Primary sclerosing cholangitis in which differential diagnosis from gallbladder carcinoma was difficult

2005 ◽  
Vol 12 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Hiroyuki Kobayashi ◽  
Ryo Hosotani ◽  
Yukihiro Imai ◽  
Kaori Wada ◽  
Tatehiro Kajiwara
2015 ◽  
Author(s):  
Udayakumar Navaneethan

Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic disease characterized by inflammation and fibrosis that may involve the entire biliary tree. The fibrosis causes diffuse narrowing of the intrahepatic and extrahepatic bile ducts, and the resulting biliary stasis leads to secondary biliary cirrhosis and associated complications. This review addresses PSC through its epidemiology, etiopathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis. Figures show pouchoscopy, liver biopsy, and endoscopic retrograde cholangiopancreatography; direct peroral cholangioscopy visualization of cholangiocarcinoma; and algorithms depicting diagnosis of cholangiocarcinoma and screening for inflammatory bowel disease (IBD) in patients with PSC. Tables list characteristics of IBD in PSC, prevalence of antibodies in PSC, differential diagnosis of PSC, diagnostic approach in PSC, and risk of cancers in PSC. This review contains 6 highly rendered figures, 5 tables, and 91 references. 


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