Role of CD44 in CTL-induced acute liver injury in hepatitis B virus transgenic mice

2009 ◽  
Vol 44 (3) ◽  
pp. 218-227 ◽  
Author(s):  
Kiminori Kimura ◽  
Masahito Nagaki ◽  
Masanao Saio ◽  
Hisataka Moriwaki ◽  
Kazuhiro Kakimi
Keyword(s):  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Transgenic Mice ◽  
Acute Liver Injury ◽  
B Virus

Hepatitis B virus-induced liver injury and altered expression of carcinogen metabolising enzymes: the role of the HBx protein

1998 ◽  
Vol 102-103 ◽  
pp. 595-601 ◽  
Author(s):  
Pascale Chomarat ◽  
Jerry M Rice ◽  
Betty L Slagle ◽  
Christopher P Wild
Keyword(s):  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Altered Expression ◽  
B Virus

scholarly journals Enhancement of Hepatitis B Virus Replication by Its X Protein in Transgenic Mice

2002 ◽  
Vol 76 (5) ◽  
pp. 2579-2584 ◽  
Author(s):  
Zhenming Xu ◽  
T. S. Benedict Yen ◽  
Lanying Wu ◽  
Charles R. Madden ◽  
Wenjie Tan ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Transgenic Mice ◽  
Viral Gene Expression ◽  
Viral Gene ◽  
X Protein ◽  
Multifunctional Protein ◽  
Hbv Replication ◽  
B Virus

ABSTRACT Hepatitis B virus (HBV) X gene encodes a multifunctional protein that can regulate cellular signaling pathways, interact with cellular transcription factors, and induce hepatocellular oncogenesis. In spite of its diverse activities, the precise role of the X protein in the viral life cycle of HBV remains unclear. To investigate this question, we have produced transgenic mice that carry either the wild-type HBV genome or a mutated HBV genome incapable of expressing the 16.5-kDa X protein. Our results indicate that while the X protein is not absolutely essential for HBV replication or its maturation in transgenic mice, it can enhance viral replication, apparently by activating viral gene expression. These results demonstrate a transactivation role of the X protein in HBV replication in transgenic mice.

Acute liver injury following infection with a cytopathic strain of duck hepatitis B virus

Hepatology ◽  
1999 ◽  
Vol 29 (2) ◽  
pp. 563-571 ◽  
Author(s):  
Raymond J. Lenhoff ◽  
Carolyn A. Luscombe ◽  
Jesse Summers
Keyword(s):  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Acute Liver Injury ◽  
Duck Hepatitis B Virus ◽  
Duck Hepatitis ◽  
B Virus

Role of monokine induced by interferon-γ in liver injury induced by hepatitis B virus in mice

2012 ◽  
Vol 19 (7) ◽  
pp. 509-518 ◽  
Author(s):  
Y. J. Xia ◽  
D. Zeng ◽  
L. M. Xia ◽  
F. Yu ◽  
H. H. Lin ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Liver Injury ◽  
Hepatitis B ◽  
Interferon Γ ◽  
B Virus
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