scholarly journals Effects of cerebral perfusion pressure and increased fraction of inspired oxygen on brain tissue oxygen, lactate and glucose in patients with severe head injury

2003 ◽  
Vol 145 (5) ◽  
pp. 341-350 ◽  
Author(s):  
M. Reinert ◽  
A. Barth ◽  
H. U. Rothen ◽  
B. Schaller ◽  
J. Takala ◽  
...  
Keyword(s):  
Head Injury ◽  
Brain Tissue ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Severe Head Injury ◽  
Perfusion Pressure ◽  
Tissue Oxygen ◽  
Brain Tissue Oxygen ◽  
Fraction Of Inspired Oxygen ◽  
Inspired Oxygen

Brain tissue pO2 in relation to cerebral perfusion pressure, TCD findings and TCD-CO2-reactivity after severe head injury

1996 ◽  
Vol 138 (4) ◽  
pp. 425-434 ◽  
Author(s):  
J. Dings ◽  
J. Meixensberger ◽  
J. Amschler ◽  
B. Hamelbeck ◽  
K. Roosen
Keyword(s):  
Head Injury ◽  
Brain Tissue ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Severe Head Injury ◽  
Perfusion Pressure ◽  
Co2 Reactivity ◽  
Tissue Po2

scholarly journals Relationship between brain tissue oxygen (PbrO2) and cerebral perfusion pressure (CPP)

Critical Care ◽  
10.1186/cc14 ◽  
1997 ◽  
Vol 1 (Suppl 1) ◽  
pp. P008
Author(s):  
P Bruzzone ◽  
G Bellinzona ◽  
R Imberti ◽  
L Carnevale ◽  
S Noli ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Tissue Oxygen ◽  
Brain Tissue Oxygen

HYPERTONIC SALINE AND ITS EFFECT ON INTRACRANIAL PRESSURE, CEREBRAL PERFUSION PRESSURE, AND BRAIN TISSUE OXYGEN

Neurosurgery ◽  
2009 ◽  
Vol 65 (6) ◽  
pp. 1035-1042 ◽  
Author(s):  
Gaylan L. Rockswold ◽  
Craig A. Solid ◽  
Eduardo Paredes-Andrade ◽  
Sarah B. Rockswold ◽  
Jon T. Jancik ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Brain Tissue ◽  
Cerebral Perfusion Pressure ◽  
Hypertonic Saline ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Tissue Oxygen ◽  
Brain Tissue Oxygen

Reactivity of Brain Tissue Oxygen to Change in Cerebral Perfusion Pressure in Head Injured Patients

2009 ◽  
Vol 10 (3) ◽  
pp. 274-279 ◽  
Author(s):  
Danila K. Radolovich ◽  
Marek Czosnyka ◽  
Ivan Timofeev ◽  
Andrea Lavinio ◽  
Peter Hutchinson ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Tissue Oxygen ◽  
Brain Tissue Oxygen ◽  
Head Injured ◽  
Injured Patients

Transient Changes in Brain Tissue Oxygen in Response to Modifications of Cerebral Perfusion Pressure: An Observational Study

2010 ◽  
Vol 110 (1) ◽  
pp. 165-173 ◽  
Author(s):  
Danila K. Radolovich ◽  
Marek Czosnyka ◽  
Ivan Timofeev ◽  
Andrea Lavinio ◽  
Dong-Joo Kim ◽  
...  
Keyword(s):  
Observational Study ◽  
Brain Tissue ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Perfusion Pressure ◽  
Tissue Oxygen ◽  
Brain Tissue Oxygen

Intracranial hypertension and cerebral perfusion pressure: influence on neurological deterioration and outcome in severe head injury

2000 ◽  
Vol 92 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Niels Juul ◽  
Gabrielle F. Morris ◽  
Sharon B. Marshall ◽  
_ _ ◽  
Lawrence F. Marshall
Keyword(s):  
Head Injury ◽  
Intracranial Hypertension ◽  
Cerebral Perfusion Pressure ◽  
Cerebral Perfusion ◽  
Severe Head Injury ◽  
Perfusion Pressure ◽  
Neurological Deterioration ◽  
Double Blind ◽  
Content Type ◽  
Fine Print

Object. Recently, a renewed emphasis has been placed on managing severe head injury by elevating cerebral perfusion pressure (CPP), which is defined as the mean arterial pressure minus the intracranial pressure (ICP). Some authors have suggested that CPP is more important in influencing outcome than is intracranial hypertension, a hypothesis that this study was designed to investigate.Methods. The authors examined the relative contribution of these two parameters to outcome in a series of 427 patients prospectively studied in an international, multicenter, randomized, double-blind trial of the N-methyl-d-aspartate antagonist Selfotel. Mortality rates rose from 9.6% in 292 patients who had no clinically defined episodes of neurological deterioration to 56.4% in 117 patients who suffered one or more of these episodes; 18 patients were lost to follow up. Correspondingly, favorable outcome, defined as good or moderate on the Glasgow Outcome Scale at 6 months, fell from 67.8% in patients without neurological deterioration to 29.1% in those with neurological deterioration. In patients who had clinical evidence of neurological deterioration, the relative influence of ICP and CPP on outcome was assessed. The most powerful predictor of neurological worsening was the presence of intracranial hypertension (ICP ≥ 20 mm Hg) either initially or during neurological deterioration. There was no correlation with the CPP as long as the CPP was greater than 60 mm Hg.Conclusions. Treatment protocols for the management of severe head injury should emphasize the immediate reduction of raised ICP to less than 20 mm Hg if possible. A CPP greater than 60 mm Hg appears to have little influence on the outcome of patients with severe head injury.

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