrees (mild, moderate, and severe), in patients undergoing head and neck cancer treatment (radiotherapy, chemotherapy, and surgery). Addressing this issue is important since oral mucositis has a negative impact on oral health and significantly deteriorates the quality of life. Therefore, a multidisciplinary team, including dentists, should be involved in the treatment. The overall oral mucositis incidence was 89.4%. The global incidence for mild, moderate, and severe degrees were 16.8%, 34.5%, and 26.4%, respectively. The high incidence rates reported in this review point out the need for greater care in terms of the oral health of these patients.

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The effects of continued smoking in head and neck cancer patients treated with radiotherapy: A systematic review and meta-analysis

Radiotherapy and Oncology ◽

10.1016/j.radonc.2019.02.021 ◽

2019 ◽

Vol 135 ◽

pp. 51-57 ◽

Cited By ~ 8

Author(s):

Justin Smith ◽

Domenico Nastasi ◽

Reece Tso ◽

Venkat Vangaveti ◽

Bronia Renison ◽

...

Keyword(s):

Systematic Review ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Meta Analysis

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A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

Supportive Care in Cancer ◽

10.1007/s00520-020-05548-0 ◽

2020 ◽

Author(s):

Catrina Davy ◽

Sharron Heathcote

Keyword(s):

Systematic Review ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Oral Mucositis

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Swallowing exercises for head and neck cancer patients: A systematic review and meta-analysis of randomized control trials

International Journal of Nursing Studies ◽

10.1016/j.ijnurstu.2020.103827 ◽

2021 ◽

Vol 114 ◽

pp. 103827

Author(s):

Kondwani Joseph Banda ◽

Hsin Chu ◽

Ching-Chiu Kao ◽

Joachim Voss ◽

Huei-Ling Chiu ◽

...

Keyword(s):

Systematic Review ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Meta Analysis ◽

Randomized Control Trials ◽

Randomized Control ◽

Swallowing Exercises

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Circulating MicroRNAs as Prognostic Molecular Biomarkers in Human Head and Neck Cancer: A Systematic Review and Meta-Analysis

Disease Markers ◽

10.1155/2019/8632018 ◽

2019 ◽

Vol 2019 ◽

pp. 1-12 ◽

Cited By ~ 3

Author(s):

Shree Ram Lamichhane ◽

Thanuja Thachil ◽

Harriet Gee ◽

Natalie Milic

Keyword(s):

Systematic Review ◽

Overall Survival ◽

Head And Neck Cancer ◽

Head And Neck ◽

Cancer Patients ◽

Neck Cancer ◽

Meta Analysis ◽

Prognostic Role ◽

Circulating Micrornas

Background. Circulating microRNAs (miRNAs) are potential molecular biomarkers for cancer detection; however, little is known about their prognostic role in head and neck cancer. This current study is aimed at evaluating the role of novel miRNAs in the survival of head and neck cancer patients. Materials and Methods. We performed a systematic literature search using online databases for articles published between December 2006 and February 2019. A meta-analysis was conducted to assess the correlation between miRNA expressions and overall survival (OS) among the selected head and neck cancer studies. After multilevel screening by reviewers, meta-analysis was performed using hazard ratios (HR) and associated 95% confidence interval (CI) of survival to calculate a pooled effect size. Result. A total of 1577 patients across 13 studies were included in the literature review, with 18 miRNAs upregulated and 4 miRNAs downregulated predicting a poor overall survival. The forest plot generated using cumulated survival data resulted in a pooled HR value of 2.943 (95% CI: 2.394-3.618) indicating a strong association of dysregulated miRNA expression with a poor outcome. Only 2 miRNAs—low levels of miR-9 and high levels of miR-483-5p—were observed in two studies, both showing a significant association with overall cancer survival. Conclusion. To our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the prognostic role of circulating miRNAs from blood in head and neck cancer patients. The combined effect estimates a HR across multiple studies and also supports the previous individual findings that an alteration in miRNA expression is highly associated with poor prognosis. This has the potential to use serum and/or plasma miRNAs as biomarkers and become novel tools for predicting the prognosis of head and neck cancer patients in the near future.

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