Interactions between tiagabine and conventional antiepileptic drugs in the rat model of complex partial seizures

2008 ◽  
Vol 115 (5) ◽  
pp. 661-667 ◽  
Author(s):  
K. K. Borowicz ◽  
M. Zadrozniak ◽  
J. J. Luszczki ◽  
S. J. Czuczwar
Keyword(s):  
Antiepileptic Drugs ◽  
Rat Model ◽  
Partial Seizures ◽  
Complex Partial Seizures

scholarly journals Effects of valproate and other antiepileptic drugs on brain glutamate, glutamine, and GABA in patients with refractory complex partial seizures

Seizure ◽  
1999 ◽  
Vol 8 (2) ◽  
pp. 120-127 ◽  
Author(s):  
O.A.C. Petroff ◽  
D.L. Rothman ◽  
K.L. Behar ◽  
F. Hyder ◽  
R.H. Mattson
Keyword(s):  
Antiepileptic Drugs ◽  
Partial Seizures ◽  
Complex Partial Seizures

Potassium currents in rat cortical neurons in culture are enhanced by the antiepileptic drug carbamazepine

1990 ◽  
Vol 68 (4) ◽  
pp. 545-547 ◽  
Author(s):  
C. Zona ◽  
V. Tancredi ◽  
E. Palma ◽  
G. C. Pirrone ◽  
M. Avoli
Keyword(s):  
Antiepileptic Drug ◽  
Antiepileptic Drugs ◽  
Cortical Neurons ◽  
Potassium Currents ◽  
Patch Clamping ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Voltage Dependent ◽  
Rat Neocortex ◽  
Rat Cortical Neurons

We report that carbamazepine (Tegretol), a drug that is useful for the treatment of complex partial seizures, enhances outward, voltage-dependent K+ currents generated by rat neocortical cells in culture and recorded with patch-clamping techniques. This effect is seen in the presence of therapeutic concentrations of carbamazepine (10–20 μM). Furthermore, at these doses carbamazepine does not influence voltage-dependent inward Na+ and Ca2+ currents recorded in these cells. The action exerted by carbamazepine on K+ currents is a novel finding and might represent an important mechanism for controlling neocortical excitability and thus the generation of epileptiform activity.Key words: potassium currents, antiepileptic drugs, carbamazepine, rat neocortex.

Time Interval Between Traumatic Brain Injury And Post Traumatic Epilepsy

2013 ◽  
Vol 21 (2) ◽  
pp. 222-228
Author(s):  
Daniel Garbin Di Luca ◽  
Glenda Corrêa Borges de Lacerda
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
First Year ◽  
Time Interval ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Post Traumatic ◽  
Faster Development ◽  
Post Traumatic Epilepsy ◽  
Traumatic Epilepsy

Introduction. The estimated time interval in which an individual can develop Post Traumatic Epilepsy (PTE) after a traumatic brain injury (TBI) is not clear. Objective. To assess the possible influence of the clinical features in the time interval between TBI and PTE develop­ment. Method. We analyzed retrospectively 400 medical records from a tertiary Brazilian hospital. We selected and reevaluated 50 patients and data was confronted with the time between TBI and PTE devel­opment by a Kaplan-Meier survival analysis. A Cox-hazard regression was also conducted to define the characteristics that could be involved in the latent period of the PTE development. Results. Patients devel­oped PTE especially in the first year (56%). We found a tendency of a faster development of PTE in patients older than 24 years (P<0.0001) and in men (P=0.03). Complex partial seizures evolving to generalized seizures were predominant in patients after moderate (37.7%) and severe (48.8%) TBIs, and simple partial seizures evolving to general­ized seizures in mild TBIs (45.5%). Conclusions. Our data suggest that the first year after a TBI is the most critical period for PTE de­velopment and those males older than 24 years could have a faster development of PTE.

Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia

2002 ◽  
Vol 50 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Matthew D Smyth ◽  
Nicholas M Barbaro ◽  
Scott C Baraban
Keyword(s):  
Antiepileptic Drugs ◽  
Rat Model ◽  
Epileptiform Activity

Postictal language dysfunction in complex partial seizures: Effect of contralateral ictal spread

Neurology ◽  
2001 ◽  
Vol 56 (11) ◽  
pp. 1590-1592 ◽  
Author(s):  
D. M. Ficker ◽  
R. Shukla ◽  
M. D. Privitera
Keyword(s):  
Partial Seizures ◽  
Complex Partial Seizures

Vagus nerve stimulation for complex partial seizures: surgical technique, safety, and efficacy

1993 ◽  
Vol 78 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Howard J. Landy ◽  
R. Eugene Ramsay ◽  
Jeremy Slater ◽  
Roy R. Casiano ◽  
Robert Morgan
Keyword(s):  
Vagus Nerve ◽  
Vocal Cord ◽  
Seizure Frequency ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Vocal Cord Dysfunction ◽  
High Current ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Stimulation Group

✓ Electrical stimulation of the vagus nerve has shown efficacy in controlling seizures in experimental models, and early clinical trials have suggested possible benefit in humans. Eleven patients with complex partial seizures were subjected to implantation of vagus nerve stimulators. Electrode contacts embedded in silicone rubber spirals were placed on the left vagus nerve in the low cervical area. A transcutaneously programmable stimulator module was placed in an infraclavicular subcutaneous pocket and connected to the electrode. One patient required replacement of the system due to electrode fracture. Another patient developed delayed ipsilateral vocal-cord paralysis; the technique was then modified to allow more tolerance for postoperative nerve edema. A third patient showed asymptomatic vocal-cord paresis on immediate postoperative laryngoscopy. Vagus nerve stimulation produces transient vocal-cord dysfunction while the current is on. Nine patients were randomly assigned to receive either high- or low-current stimulation, and seizure frequency was recorded. The high-current stimulation group showed a median reduction in seizure frequency of 27.7% compared to the preimplantation baseline, while the low-current stimulation group showed a median increase of 6.3%. This difference approached statistical significance. The entire population then received maximally tolerable stimulation. The high-current stimulation group showed a further 14.3% reduction, while the low-current stimulation group showed a 25.4% reduction compared to the blinded period. The efficacy of vagus nerve stimulation seemed to depend on stimulus parameters, and a cumulative effect was evident. These results are encouraging, and further study of this modality as an adjunct treatment for epilepsy is warranted.

Scalp EEG differs in temporal and extratemporal complex partial seizures

1991 ◽  
Vol 4 (1) ◽  
pp. 25-28 ◽  
Author(s):  
Thaddeus S. Walczak ◽  
Darrell V. Lewis ◽  
Rodney Radtke
Keyword(s):  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Scalp Eeg
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