Decreased expression of insulin and increased expression of pancreatic transcription factor PDX-1 in islets in patients with liver cirrhosis: a comparative investigation using human autopsy specimens

Abstract Fifty consecutive human autopsy specimens were studied to determine the suitability of the superficial temporal artery (STA) for use in microvascular anastomoses. Ten variations of the STA were found. The STA at the zygoma averaged 2.2 mm in outside diameter. The STA averaged 31.7 mm from the zygoma to its bifurcation, where the average outside diameter was 1.9 mm. Eight per cent of the specimens had no bifurcation, and 92% had at least one branch in a frontal or parietal distribution that was ≥1 mm. A suitable frontal branch (i.e., ≥1 mm in diameter and ≥70 mm in length) was found in 90% of the specimens, and a suitable parietal branch was found in 71%. Six specimens (12%) had an additional branch, all of which were of suitable length and diameter. Eight per cent of the specimens lacked a vessel suitable for microvascular anastomosis.

Download Full-text

Biologic Width and Morphologic Characteristics of Soft Tissues Around Immediately Loaded Implants: Studies Performed on Human Autopsy Specimens

Journal of Periodontology ◽

10.1902/jop.2009.090364 ◽

2010 ◽

Vol 81 (1) ◽

pp. 70-78 ◽

Cited By ~ 20

Author(s):

George E. Romanos ◽

Tonino Traini ◽

Carina B. Johansson ◽

Adriano Piattelli

Keyword(s):

Soft Tissues ◽

Morphologic Characteristics ◽

Autopsy Specimens ◽

Biologic Width ◽

Human Autopsy

Download Full-text

Changing Diameters of Cerebral Vessels with Age in Human Autopsy Specimens: Possible Relationships to Atherosclerotic Changes

Zentralblatt für Neurochirurgie ◽

10.1055/s-2007-1004588 ◽

2008 ◽

Vol 69 (03) ◽

pp. 139-143 ◽

Cited By ~ 4

Author(s):

O. Ozdogmus ◽

Ö. Çakmak ◽

A. Yalin ◽

D. Keklik ◽

Ý. Üzün ◽

...

Keyword(s):

Cerebral Vessels ◽

Autopsy Specimens ◽

Atherosclerotic Changes ◽

Human Autopsy

Download Full-text

SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients

10.1101/2020.08.25.265561 ◽

2020 ◽

Cited By ~ 13

Author(s):

Juan A. Pérez-Bermejo ◽

Serah Kang ◽

Sarah J. Rockwood ◽

Camille R. Simoneau ◽

David A. Joy ◽

...

Keyword(s):

Nuclear Dna ◽

Distinct Pattern ◽

Cardiac Cells ◽

Productive Infection ◽

Heart Cells ◽

Cardiac Damage ◽

Autopsy Specimens ◽

Human Ipsc ◽

Human Autopsy

ABSTRACTAlthough COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed productive infection and robust transcriptomic and morphological signatures of damage, particularly in cardiomyocytes. Transcriptomic disruption of structural proteins corroborated adverse morphologic features, which included a distinct pattern of myofibrillar fragmentation and numerous iPSC-cardiomyocytes lacking nuclear DNA. Human autopsy specimens from COVID-19 patients displayed similar sarcomeric disruption, as well as cardiomyocytes without DNA staining. These striking cytopathic features provide new insights into SARS-CoV-2 induced cardiac damage, offer a platform for discovery of potential therapeutics, and raise serious concerns about the long-term consequences of COVID-19.

Download Full-text