Evaluation of therapeutic effect of Psidium guajava root extract against the toxicity induced by Ricinus communis (castor oil) in rats

2021 ◽  
Vol 30 (5) ◽  
pp. 755-764
Author(s):  
Angela N. Amujiri ◽  
Dilibe C. Urama ◽  
Chinyere B. Chigor ◽  
Christopher D. Nwani
Keyword(s):  
Therapeutic Effect ◽  
Castor Oil ◽  
Ricinus Communis ◽  
Psidium Guajava ◽  
Root Extract

scholarly journals Kinetic and regulatory properties of cytosolic pyruvate kinase from germinating castor oil seeds

1991 ◽  
Vol 279 (2) ◽  
pp. 495-501 ◽  
Author(s):  
F E Podestá ◽  
W C Plaxton
Keyword(s):  
Pyruvate Kinase ◽  
Castor Oil ◽  
Mixed Type ◽  
Competitive Inhibition ◽  
Ricinus Communis ◽  
Cytosolic Ph ◽  
Oil Seeds ◽  
Saturation Kinetics ◽  
Regulatory Properties

The kinetic and regulatory properties of cytosolic pyruvate kinase (PKc) isolated from endosperm of germinating castor oil seeds (Ricinus communis L.) have been studied. Optimal efficiency in substrate utilization (in terms of Vmax/Km for phosphoenolpyruvate or ADP) occurred between pH 6.7 and 7.4. Enzyme activity was absolutely dependent on the presence of a bivalent and a univalent metal cation, with Mg2+ and K+ fulfilling this requirement. Mg2+ binding showed positive and negative co-operativity at pH 6.5 (h = 1.6) and pH 7.2 (h = 0.69) respectively. Hyperbolic saturation kinetics were observed with phosphoenolpyruvate (PEP) and K+, whereas ADP acted as a mixed-type inhibitor over 1 mM. Glycerol (10%, v/v) increased the S0.5(ADP) 2.3-fold and altered the pattern of nucleotide binding from hyperbolic (h = 1.0) to sigmoidal (h = 1.79) without modifying PEP saturation kinetics. No activators were identified. ATP, AMP, isocitrate, 2-oxoglutarate, malate, 2-phosphoglycerate, 2,3-bisphosphoglycerate, 3-phosphoglycerate, glycerol 3-phosphate and phosphoglycolate were the most effective inhibitors. These metabolites yielded additive inhibition when tested in pairs. ATP and 3-phosphoglycerate were mixed-type inhibitors with respect to PEP, whereas competitive inhibition was observed for other inhibitors. Inhibition by malate, 2-oxoglutarate, phosphorylated triose sugars or phosphoglycolate was far more pronounced at pH 7.2 than at pH 6.5. Although 32P-labelling studies revealed that extensive phosphorylation in vivo of soluble endosperm proteins occurred between days 3 and 5 of seed germination, no alteration in the 32P-labelling pattern of 5-day-germinated endosperm was observed after 30 min of anaerobiosis. Moreover, no evidence was obtained that PKc was a phosphoprotein in aerobic or anoxic endosperms. It is proposed that endosperm PKc activity of germinating castor seeds is enhanced after anaerobiosis through concerted decreases in ATP levels, cytosolic pH and concentrations of several key inhibitors.

Castor Oil ( Ricinus communis )

2022 ◽  
pp. 51-78
Author(s):  
Is Fatimah ◽  
Suresh Sagadevan ◽  
Baranya Murugan ◽  
Oki Muraza
Keyword(s):  
Castor Oil ◽  
Ricinus Communis

Phosphorylation of glyoxysomal malate synthase from castor oil seeds Ricinus communis L.

FEBS Letters ◽  
1988 ◽  
Vol 234 (2) ◽  
pp. 275-279 ◽  
Author(s):  
Yan-Ping Yang ◽  
Douglas D. Randall ◽  
Richard N. Trelease
Keyword(s):  
Castor Oil ◽  
Ricinus Communis ◽  
Malate Synthase ◽  
Oil Seeds ◽  
Ricinus Communis L

Antidiarrhoeal activity of the 80% methanol root extract of Thalictrum ryhnchocarpum Dill. & A. Rich and its major constituent against castor oil-induced diarrhoea in mice

2020 ◽  
Vol 36 (1) ◽  
pp. 31-40
Author(s):  
Kebede Feyisa ◽  
Daniel Bisrat ◽  
Solomon Tadesse ◽  
Kaleab Asres
Keyword(s):  
Castor Oil ◽  
Major Constituent ◽  
Root Extract

No Abstract.

scholarly journals Addition of increasing doses of ricinoleic acid from castor oil (Ricinus communis L.) in diets of Nellore steers in feedlots

2012 ◽  
Vol 21 (4) ◽  
pp. 566-576 ◽  
Author(s):  
J. Gandra ◽  
P. Nunes Gil ◽  
N. Cônsolo ◽  
E. Gandra ◽  
A. Gobesso
Keyword(s):  
Ricinoleic Acid ◽  
Castor Oil ◽  
Ricinus Communis
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