Characterization of avian influenza viruses isolated from domestic ducks in Vietnam in 2009 and 2010

Abstract Three H10 subtype avian influenza viruses were isolated from domestic ducks in China, designated as SH602/H10N8, FJ1761/H10N3 and SX3180/H10N7, with an intravenous pathogenicity index (IVPI) of 0.39, 1.60, and 1.27, respectively. These H10 viruses showed a complex pathology pattern in different species, although full genome characterizations of the viruses could not identify any molecular determinant underlying the observed phenotypes. Our findings describe the pathobiology of the three H10 subtype AIVs in chickens, ducks, and mice. FJ1761/H10N3 evolved E627K and Q591K substitutions in the gene encoding the PB2 protein in infected mice with severe lung damage, suggesting that H10 subtype avian influenza viruses are a potential threat to mammals.

Download Full-text

Domestic ducks play a major role in the maintenance and spread of H5N8 highly pathogenic avian influenza viruses in South Korea

Transboundary and Emerging Diseases ◽

10.1111/tbed.13406 ◽

2019 ◽

Vol 67 (2) ◽

pp. 844-851 ◽

Cited By ~ 5

Author(s):

Jung‐Hoon Kwon ◽

Justin Bahl ◽

David E. Swayne ◽

Yu‐Na Lee ◽

Youn‐Jeong Lee ◽

...

Keyword(s):

Avian Influenza ◽

South Korea ◽

Highly Pathogenic Avian Influenza ◽

Influenza Viruses ◽

Avian Influenza Viruses ◽

Domestic Ducks ◽

Highly Pathogenic ◽

Pathogenic Avian Influenza

Download Full-text

Ecology of H3 avian influenza viruses in Korea and assessment of their pathogenic potentials

Journal of General Virology ◽

10.1099/vir.0.83462-0 ◽

2008 ◽

Vol 89 (4) ◽

pp. 949-957 ◽

Cited By ~ 34

Author(s):

Min-Suk Song ◽

Taek-Kyu Oh ◽

Ho Jin Moon ◽

Dai-Woon Yoo ◽

Eun Ho Lee ◽

...

Keyword(s):

Avian Influenza ◽

Wild Bird ◽

Migratory Birds ◽

Influenza Viruses ◽

Interspecies Transmission ◽

Avian Influenza Viruses ◽

Backyard Poultry ◽

Live Poultry ◽

Live Poultry Markets

To determine the genetic origins of novel H3 avian influenza viruses of chickens and ducks in Korea, genetic characterization of H3 avian influenza viruses isolated from live poultry markets and migratory aquatic birds in South Korea during 2004–2006 was conducted. Phylogenetic analysis revealed that at least four novel genotypes of H3N2 and two genotypes of H3N6 avian influenza viruses were co-circulating in backyard poultry of Korea. The viruses were reassortants between H9N2 viruses of Korean chickens and unknown influenza viruses of migratory birds. Genetic comparison of H3 viruses from live bird markets with those from wild bird isolates revealed that certain gene segments of wild bird isolates are related closely to those of Korean group H9N2 viruses isolated from live poultry markets in 2003. Furthermore, animal-challenge studies demonstrated that the pathogenicity of certain avian H3 influenza viruses was altered due to reassortment, leading to H3 avian influenza viruses in Korea that can potentially expand their host range to include mammals. These studies emphasize the continuing need to monitor backyard poultry at live poultry markets to better understand interspecies transmission and the emergence of novel influenza viruses that have the potential to infect humans.

Download Full-text