Effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the protective action of various antiepileptic drugs in the maximal electroshock-induced seizure model: a type II isobolographic analysis

Abstract The purpose of this study was to determine the effects of N-(m-bromoanilinomethyl)- p-isopropoxyphenylsuccinimide (BAM-IPPS - a new succinimide derivative) on the protective action of four classical antiepileptic drugs (AEDs: carbamazepine [CBZ], phenobarbital [PB], phenytoin [PHT] and valproate [VPA]) in the mouse maximal electroshock (MES)-induced tonic seizure model. Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (sine-wave, 25 mA, 500 V, 50 Hz, 0.2 s stimulus duration) delivered via ear-clip electrodes. BAM-IPPS administered (i.p.) at a dose of 150 mg/kg significantly elevated the threshold for electroconvulsions in mice (P<0.05). Lower doses of BAM-IPPS (50 and 100 mg/kg) had no significant impact on the threshold for electroconvulsions in mice. Moreover, BAM-IPPS (100 mg/kg) did not significantly affect the anticonvulsant potency of CBZ, PB, PHT and VPA in the mouse MES model. BAM-IPPS elevated the threshold for electroconvulsions in mice in a dosedependent manner. However, BAM-IPPS (100 mg/kg) did not affect the anticonvulsant action of various classical AEDs in the mouse MES model, making the combinations of BAM-IPPS with CBZ, PB, PHT and VPA neutral, from a preclinical point of view.

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Isobolographic analysis of interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and four conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model

European Journal of Pharmacology ◽

10.1016/j.ejphar.2008.11.049 ◽

2009 ◽

Vol 602 (2-3) ◽

pp. 298-305 ◽

Cited By ~ 33

Author(s):

Jarogniew J. Luszczki ◽

Lucyna Antkiewicz-Michaluk ◽

Stanislaw J. Czuczwar

Keyword(s):

Antiepileptic Drugs ◽

Maximal Electroshock ◽

Isobolographic Analysis ◽

Seizure Model

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Isobolographic analysis of interactions between loreclezole and conventional antiepileptic drugs in the mouse maximal electroshock-induced seizure model

Naunyn-Schmiedeberg s Archives of Pharmacology ◽

10.1007/s00210-006-0055-4 ◽

2006 ◽

Vol 373 (2) ◽

pp. 169-181 ◽

Cited By ~ 50

Author(s):

Jarogniew J. Luszczki ◽

Neville Ratnaraj ◽

Philip N. Patsalos ◽

Stanislaw J. Czuczwar

Keyword(s):

Antiepileptic Drugs ◽

Maximal Electroshock ◽

Isobolographic Analysis ◽

Seizure Model

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Pharmacodynamic and Pharmacokinetic Characterization of Interactions between Levetiracetam and Numerous Antiepileptic Drugs in the Mouse Maximal Electroshock Seizure Model: An Isobolographic Analysis

Epilepsia ◽

10.1111/j.1528-1167.2006.00364.x ◽

2006 ◽

Vol 47 (1) ◽

pp. 10-20 ◽

Cited By ~ 43

Author(s):

Jarogniew J. Luszczki ◽

Marta M. Andres ◽

Piotr Czuczwar ◽

Anna Cioczek-Czuczwar ◽

Neville Ratnaraj ◽

...

Keyword(s):

Antiepileptic Drugs ◽

Maximal Electroshock ◽

Maximal Electroshock Seizure ◽

Isobolographic Analysis ◽

Seizure Model

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Interactions of pregabalin with gabapentin, levetiracetam, tiagabine and vigabatrin in the mouse maximal electroshock-induced seizure model: A type II isobolographic analysis

Epilepsy Research ◽

10.1016/j.eplepsyres.2011.09.002 ◽

2012 ◽

Vol 98 (2-3) ◽

pp. 148-156 ◽

Cited By ~ 9

Author(s):

Jarogniew J. Luszczki ◽

Damian Filip ◽

Magdalena Florek-Luszczki

Keyword(s):

Maximal Electroshock ◽

Type Ii ◽

Isobolographic Analysis ◽

Seizure Model

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How Antidepressant Drugs Affect the Antielectroshock Action of Antiseizure Drugs in Mice: A Critical Review

International Journal of Molecular Sciences ◽

10.3390/ijms22052521 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2521

Author(s):

Kinga K. Borowicz-Reutt

Keyword(s):

Antiepileptic Drugs ◽

Neurotrophic Factor ◽

Antidepressant Drugs ◽

Drug Effects ◽

Mechanisms Of Action ◽

Maximal Electroshock ◽

Anticonvulsant Action ◽

Mes Test ◽

Seizure Model ◽

Glial Derived Neurotrophic Factor

Depression coexists with epilepsy, worsening its course. Treatment of the two diseases enables the possibility of interactions between antidepressant and antiepileptic drugs. The aim of this review was to analyze such interactions in one animal seizure model—the maximal electroshock (MES) in mice. Although numerous antidepressants showed an anticonvulsant action, mianserin exhibited a proconvulsant effect against electroconvulsions. In most cases, antidepressants potentiated or remained ineffective in relation to the antielectroshock action of classical antiepileptic drugs. However, mianserin and trazodone reduced the action of valproate, phenytoin, and carbamazepine against the MES test. Antiseizure drug effects were potentiated by all groups of antidepressants independently of their mechanisms of action. Therefore, other factors, including brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) modulation, should be considered as the background for the effect of drug combinations.

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